{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:59:03Z","timestamp":1768323543875,"version":"3.49.0"},"reference-count":45,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T00:00:00Z","timestamp":1733270400000},"content-version":"unspecified","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Guangzhou Lab Research Project","award":["SRPG22-017"],"award-info":[{"award-number":["SRPG22-017"]}]},{"name":"National Key Research & Development Programme","award":["2022YFC2505100"],"award-info":[{"award-number":["2022YFC2505100"]}]},{"name":"Science and Technology Planning Project of Guangzhou","award":["202206080013"],"award-info":[{"award-number":["202206080013"]}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["82022048"],"award-info":[{"award-number":["82022048"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["82373121"],"award-info":[{"award-number":["82373121"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2024,10,24]]},"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aims to explore how pre-existing conditions such as blood types, family history of cancer and comorbid diseases correlate with the genetic and programmed death-ligand 1 (PD-L1) expression that contributes to the heterogeneous biological behaviours of non-small cell lung cancer (NSCLC).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>A cohort of 5507 NSCLC patients who underwent surgical resection between January 2014 and July 2018 was studied. Targeted next-generation sequencing was used to detect mutations in nine pivotal cancer-related genes, and immunohistochemical staining was applied to assess PD-L1 expression. Logistic regression analysis was employed to identify significant correlations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>All patients underwent NGS, with 1839 were also evaluated for PD-L1 expression. Several significant findings were found: ROS1 mutations were closely associated with a family history of lung cancer (OR 7.499, 95% CI 1.094 to 30.940, p=0.013). Epidermal growth factor receptor (EGFR) L858R mutations were common among patients with a family history of non-lung cancers and those with hypertension (OR 2.089, 95% CI 1.029 to 4.135, p=0.037\u2009and OR 1.252, 95% CI 1.001 to 1.562, p=0.048, respectively). Pre-existing conditions such as diabetes and hepatitis B surface antigen positivity (OR 1.468, 95% CI 1.042 to 2.047, p=0.026\u2009and OR 1.373, 95% CI 1.012 to 1.847, p=0.038, respectively) were correlated with EGFR exon 19 deletions. RhD negativity showed potential ties to BRAF mutations (OR 0.010, 95% CI 0.001 to 0.252, p=0.001). A history of tuberculosis linked to increased PD-L1 expression in immune cells (OR 3.597, 95% CI 1.295 to 14.957, p=0.034).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This large-scale, cross-sectional study reveals a complex interplay between genetic mutations, immunological features and pre-existing conditions in NSCLC patients, offering insights that could inform personalised treatment strategies.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjresp-2024-002571","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T21:15:16Z","timestamp":1733346916000},"page":"e002571","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association of pre-existing conditions with major driver mutations and PD-L1 expression in NSCLC"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0636-3032","authenticated-orcid":false,"given":"Peiling","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caichen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianfu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Mathematical Sciences, University of Southampton, Southampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1155-5963","authenticated-orcid":false,"given":"Hengrui","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhichao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Shanghai Institute of Thoracic Oncology, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuting","family":"Zhan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhai","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjun","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo\u2019ao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianzhe","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-8192","authenticated-orcid":false,"given":"Jianxing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1391-8238","authenticated-orcid":false,"given":"Wenhua","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery and Oncology, the First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease & National Clinical Research Center for Respiratory Disease, Guangzhou, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,12,4]]},"reference":[{"key":"2025083111041773000_11.1.e002571.1","doi-asserted-by":"publisher","DOI":"10.1200\/Jco.21.01497"},{"key":"2025083111041773000_11.1.e002571.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01626"},{"key":"2025083111041773000_11.1.e002571.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa040938"},{"key":"2025083111041773000_11.1.e002571.4","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature05945","article-title":"Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer","volume":"448","author":"Soda","year":"2007","journal-title":"Nature New Biol"},{"key":"2025083111041773000_11.1.e002571.5","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.35.6345"},{"key":"2025083111041773000_11.1.e002571.