{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T20:39:04Z","timestamp":1793479144544,"version":"4.5.0"},"reference-count":31,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2025,12,22]],"date-time":"2025-12-22T00:00:00Z","timestamp":1766361600000},"content-version":"unspecified","delay-in-days":21,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"InterMune"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2025,12,1]]},"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Interstitial lung diseases (ILDs) comprise a group of more than 200 different subtypes. They vary widely in terms of incidence, prognosis and treatment, yet real-life data from Germany are sparse.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The prospective Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases (EXCITING)-ILD registry included patients with all different ILD subtypes from different healthcare settings. Follow-up ranged from 36 months to 5 years. Data were analysed descriptively. Baseline characteristics, diagnostic and treatment information are presented as absolute numbers and percentages. The Wilcoxon signed-rank sum test was used to quantify differences between groups. Line plots and bar plots were used for graphical presentation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 601 patients (60.7% men, mean age 64.3 years) from 32 centres were included in the EXCITING-ILD registry. The most common subtypes were sarcoidosis with 26.6% (n=160) and idiopathic pulmonary fibrosis (IPF) with 25.3% (n=152). Pulmonary hypertension was present in 8.7% of patients (n=52), with high incidences in connective tissue disease-associated ILD (16.3%) and pneumoconiosis (27.3%). The mean forced vital capacity was 76.4% predicted, and the mean DLCO-SB (diffusing capacity for carbon monoxide) was 54.1% predicted. The mean time to diagnosis was 38.8 months (SD 64.4) and was significantly shorter when the diagnosis was made after multidisciplinary discussion (31.6 vs 49.2 months, p&lt;0.001). The frequency of surgical lung biopsies decreased over time in the registry, whereas the proportion of cryobiopsies showed a notable increase. In IPF, the number of patients treated with antifibrotics increased from 35.2% before 2015 to 48.4% in 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The EXCITING-ILD registry describes the frequency of ILD subtypes, ILD-related impairments, selected comorbidities and diagnostic and treatment patterns in a representative German population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjresp-2024-002902","type":"journal-article","created":{"date-parts":[[2025,12,25]],"date-time":"2025-12-25T09:30:19Z","timestamp":1766655019000},"page":"e002902","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Baseline characteristics from the EXCITING-ILD registry"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7598-5276","authenticated-orcid":false,"given":"Katharina","family":"Buschulte","sequence":"first","affiliation":[{"name":"Center for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany"},{"name":"German Center for Lung Research (DZL), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Kabitz","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Kantonsspital Aarau, Aarau, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Hagmeyer","sequence":"additional","affiliation":[{"name":"Clinic of Pneumology and Allergology, Center of Sleep Medicine and Respiratory Care, Hospital Bethanien Solingen, Solingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hammerl","sequence":"additional","affiliation":[{"name":"Chest Clinic Immenhausen, Immenhausen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Esselmann","sequence":"additional","affiliation":[{"name":"Outpatient Center for Pulmonology, Warendorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conrad","family":"Wiederhold","sequence":"additional","affiliation":[{"name":"Outpatient Center for Pulmonology, Fulda, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Skowasch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, University Hospital Bonn, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Stolpe","sequence":"additional","affiliation":[{"name":"Outpatient Center for Pulmonology, Ibbenb\u00fcren, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Joest","sequence":"additional","affiliation":[{"name":"Outpatient Center for Pulmonology and Allergology, Bonn, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Veitshans","sequence":"additional","affiliation":[{"name":"Outpatient Center for Pulmonology, B\u00f6blingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"H\u00f6ffgen","sequence":"additional","affiliation":[{"name":"Outpatient Center for Pulmonology, Rheine, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillen","family":"Maqhuzu","sequence":"additional","affiliation":[{"name":"Institute of Health Economics and Healthcare Management, Helmholtz Center Munich GmbH, Munich, Germany"},{"name":"German Center for Lung Research (DZL), Munich, Germany"},{"name":"Comprehensive Pneumology