{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T13:19:46Z","timestamp":1790601586676,"version":"4.1.0"},"reference-count":42,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2021,7,26]]},"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Massive haemoptysis is a life-threatening event in advanced cystic fibrosis (CF) lung disease with bronchial artery embolisation (BAE) as standard of care treatment. The aim of our study was to scrutinise short-term and long-term outcomes of patients with CF and haemoptysis after BAE using coils.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We carried out a retrospective cohort study of 34 adult patients treated for massive haemoptysis with super selective bronchial artery coil embolisation (ssBACE) between January 2008 and February 2015. Embolisation protocol was restricted to the culprit vessel(s) and three lobes maximum. Demographic data, functional end-expiratory volume in 1\u2009s in % predicted (FEV1% pred.) and body mass index before and after ssBACE, sputum colonisation, procedural data, time to transplant and time to death were documented.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients treated with ssBACE showed significant improvement of FEV<jats:sub>1<\/jats:sub>% pred. after embolisation (p=0.004) with 72.8% alive 5\u2009years post-ssBACE. Mean age of the patients was 29.9 years (\u00b17.7). Mean FEV<jats:sub>1<\/jats:sub>% pred. was 45.7% (\u00b120.1). Median survival to follow-up was 75 months (0\u2013125). Severe complication rate was 0%, recanalisation rate 8.8% and 5-year-reintervention rate 58.8%. Chronic infection with <jats:italic>Pseudomonas aeruginosa<\/jats:italic> was found in 79.4%, <jats:italic>Staphylococcus areus<\/jats:italic> in 50% and <jats:italic>Aspergillus fumigatus<\/jats:italic> in 47.1%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Discussion<\/jats:title>\n                  <jats:p>ssBACE is a safe and effective treatment for massive haemoptysis in patients with CF with good results for controlling haemostasis and excellent short-term and long-term survival, especially in severely affected patients with FEV&lt;40% pred. We think the data of our study support the use of coils and a protocol of careful and prudent embolisation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjresp-2021-000985","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T12:25:01Z","timestamp":1628771101000},"page":"e000985","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Coil embolisation for massive haemoptysis in cystic fibrosis"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2471-8530","authenticated-orcid":false,"given":"Martha","family":"Dohna","sequence":"first","affiliation":[{"name":"Pediatric Radiology, Hannover Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane Miriam","family":"Renz","sequence":"additional","affiliation":[{"name":"Radiology, Hannover Medical School, Hannover, 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