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1913662"},{"key":"2025083111041773000_11.1.e002571.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2027187"},{"key":"2025083111041773000_11.1.e002571.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30690-4"},{"key":"2025083111041773000_11.1.e002571.9","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30146-2"},{"key":"2025083111041773000_11.1.e002571.10","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa2103695"},{"key":"2025083111041773000_11.1.e002571.11","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2644"},{"key":"2025083111041773000_11.1.e002571.12","article-title":"A genomics-based classification of human lung tumors","volume":"5","year":"2013","journal-title":"Sci Transl Med"},{"key":"2025083111041773000_11.1.e002571.13","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01721-2016","article-title":"Comorbidities in the management of patients with lung cancer","volume":"49","author":"Leduc","year":"2017","journal-title":"Eur Respir J"},{"key":"2025083111041773000_11.1.e002571.14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0142306","article-title":"Chronic Obstructive Pulmonary Disease-Related Non-Small-Cell Lung Cancer Exhibits a Low Prevalence of EGFR and ALK Driver Mutations","volume":"10","author":"Lim","year":"2015","journal-title":"PLoS One"},{"key":"2025083111041773000_11.1.e002571.15","doi-asserted-by":"crossref","first-page":"765","DOI":"10.21873\/anticanres.11375","article-title":"Frequency of Epidermal Growth Factor Receptor Mutation in Smokers with Lung Cancer Without Pulmonary Emphysema","volume":"37","author":"Takeda","year":"2017","journal-title":"Anticancer Res"},{"key":"2025083111041773000_11.1.e002571.16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.lungcan.2013.01.017","article-title":"Preexisting interstitial lung disease is inversely correlated to tumor epidermal growth factor receptor mutation in patients with lung adenocarcinoma","volume":"80","author":"Fujimoto","year":"2013","journal-title":"Lung Cancer (Auckl)"},{"key":"2025083111041773000_11.1.e002571.17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152317","article-title":"Chronic Obstructive Pulmonary Disease Is Not Associated with KRAS Mutations in Non-Small Cell Lung Cancer","volume":"11","author":"Saber","year":"2016","journal-title":"PLoS One"},{"key":"2025083111041773000_11.1.e002571.18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.lungcan.2015.01.004","article-title":"Expression of insulin-like growth factor 1 receptor (IGF-1R) predicts poor responses to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors in non-small cell lung cancer patients harboring activating EGFR mutations","volume":"87","author":"Yeo","year":"2015","journal-title":"Lung Cancer (Auckl)"},{"key":"2025083111041773000_11.1.e002571.19","doi-asserted-by":"crossref","first-page":"5285","DOI":"10.7314\/APJCP.2015.16.13.5285","article-title":"Hepatitis B Virus Infection Is Associated with Poor Prognosis in Patients with Advanced Non Small Cell Lung Cancer","volume":"16","author":"Peng","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"2025083111041773000_11.1.e002571.20","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S1995-7645(14)60326-6","article-title":"Relevance of EGFR gene mutation with pathological features and prognosis in patients with non-small-cell lung carcinoma","volume":"8","author":"Wang","year":"2015","journal-title":"Asian Pac J Trop Med"},{"key":"2025083111041773000_11.1.e002571.21","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.lungcan.2013.05.004","article-title":"Impact of family history of cancer on the incidence of mutation in epidermal growth factor receptor gene in non-small cell lung cancer patients","volume":"81","author":"He","year":"2013","journal-title":"Lung Cancer (Auckl)"},{"key":"2025083111041773000_11.1.e002571.22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.lungcan.2012.12.002","article-title":"Family history of lung cancer in never smokers with non-small-cell lung cancer and its association with tumors harboring EGFR mutations","volume":"79","author":"Gaughan","year":"2013","journal-title":"Lung Cancer (Auckl)"},{"key":"2025083111041773000_11.1.e002571.23","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30406-5"},{"key":"2025083111041773000_11.1.e002571.24","doi-asserted-by":"crossref","DOI":"10.1186\/s13045-017-0479-y","article-title":"Clinical applications of PD-L1 bioassays for cancer immunotherapy","volume":"10","author":"Liu","year":"2017","journal-title":"J Hematol Oncol"},{"key":"2025083111041773000_11.1.e002571.25","doi-asserted-by":"crossref","first-page":"22338","DOI":"10.1038\/srep22338","article-title":"A targeted next-generation sequencing method for identifying clinically relevant mutation profiles in lung adenocarcinoma","volume":"6","author":"Shao","year":"2016","journal-title":"Sci Rep"},{"key":"2025083111041773000_11.1.e002571.26","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000481"},{"key":"2025083111041773000_11.1.e002571.27","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-11-3265"},{"key":"2025083111041773000_11.1.e002571.28","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1001\/jamaoncol.2015.4482","article-title":"Association