{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T09:20:16Z","timestamp":1784712016858,"version":"3.55.0"},"reference-count":41,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T00:00:00Z","timestamp":1722988800000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Beijing Hospitals Authority Clinical medicine Development","award":["ZLRK202306"],"award-info":[{"award-number":["ZLRK202306"]}]},{"name":"Beijing Hospitals Authority\u2019s Ascent Plan","award":["DFL20220303"],"award-info":[{"award-number":["DFL20220303"]}]},{"name":"Beijing Key Specialists in Major Epidemic Prevention and Control"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2024,7,8]]},"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>This meta-analysis aims to evaluate the agreement and correlation between phase-resolved functional lung MRI (PREFUL MRI) and dynamic contrast-enhanced (DCE) MRI in evaluating perfusion defect percentage (QDP), as well as the agreement between PREFUL MRI and <jats:sup>129<\/jats:sup>Xe MRI in assessing ventilation defect percentage (VDP).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>A systematic search was conducted in the Medline, Embase and Cochrane Library databases to identify relevant studies comparing QDP and VDP measured by DCE MRI and <jats:sup>129<\/jats:sup>Xe MRI compared with PREFUL MRI. Meta-analytical techniques were applied to calculate the pooled weighted bias, limits of agreement (LOA) and correlation coefficient. The publication bias was assessed using Egger\u2019s regression test, while heterogeneity was assessed using Cochran\u2019s Q test and Higgins I<jats:sup>2<\/jats:sup> statistic.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 399 subjects from 10 studies were enrolled. The mean difference and LOA were \u22122.31% (\u22128.01% to 3.40%) for QDP and 0.34% (\u22124.94% to 5.62%) for VDP. The pooled correlations (95% CI) were 0.65 (0.55 to 0.73) for QDP and 0.72 (0.61 to 0.80) for VDP. Furthermore, both QDP and VDP showed a negative correlation with forced expiratory volume in 1 s (FEV<jats:sub>1<\/jats:sub>). The pooled correlation between QDP and FEV<jats:sub>1<\/jats:sub> was \u22120.51 (\u22120.74 to \u22120.18), as well as between VDP and FEV<jats:sub>1<\/jats:sub> was \u22120.60 (\u22120.73 to \u22120.44).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>PREFUL MRI is a promising imaging for the assessment of lung function, as it demonstrates satisfactory deviations and LOA when compared with DEC MRI and <jats:sup>129<\/jats:sup>Xe MRI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration number<\/jats:title>\n                  <jats:p>CRD42023430847.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjresp-2023-002198","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T03:48:20Z","timestamp":1723088900000},"page":"e002198","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Phase-resolved MRI for measurement of pulmonary perfusion and ventilation defects in comparison with dynamic contrast-enhanced MRI and <sup>129<\/sup>Xe MRI"],"prefix":"10.1136","volume":"11","author":[{"given":"Tao","family":"Ouyang","sequence":"first","affiliation":[{"name":"Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"},{"name":"Key Laboratory of Medical Engineering for Cardiovascular Disease, Ministry of Education, Beijing, China"},{"name":"Laboratory for Clinical Medicine, Capital Medical University, Beijing, 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