{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T08:09:58Z","timestamp":1794038998543,"version":"4.8.0"},"reference-count":79,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001247","name":"Thoracic Society of Australia and New Zealand","doi-asserted-by":"crossref","award":["Robert Pierce Grant-In-Aid for Indigenous Lung Hea"],"award-info":[{"award-number":["Robert Pierce Grant-In-Aid for Indigenous Lung Hea"]}],"id":[{"id":"10.13039\/501100001247","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2024,12,22]]},"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Globally, adult Indigenous people, including Aboriginal Australians, have a high burden of chronic respiratory disorders, and bronchiectasis is no exception. However, literature detailing bronchiectasis disease characteristics among adult Indigenous people is sparse. This study assessed the clinical profile of bronchiectasis among adult Aboriginal Australians and compared against previously published international bronchiectasis registry reports.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Aboriginal Australians aged &gt;18 years with chest CT confirmed bronchiectasis between 2011 and 2020 in the Top End Northern Territory of Australia were included. Demographics, chest CT findings, pulmonary function results, sputum microbiology, coexistent medical comorbidities, and pharmacotherapy use were assessed and compared against five published international bronchiectasis registry reports (Australian (ABR), European (European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC)-Europe), Indian (EMBARC-India), Korean (KMBARC) and the USA (USBRR)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 459 patients were assessed. In comparison with international and non-Aboriginal Australian national cohorts, Aboriginal Australians were younger (median 56 years (IQR (48, 65)); however, sex distribution (55% female) and body mass index (23 kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      (IQR 19.4\u201327)) were comparable . Smoking rates were higher at 85% compared with other registry cohorts (22\u201346%) as was the prevalence of comorbidities (97%): cardiovascular diseases (73%), diabetes mellitus (50%) and chronic obstructive pulmonary disease (83%) compared with other registry cohorts (4\u201332%; 6\u201314%; and 14\u201337%, respectively). Spirometry demonstrated forced expiratory volume in 1\u2009s of 38% predicted in comparison with 61\u201377% in other cohorts. Sputum microbiology showed\n                      <jats:italic>Haemophilus influenzae<\/jats:italic>\n                      (57%) isolated at 3.4 to 6 times the rate of other registry cohorts and\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                      in 31%. Chest CT demonstrated multilobar and lower lobes involvement in 73% and inhaled pharmacotherapy use was recorded in up to 62% and long-term antibiotics in 5%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The overall bronchiectasis disease burden is higher in Aboriginal Australian adults in comparison with global ethnically diverse non-Indigenous populations. Further efforts are required to address this disparity secondary to bronchiectasis among Indigenous people.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjresp-2023-002139","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T23:15:42Z","timestamp":1737501342000},"page":"e002139","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Retrospective cross-sectional study on bronchiectasis in adult Aboriginal Australians: disease characteristics and comparison with ethnically diverse global bronchiectasis registry cohorts"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0788-7137","authenticated-orcid":false,"given":"Subash","family":"Heraganahally","sequence":"first","affiliation":[{"name":"Department of Respiratory and Sleep Medicine, Royal Darwin Hospital, Darwin, Northern Territory, Australia"},{"name":"Northern Territory Medical 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