{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T17:10:04Z","timestamp":1756660204033,"version":"3.44.0"},"reference-count":29,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,5,16]],"date-time":"2022-05-16T00:00:00Z","timestamp":1652659200000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Waikato Hospital Respiratory Research Unit Open Access Grant"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2022,5,5]]},"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Non-invasive ventilation (NIV), although effective in treating hypercapnic respiratory failure, has not demonstrated the same efficacy in treating acute hypoxaemic respiratory failure. We aimed to examine the effect of NIV use on ventilator-free days in patients with acute hypoxaemic respiratory failure admitted to the intensive care unit (ICU).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a retrospective study of patients admitted to the ICU with acute hypoxaemic respiratory failure at Waikato Hospital, New Zealand, from 1 January 2009 to 31 December 2018. Patients treated with NIV as the initial oxygenation strategy were compared with controls treated with early intubation. The two groups were matched using a propensity score based on baseline characteristics. The primary outcome was the number of ventilator-free days at day 28. The secondary outcomes were ICU and hospital length of stay and in-hospital mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 175 eligible patients, 79 each out of the NIV and early intubation groups were matched using a propensity score. Early NIV was associated with significantly higher median ventilator-free days than early intubation (17 days vs 23 days, p=0.013). There was no significant difference in median ICU length of stay (112.5 hours vs 117.7 hours), hospital length of stay (14 days vs 14 days) or in-hospital mortality (31.6% vs 37.9%) between the NIV and the early intubation group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Compared with early intubation, NIV use was associated with more ventilator-free days in patients with hypoxaemic respiratory failure. However, this did not translate into a shorter length of stay or reduced mortality based on our single-centre experience.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjresp-2021-001149","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T13:39:22Z","timestamp":1653313162000},"page":"e001149","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Non-invasive ventilation for acute hypoxaemic respiratory failure: a propensity-matched cohort study"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8322-9227","authenticated-orcid":false,"given":"Dilip","family":"Jayasimhan","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine and Respiratory Research Unit, Waikato Hospital, Hamilton, New Zealand"},{"name":"Intensive Care Unit, Waikato Hospital, Hamilton, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert Adam","family":"Martynoga","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, Waikato Hospital, Hamilton, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah M","family":"Fairweather","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Respiratory Research Unit, Waikato Hospital, Hamilton, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherina L","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Respiratory Research Unit, Waikato Hospital, Hamilton, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"key":"2025083109330013000_9.1.e001149.1","doi-asserted-by":"crossref","DOI":"10.1186\/s13613-018-0424-4","article-title":"Hypoxemia in the ICU: prevalence, treatment, and outcome","volume":"8","author":"","year":"2018","journal-title":"Ann Intensive Care"},{"key":"2025083109330013000_9.1.e001149.2","unstructured":"Pham T , Pesenti A , Bellani G . Outcome of acute Hypoxaemic respiratory failure. insights from the lung safe study. Eur Respir J 2020. [Epub ahead of print: Available from] https:\/\/erj.ersjournals.com\/content\/early\/2020\/11\/26\/13993003.03317-2020"},{"key":"2025083109330013000_9.1.e001149.3","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000002361"},{"key":"2025083109330013000_9.1.e001149.4","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02426-2016","article-title":"Official ERS\/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure","volume":"50","author":"Rochwerg","year":"2017","journal-title":"Eur Respir J"},{"key":"2025083109330013000_9.1.e001149.5","doi-asserted-by":"crossref","unstructured":"Osadnik CR , Tee VS , Carson-Chahhoud KV , et al . Non\u2010invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease. 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