Center Munich (CPCM), Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larissa","family":"Schwarzkopf","sequence":"additional","affiliation":[{"name":"Institute of Health Economics and Healthcare Management, Helmholtz Center Munich GmbH, Munich, Germany"},{"name":"German Center for Lung Research (DZL), Munich, Germany"},{"name":"Center for Mental Health and Addiction Research, IFT Institut f\u00fcr Therapieforschung, Munich, Germany"},{"name":"Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilian University of Munich, Munich, Bayern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hellmann","sequence":"additional","affiliation":[{"name":"Outpatient Center for Pulmonology, Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Pfeifer","sequence":"additional","affiliation":[{"name":"Medical Clinic II, University of Regensburg and Klinikum Donaustauf, Donaustauf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Behr","sequence":"additional","affiliation":[{"name":"German Center for Lung Research (DZL), Munich, Germany"},{"name":"Department of Medicine V, LMU University Hospital, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Karpavicius","sequence":"additional","affiliation":[{"name":"Patient Support Group Lungenfibrose e.V, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Guenther","sequence":"additional","affiliation":[{"name":"Medical Clinic II, University Hospital Giessen, Universities of Giessen and Marburg Lung Center (UGMLC), Giessen, Germany"},{"name":"Pulmonary and Critical Care Medicine, Agaplesion Evangelisches Krankenhaus Mittelhessen, Giessen, Germany"},{"name":"German Center for Lung Research (DZL), Giessen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Polke","sequence":"additional","affiliation":[{"name":"Center for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany"},{"name":"German Center for Lung Research (DZL), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"H\u00f6ger","sequence":"additional","affiliation":[{"name":"Center for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany"},{"name":"German Center for Lung Research (DZL), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien","family":"Somogyi","sequence":"additional","affiliation":[{"name":"Mainz Center for Pulmonary Medicine, Departments of Pneumology, Mainz University Medical Center and of Pulmonary, Critical Care & Sleep Medicine, Marienhaus Clinic Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Lederer","sequence":"additional","affiliation":[{"name":"Center for Interstitial and Rare Lung Diseases, Pneumology and Respiratory Critical Care Medicine, Thoraxklinik, University of Heidelberg, Heidelberg, Germany"},{"name":"German Center for Lung Research (DZL), Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Markart","sequence":"additional","affiliation":[{"name":"Pulmonary and Critical Care Medicine, Agaplesion Evangelisches Krankenhaus Mittelhessen, Giessen, Germany"},{"name":"Medical Clinic V (Pneumology), Cardiothoracic Center, Universit\u00e4tsmedizin Marburg Campus Fulda, Fulda, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kreuter","sequence":"additional","affiliation":[{"name":"Mainz Center for Pulmonary Medicine, Departments of Pneumology, Mainz University Medical Center and of Pulmonary, Critical Care & Sleep Medicine, Marienhaus Clinic Mainz, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,12,25]]},"reference":[{"key":"2026010701522746000_12.1.e002902.1","unstructured":"Valeyre D , Duchemann B , Annesi-Maesano I , et al . Respiratory epidemiology. In: Welte T , Annesi-Maesano I , Viegi G , et al ., eds. Interstitial lung diseases."},{"key":"2026010701522746000_12.1.e002902.2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.2.ats01"},{"key":"2026010701522746000_12.1.e002902.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201308-1483ST"},{"key":"2026010701522746000_12.1.e002902.4","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0161-2022","article-title":"The world of rare interstitial lung diseases","volume":"32","author":"Buschulte","year":"2023","journal-title":"Eur Respir Rev"},{"key":"2026010701522746000_12.1.e002902.5","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/123876","article-title":"Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases: Rationale, Aims, and Design of a Nationwide Prospective Registry--The EXCITING-ILD Registry","volume":"2015","author":"Kreuter","year":"2015","journal-title":"Biomed Res Int"},{"key":"2026010701522746000_12.1.e002902.6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202202-0399ST"},{"key":"2026010701522746000_12.1.e002902.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908681"},{"key":"2026010701522746000_12.1.e002902.8","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-216732"},{"key":"2026010701522746000_12.1.e002902.