{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:25:26Z","timestamp":1789993526766,"version":"4.0.1"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2017,1,4]]},"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Early rehabilitation has become widespread practice for patients in intensive care; however, the prevalence of intensive care unit-acquired weakness remains high and the majority of physiotherapy is carried out in bed. Several inbed rehabilitation methods exist, but we hypothesise that techniques that provoke muscle contractions are more effective than passive techniques.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A randomised, controlled cross-over study will be carried out to evaluate and compare the effectiveness of early rehabilitation techniques on cardiac output (CO) in sedated patients in intensive care. 20 intubated and sedated patients will undergo 4 10 min rehabilitation sessions. 2 sessions will involve \u2018passive\u2019 techniques based on mobilisations and inbed cycle ergometry and 2 involving electrostimulation of the quadriceps muscle and Functional Electrical Stimulation-cycling (FES-cycling). The primary outcome is CO measured by Doppler ultrasound. The secondary outcomes are right ventricular function, pulmonary systolic arterial pressure, muscle oxygenation and minute ventilation during exercise.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results and conclusion<\/jats:title>\n                  <jats:p>Approval has been granted by our Institutional Review Board (Comit\u00e9 de Protection des Personnes Nord-Ouest 3). The results of the trial will be presented at national and international meetings and published in peer-reviewed journals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>NCT02920684.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjresp-2016-000173","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T21:20:30Z","timestamp":1485811230000},"page":"e000173","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Effects of different early rehabilitation techniques on haemodynamic and metabolic parameters in sedated patients: protocol for a randomised, single-bind, cross-over trial"],"prefix":"10.1136","volume":"4","clinical-trial-number":[{"clinical-trial-number":"nct02920684","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Cl\u00e9ment","family":"Medrinal","sequence":"first","affiliation":[{"name":"Normandie Univ, UNIROUEN, EA3830\u2014GRHV, Rouen, France"},{"name":"Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France"},{"name":"Intensive Care Unit Department, Groupe Hospitalier du Havre, Montivilliers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"Combret","sequence":"additional","affiliation":[{"name":"Physiotherapy Department, Groupe Hospitalier du Havre, Montivilliers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Prieur","sequence":"additional","affiliation":[{"name":"Pulmonology Department, Groupe Hospitalier du Havre, Montivilliers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Robledo Quesada","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Department, Groupe Hospitalier du Havre, Montivilliers, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tristan","family":"Bonnevie","sequence":"additional","affiliation":[{"name":"ADIR Association, Bois Guillaume, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Edouard","family":"Gravier","sequence":"additional","affiliation":[{"name":"ADIR Association, Bois Guillaume, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9ric","family":"Frenoy","sequence":"additional","affiliation":[{"name":"Intensive Care Unit Department, Groupe Hospitalier du Havre, Le Havre, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Contal","sequence":"additional","affiliation":[{"name":"University of Applied Sciences and Arts Western Switzerland (HES-SO), Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouchra","family":"Lamia","sequence":"additional","affiliation":[{"name":"Normandie Univ, UNIROUEN, EA3830\u2014GRHV, Rouen, France"},{"name":"Institute for Research and Innovation in Biomedicine (IRIB), Rouen, France"},{"name":"Pulmonology Department, Groupe Hospitalier du Havre, Montivilliers, France"},{"name":"Intensive Care Unit, Respiratory Department, Rouen University Hospital, Rouen, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"2025083109352749000_4.1.e000173.1","doi-asserted-by":"crossref","unstructured":"Tipping CJ , Harrold M , Holland A , et al . The effects of active mobilization and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med 2016. 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