Between Younger Age and Targetable Genomic Alterations and Prognosis in Non-Small-Cell Lung Cancer","volume":"2","author":"Sacher","year":"2016","journal-title":"JAMA Oncol"},{"key":"2025083111041773000_11.1.e002571.29","doi-asserted-by":"crossref","unstructured":"Cai L , Chen Y , Tong X , et al . The genomic landscape of young and old lung cancer patients highlights age-dependent mutation frequencies and clinical actionability in young patients. Int J Cancer 2021;2. doi:10.1002\/ijc.33583","DOI":"10.1002\/ijc.33583"},{"key":"2025083111041773000_11.1.e002571.30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/1759-7714.12899","article-title":"Prevalence of ROS1 fusion in Chinese patients with non\u2010small cell lung cancer","volume":"10","author":"Zhang","year":"2019","journal-title":"Thorac Cancer"},{"key":"2025083111041773000_11.1.e002571.31","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt071"},{"key":"2025083111041773000_11.1.e002571.32","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-019-6317-6","article-title":"Potential genetic modifiers for somatic EGFR mutation in lung cancer: a meta-analysis and literature review","volume":"19","author":"Cheng","year":"2019","journal-title":"BMC Cancer"},{"key":"2025083111041773000_11.1.e002571.33","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.jtho.2018.12.006","article-title":"EGFR and ERBB2 Germline Mutations in Chinese Lung Cancer Patients and Their Roles in Genetic Susceptibility to Cancer","volume":"14","author":"Lu","year":"2019","journal-title":"J Thorac Oncol"},{"key":"2025083111041773000_11.1.e002571.34","doi-asserted-by":"crossref","first-page":"8018","DOI":"10.1200\/jco.2013.31.15_suppl.8018","article-title":"Response to erlotinib and prognosis for patients with de novo epidermal growth factor receptor (EGFR) T790M mutations","volume":"31","author":"Riely","year":"2013","journal-title":"JCO"},{"key":"2025083111041773000_11.1.e002571.35","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0b013e318250ed9d"},{"key":"2025083111041773000_11.1.e002571.36","doi-asserted-by":"crossref","DOI":"10.1038\/s41419-022-05259-w","article-title":"Interplays of glucose metabolism and KRAS mutation in pancreatic ductal adenocarcinoma","volume":"13","author":"Liu","year":"2022","journal-title":"Cell Death Dis"},{"key":"2025083111041773000_11.1.e002571.37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0021712","article-title":"Ras inhibition induces insulin sensitivity and glucose uptake","volume":"6","author":"Mor","year":"2011","journal-title":"PLoS One"},{"key":"2025083111041773000_11.1.e002571.38","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.jtho.2018.07.102","article-title":"Metformin Enhances Cisplatin-Induced Apoptosis and Prevents Resistance to Cisplatin in Co-mutated KRAS\/LKB1 NSCLC","volume":"13","author":"Moro","year":"2018","journal-title":"J Thorac Oncol"},{"key":"2025083111041773000_11.1.e002571.39","first-page":"3339","article-title":"Targeting oncogenic KRAS in non-small cell lung cancer cells by phenformin inhibits growth and angiogenesis","volume":"5","author":"Wang","year":"2015","journal-title":"Am J Cancer Res"},{"key":"2025083111041773000_11.1.e002571.40","doi-asserted-by":"crossref","first-page":"8645","DOI":"10.3390\/ijerph110908645","article-title":"Clinical and metabolic parameters in non-small cell lung carcinoma and colorectal cancer patients with and without KRAS mutations","volume":"11","author":"Yilmaz","year":"2014","journal-title":"Int J Environ Res Public Health"},{"key":"2025083111041773000_11.1.e002571.41","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0739-3"},{"key":"2025083111041773000_11.1.e002571.42","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.lungcan.2017.07.039","article-title":"PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort","volume":"112","author":"Sawa","year":"2017","journal-title":"Lung Cancer (Auckl)"},{"key":"2025083111041773000_11.1.e002571.43","doi-asserted-by":"publisher","DOI":"10.3978\/j.issn.2072-1439.2015.02.13"},{"key":"2025083111041773000_11.1.e002571.44","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10925-7"},{"key":"2025083111041773000_11.1.e002571.45","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.6879","article-title":"Association of Survival and Immune-Related Biomarkers With Immunotherapy in Patients With Non-Small Cell Lung Cancer: A Meta-analysis and Individual Patient-Level Analysis","volume":"2","author":"Yu","year":"2019","journal-title":"JAMA Netw Open"}],"container-title":["BMJ Open Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjresp-2024-002571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T18:04:28Z","timestamp":1756663468000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopenrespres.bmj.com\/lookup\/doi\/10.1136\/bmjresp-2024-002571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":45,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,12,4]]},"published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1136\/bmjresp-2024-002571"],"URL":"https:\/\/doi.org\/10.1136\/bmjresp-2024-002571","relation":{},"ISSN":["2052-4439"],"issn-type":[{"value":"2052-4439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]}}}