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00217614"},{"key":"2026010701522746000_12.1.e002902.10","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02571-2021","article-title":"Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry","volume":"60","author":"Hambly","year":"2022","journal-title":"Eur Respir J"},{"key":"2026010701522746000_12.1.e002902.11","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02718-2020"},{"key":"2026010701522746000_12.1.e002902.12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12931-024-02731-3","article-title":"Disease trajectories in interstitial lung diseases \u2013 data from the EXCITING-ILD registry","volume":"25","author":"Buschulte","year":"2024","journal-title":"Respir Res"},{"key":"2026010701522746000_12.1.e002902.13","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1055\/s-2006-944326","article-title":"Guidelines for diagnosing extrinsic allergic alveolitis (hypersensitivity pneumonitis) (German Extrinsic Allergic Alveolitis Study Group)","volume":"61","author":"Sennekamp","year":"2007","journal-title":"Pneumologie"},{"key":"2026010701522746000_12.1.e002902.14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.2009-040GL"},{"key":"2026010701522746000_12.1.e002902.15","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1474"},{"key":"2026010701522746000_12.1.e002902.16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/17843286.1995.11718459","article-title":"Epidemiology of interstitial lung disease (ILD) in flanders: registration by pneumologists in 1992-1994. Working group on ILD, VRGT. Vereniging voor Respiratoire Gezondheidszorg en Tuberculosebestrijding","volume":"50","author":"Roelandt","year":"1995","journal-title":"Acta Clin Belg"},{"key":"2026010701522746000_12.1.e002902.17","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2001.026"},{"key":"2026010701522746000_12.1.e002902.18","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40557"},{"key":"2026010701522746000_12.1.e002902.19","unstructured":"ERS - European Respiratory Society . The European lung white book. Available: https:\/\/www.ersnet.org\/the-european-lung-white-book\/ [Accessed 2 Jun 2024]."},{"key":"2026010701522746000_12.1.e002902.20","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.4.7921471"},{"key":"2026010701522746000_12.1.e002902.21","doi-asserted-by":"crossref","DOI":"10.1186\/s12890-019-0986-4","article-title":"Baseline characteristics and comorbidities in the CAnadian REgistry for Pulmonary Fibrosis","volume":"19","author":"Fisher","year":"2019","journal-title":"BMC Pulm Med"},{"key":"2026010701522746000_12.1.e002902.22","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-023-02588-y","article-title":"Hospitalisation patterns in interstitial lung diseases: data from the EXCITING-ILD registry","volume":"25","author":"Buschulte","year":"2024","journal-title":"Respir Res"},{"key":"2026010701522746000_12.1.e002902.23","doi-asserted-by":"crossref","DOI":"10.1186\/s12890-017-0560-x","article-title":"Barriers to timely diagnosis of interstitial lung disease in the real world: the INTENSITY survey","volume":"18","author":"Cosgrove","year":"2018","journal-title":"BMC Pulm Med"},{"key":"2026010701522746000_12.1.e002902.24","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S2213-2600(21)00017-5","article-title":"Early diagnosis of fibrotic interstitial lung disease: challenges and opportunities","volume":"9","author":"Spagnolo","year":"2021","journal-title":"Lancet Respir Med"},{"key":"2026010701522746000_12.1.e002902.25","doi-asserted-by":"publisher","DOI":"10.1023\/B:EJEP.0000017660.18541.83"},{"key":"2026010701522746000_12.1.e002902.26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S2213-2600(19)30342-X","article-title":"Diagnostic accuracy of transbronchial lung cryobiopsy for interstitial lung disease diagnosis (COLDICE): a prospective, comparative study","volume":"8","author":"Troy","year":"2020","journal-title":"Lancet Respir Med"},{"key":"2026010701522746000_12.1.e002902.27","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)60405-4"},{"key":"2026010701522746000_12.1.e002902.28","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1402584"},{"key":"2026010701522746000_12.1.e002902.29","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1113354"},{"key":"2026010701522746000_12.1.e002902.30","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-022-01981-3","article-title":"Comorbidities in unclassifiable interstitial lung disease","volume":"23","author":"Prior","year":"2022","journal-title":"Respir Res"},{"key":"2026010701522746000_12.1.e002902.31","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209909"}],"container-title":["BMJ Open Respiratory Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjresp-2024-002902","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T09:54:26Z","timestamp":1767779666000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopenrespres.bmj.com\/lookup\/doi\/10.1136\/bmjresp-2024-002902"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12,25]]},"published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1136\/bmjresp-2024-002902"],"URL":"https:\/\/doi.org\/10.1136\/bmjresp-2024-002902","relation":{},"ISSN":["2052-4439"],"issn-type":[{"value":"2052-4439","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]}}}