{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:31:46Z","timestamp":1784241106488,"version":"3.55.0"},"reference-count":17,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008593","name":"European Respiratory Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>There is a lack of data evaluating the clinical effect on symptoms of pleural intervention procedures. This has led to the development of patient-reported outcome measures (PROMs) to define what constitutes patient benefit. The primary aim of this paper was to prospectively assess the effect of pleural procedures on PROMs and investigate the relationship between symptom change and clinical factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We prospectively collected data as part of routine clinical care from 158 patients with pleural effusion requiring interventions. Specific questionnaires included two patient-reported scores (a seven-point Likert scale and a 100\u2009mm visual analogue scale (VAS) to assess symptoms).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Excluding diagnostic aspiration, the majority of patients (108\/126, 85.7%) experienced symptomatic benefit from fluid drainage (mean VAS improvement 42.6\u2009mm, SD 24.7, 95%\u2009CI 37.9 to 47.3). There was a correlation between symptomatic benefit and volume of fluid removed post aspiration. A negative association was identified between the number of septations seen on ultrasound and improvement in dyspnoea VAS score in patients treated with intercostal chest drain.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The results of our study highlight the effect of pleural interventions from a patient\u2019s perspective. The outcomes defined have the potential to form the basis of a clinical useful tool to appraise the effect, compare the efficiency and identify the importance of pleural interventions to the patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjresp-2016-000171","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T20:10:20Z","timestamp":1499112620000},"page":"e000171","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":37,"title":["Assessment of patient-reported outcome measures in pleural interventions"],"prefix":"10.1136","volume":"4","author":[{"given":"Ioannis","family":"Psallidas","sequence":"first","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Yousuf","sequence":"additional","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambika","family":"Talwar","sequence":"additional","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob J","family":"Hallifax","sequence":"additional","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleanor K","family":"Mishra","sequence":"additional","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P","family":"Corcoran","sequence":"additional","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nabeel","family":"Ali","sequence":"additional","affiliation":[{"name":"Respiratory Department, King\u2019s Mill Hospital, Mansfield, Nottinghamshire, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Najib M","family":"Rahman","sequence":"additional","affiliation":[{"name":"Oxford Centre for Respiratory Medicine and Oxford Respiratory Trials Unit, Oxford University Hospitals NHS Foundation Trust, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,7,3]]},"reference":[{"key":"2025083111181288000_4.1.e000171.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.disamonth.2012.11.002"},{"key":"2025083111181288000_4.1.e000171.2","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136978"},{"key":"2025083111181288000_4.1.e000171.3","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.156406"},{"key":"2025083111181288000_4.1.e000171.4","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1183\/09031936.93.02040366","article-title":"Pleural metastatic tumours and effusions. frequency and pathogenic mechanisms in a post-mortem series","volume":"2","author":"Rodr\u00eeguez-Panadero","year":"1989","journal-title":"Eur Respir J"},{"key":"2025083111181288000_4.1.e000171.5","unstructured":"Health and Safety Executive. Mesothelioma in Great Britain 2014: health and safety executive, 2014."},{"key":"2025083111181288000_4.1.e000171.6","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206577"},{"key":"2025083111181288000_4.1.e000171.7","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0020-2016"},{"key":"2025083111181288000_4.1.e000171.8","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.5535"},{"key":"2025083111181288000_4.1.e000171.9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.137026"},{"key":"2025083111181288000_4.1.e000171.10","unstructured":"Guidance on the routine collection of Patient Reported Outcome measures (PROMs) for the NHS in England. London, UK: BMJ Publishing Group, 2010."},{"key":"2025083111181288000_4.1.e000171.11","doi-asserted-by":"crossref","first-page":"e0123798","DOI":"10.1371\/journal.pone.0123798","article-title":"Defining the minimal important difference for the visual analogue scale assessing dyspnea in patients with malignant pleural effusions","volume":"10","author":"Mishra","year":"2015","journal-title":"PLoS One"},{"key":"2025083111181288000_4.1.e000171.12","doi-asserted-by":"publisher","DOI":"10.1177\/0269216314521851"},{"key":"2025083111181288000_4.1.e000171.13","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1868"},{"key":"2025083111181288000_4.1.e000171.14","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<1992::AID-CNCR16>3.0.CO;2-M"},{"key":"2025083111181288000_4.1.e000171.15","doi-asserted-by":"publisher","DOI":"10.1042\/cs0760277"},{"key":"2025083111181288000_4.1.e000171.16","first-page":"5131","article-title":"Improved quality of life in patients with malignant pleural effusion following videoassisted thoracoscopic talc pleurodesis. preliminary results","volume":"32","author":"Basso","year":"2012","journal-title":"Anticancer Res"},{"key":"2025083111181288000_4.1.e000171.17","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2014-206658"}],"container-title":["BMJ Open Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjresp-2016-000171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T18:18:25Z","timestamp":1756664305000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopenrespres.bmj.com\/lookup\/doi\/10.1136\/bmjresp-2016-000171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,7,3]]},"published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1136\/bmjresp-2016-000171"],"URL":"https:\/\/doi.org\/10.1136\/bmjresp-2016-000171","relation":{},"ISSN":["2052-4439"],"issn-type":[{"value":"2052-4439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7]]}}}