{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T20:04:58Z","timestamp":1788379498150,"version":"build-2803163510"},"reference-count":31,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T00:00:00Z","timestamp":1746921600000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2025,4,1]]},"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Tuberculosis preventive treatment (TPT) has been initiated systematically in Shanghai supported by a public health project. This study aimed to evaluate the acceptance of TPT, identify the factors related to its refusal, and find an optimal way to promote TPT among student tuberculosis (TB) contacts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We screened contacts of the TB index case from a TB outbreak on campus. A two-step approach of first conducting a lecture of TB health literacy, followed by one-on-one TPT consultations was used to mobilise TPT among students with latent TB infection (LTBI). A semistructured questionnaire was designed between the lecture and the one-on-one TPT consultations, covering general demographic information, awareness of core TB knowledge and willingness to accept TPT, along with the reasons for refusal. Logistic regression analysis was used to identify the risk factors for refusing TPT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 52 contacts were identified with LTBI. After the lecture on TB health literacy, their scores on the core TB knowledge was 14.0\u00b12.3. Students had a poor awareness rate of TB knowledge in the part of TB treatment and policy (70.2%) and\n                      <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                      infection preventive measures and LTBI (67.3%) compared with the average rate (84.3%). The acceptance rate of TPT reached 42.3% at the end of the two-step promotion. The main reasons for refusing TPT included: (1) the duration for TPT was too long and follow-up management was too cumbersome; (2) the confidence in their own immunity and belief in their low risk of TB and (3) the fear of side effects of TPT.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The two-step approach of first conducting a lecture of TB health literacy, followed by one-on-one TPT consultations, is effective for mobilising TPT. To further implement TPT, we recommend making the scientific popularisation for LTBI in a more easy-to-understand way and optimising the management of TPT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjresp-2024-002799","type":"journal-article","created":{"date-parts":[[2025,5,11]],"date-time":"2025-05-11T07:35:12Z","timestamp":1746948912000},"page":"e002799","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Cross-sectional study of preventive treatment for students with latent tuberculosis infection in Shanghai, China"],"prefix":"10.1136","volume":"12","author":[{"given":"Xiao","family":"Xiao","sequence":"first","affiliation":[{"name":"Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"},{"name":"Shanghai Academy of Preventive Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Li","sequence":"additional","affiliation":[{"name":"Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"},{"name":"Shanghai Academy of Preventive Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9099-9983","authenticated-orcid":false,"given":"Haoyue","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"},{"name":"Shanghai Academy of Preventive Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xin","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Pudong New Area Center for Disease Control and Prevention, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"},{"name":"Shanghai Academy of Preventive Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Shen","sequence":"additional","affiliation":[{"name":"Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"},{"name":"Shanghai Academy of Preventive Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[{"name":"Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China"},{"name":"Shanghai Academy of Preventive Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,5,11]]},"reference":[{"key":"2026010701503982000_12.1.e002799.1","doi-asserted-by":"crossref","first-page":"4457","DOI":"10.1038\/s41598-017-04788-1","article-title":"Tuberculosis infection in rural labor migrants in Shenzhen, China: Emerging challenge to tuberculosis control during urbanization","volume":"7","author":"Li","year":"2017","journal-title":"Sci Rep"},{"key":"2026010701503982000_12.1.e002799.2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S2213-2600(24)00083-3","article-title":"Effectiveness of preventive treatment among different age groups and Mycobacterium tuberculosis infection status: a systematic review and individual-participant data meta-analysis of contact tracing studies","volume":"12","author":"Martinez","year":"2024","journal-title":"Lancet Respir Med"},{"key":"2026010701503982000_12.1.e002799.3","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jinf.2012.03.018","article-title":"Use of the T-SPOT.TB assay to screen latent tuberculosis infection among the TB contacts in Shanghai, China","volume":"65","author":"Hu","year":"2012","journal-title":"J Infect"},{"key":"2026010701503982000_12.1.e002799.4","unstructured":"WHO . Global tuberculosis report 2024. Geneva World Health Organization; 2024."},{"key":"2026010701503982000_12.1.e002799.5","unstructured":"WH Organization . Recommendations for investigating contacts of persons with infectious tuberculosis in low- and middle-income countries. 2012."},{"key":"2026010701503982000_12.1.e002799.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0232OC"},{"key":"2026010701503982000_12.1.e002799.7","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)30216-X"},{"key":"2026010701503982000_12.1.e002799.8","first-page":"317","article-title":"Acceptance of Chemo-prophylaxis for Latent Tuberculosis Infection among High School\/College Student Contacts of Tuberculosis Patients in Shanghai, China","volume":"31","author":"Li","year":"2018","journal-title":"Biomed Environ Sci"},{"key":"2026010701503982000_12.1.e002799.9","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.1000663","article-title":"Prevalence of latent tuberculosis infection and incidence of active tuberculosis in school close contacts in Shanghai, China: Baseline and follow-up results of a prospective cohort 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WHO Consolidated Guidelines on Tuberculosis: Module 1: Prevention: Tuberculosis Preventive Treatment. 2nd edn. 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