{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:47:54Z","timestamp":1785401274156,"version":"3.56.0"},"reference-count":54,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001869","name":"Academia Sinica","doi-asserted-by":"publisher","award":["109-01-2"],"award-info":[{"award-number":["109-01-2"]}],"id":[{"id":"10.13039\/501100001869","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2022,11,22]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                  <jats:title>Background and objective<\/jats:title>\n                  <jats:p>Obesity and asthma impose a heavy health and economic burden on millions of people around the world. The complex interaction between genetic traits and phenotypes caused the mechanism between obesity and asthma is still vague. This study investigates the relationship among obesity-related polygenic risk score (PRS), obesity phenotypes and the risk of having asthma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a matched case\u2013control study, with 4 controls (8288 non-asthmatic) for each case (2072 asthmatic). Data were obtained from the 2008\u20132015 Taiwan Biobank Database and linked to the 2000\u20132016 National Health Insurance Research Database. All participants were \u226530 years old with no history of cancer and had a complete questionnaire, as well as physical examination, genome-wide single nucleotide polymorphisms and clinical diagnosis data. Environmental exposure, PM<jats:sub>2.5<\/jats:sub>, was also considered. Multivariate adjusted ORs and 95% CIs were calculated using conditional logistic regression stratified by age and sex. Mediation analysis was also assessed, using a generalised linear model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found that the obese phenotype was associated with significantly increased odds of asthma by approximately 26%. Four obesity-related PRS, including body mass index (OR=1.07 (1.01\u20131.13)), waist circumference (OR=1.10 (1.04\u20131.17)), central obesity as defined by waist-to-height ratio (OR=1.09 (1.03\u20131.15)) and general\u2013central obesity (OR=1.06 (1.00\u20131.12)), were associated with increased odds of asthma. Additional independent risk factors for asthma included lower educational level, family history of asthma, certain chronic diseases and increased PM<jats:sub>2.5<\/jats:sub> exposure. Obesity-related PRS is an indirect risk factor for asthma, the link being fully mediated by the trait of obesity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Obese phenotypes and obesity-related PRS are independent risk factors for having asthma in adults in the Taiwan Biobank. Overall, genetic risk for obesity increases the risk of asthma by affecting the obese phenotype.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjresp-2022-001355","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T09:37:52Z","timestamp":1670319472000},"page":"e001355","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Relationship among genetic variants, obesity traits and asthma in the Taiwan Biobank"],"prefix":"10.1136","volume":"9","author":[{"given":"Ying-Jhen","family":"Huang","sequence":"first","affiliation":[{"name":"Research Center for Humanities and Social Sciences, Academia Sinica, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Chi","family":"Chu","sequence":"additional","affiliation":[{"name":"Research Center for Humanities and Social Sciences, Academia Sinica, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Statistical Science, Academia Sinica, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsin-Chou","family":"Yang","sequence":"additional","affiliation":[{"name":"Institute of Statistical Science, Academia Sinica, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Ling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung City, Taiwan"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan"},{"name":"Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Shiang","family":"Hwang","sequence":"additional","affiliation":[{"name":"Institute of Statistical Science, Academia Sinica, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Houh","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Statistical Science, Academia Sinica, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-783X","authenticated-orcid":false,"given":"Ta-Chien","family":"Chan","sequence":"additional","affiliation":[{"name":"Research Center for Humanities and Social Sciences, Academia Sinica, Taipei City, Taiwan"},{"name":"Institute of Public Health, School of Medicine, National Yang Ming Chiao Tung University, Taipei City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"2025083112240086000_9.1.e001355.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"2025083112240086000_9.1.e001355.2","unstructured":"World Health Organization (WHO) . 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