{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T13:34:33Z","timestamp":1767792873377,"version":"3.49.0"},"reference-count":34,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Chief Scientist Office of the Scottish Government","award":["COV\/GLA\/311300"],"award-info":[{"award-number":["COV\/GLA\/311300"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2024,12,22]]},"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The radiological trajectory of post-COVID-19 is uncertain. We present a prospective, observational, multicentre cohort study using multimodality imaging to describe the pulmonary sequelae of patients hospitalised with COVID-19, predictors of persistent abnormal radiology and implications on health status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In survivors of COVID-19, we performed convalescent CT pulmonary angiogram and high-resolution CT imaging as part of the CISCO-19 study (ClinicalTrials.gov ID\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04403607\">NCT04403607<\/jats:ext-link>\n                      ). This included serial blood biomarkers and patient-reported outcomes 28\u201360\u2009days following discharge from hospital.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of the COVID-19 cohort, 88 (56%) patients of the COVID-19 cohort (n\u2009=\u2009159; mean age, 55 years; 43% female) had persisting radiological abnormalities at 28\u201360\u2009days postdischarge. This included ground-glass opacification (45%), reticulation\/architectural distortion (30%) or mixed pattern (19%). These features were very infrequent among a group of age-matched, sex-matched and cardiovascular risk factor-matched controls (n=29). The majority of COVID-19 cohort (68%) had less than 20% persisting radiological abnormalities, with 67% demonstrating overall improvement compared with admission imaging. Older age, premorbid performance status, typical acute COVID-19 radiological features, markers of severe acute COVID-19, convalescent ICAM-1 and P-selectin were associated with persisting lung abnormalities (all p&lt;0.05). Patients with persisting abnormalities were shown to have lower levels of physical activity and predicted maximal oxygen utilisation (derived VO\n                      <jats:sub>2<\/jats:sub>\n                      ) (both p&lt;0.05). Higher percentage of abnormal lung parenchyma was associated with lower patient-assessed quality of life (EQ-5D-5L) score (p=0.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Persistent radiological abnormalities post-COVID-19 were common at 28\u201360\u2009days postdischarge from hospital, although most improved. Patients with persisting radiological abnormalities 28\u201360\u2009days postdischarge are at risk of persisting health impairment in the longer term and represent a population for targeted intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04403607\">NCT04403607<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjresp-2023-001985","type":"journal-article","created":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T11:55:40Z","timestamp":1739188540000},"page":"e001985","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Radiological abnormalities persist following COVID-19 and correlate with impaired health-related quality of life: a prospective cohort study of hospitalised patients"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct04403607","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04403607","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"isrctn10980107","registry":"10.18810\/isrctn"},{"clinical-trial-number":"nct04403607","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Robert","family":"Sykes","sequence":"first","affiliation":[{"name":"University of Glasgow, Glasgow, UK"},{"name":"Regional Heart and Lung Centre, Golden Jubilee Hospital, Clydebank, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew J","family":"Morrow","sequence":"additional","affiliation":[{"name":"University of Glasgow, Glasgow, UK"},{"name":"Regional Heart and Lung Centre, Golden Jubilee Hospital, Clydebank, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Mangion","sequence":"additional","affiliation":[{"name":"University of Glasgow, Glasgow, UK"},{"name":"Department of Cardiology, Queen Elizabeth University Hospital, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"McConnachie","sequence":"additional","affiliation":[{"name":"Robertson Centre for Biostatistics, School of Health and Wellbeing, University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alasdair","family":"McIntosh","sequence":"additional","affiliation":[{"name":"University of Glasgow, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giles","family":"Roditi","sequence":"additional","affiliation":[{"name":"Radiology, Glasgow Royal Infirmary, Glasgow, 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