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Current literature was reviewed and a practical approach suggested based on expert consensus. Dilemmas discussed included: (1) how to manage a breathless patient; (2) what to do if CTEPH is suspected; (3) the difference between CTEPH and post-PE syndrome, (4) testing for thrombophilia, (5) when to investigate for cancer, (6) anticoagulation duration and dose, (7) approaches to discussions and decision-making with respect to anticoagulation, (8) use of aspirin and whether antiplatelet therapy should be stopped during anticoagulation and (9) advice for patients on discharge from hospital at 3 months and information for first-degree relatives. Given the occurrence of complications that may require assessment, follow-up of patients post-PE should be systematic and consider the individual needs of the patient.<\/jats:p>","DOI":"10.1136\/bmjresp-2024-003028","type":"journal-article","created":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T06:25:18Z","timestamp":1758695118000},"page":"e003028","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Practical guide to management after an acute pulmonary embolism"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-1149","authenticated-orcid":false,"given":"Raza","family":"Alikhan","sequence":"first","affiliation":[{"name":"Division of Population Medicine, Cardiff University School of Medicine, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2822-210X","authenticated-orcid":false,"given":"Luke S","family":"Howard","sequence":"additional","affiliation":[{"name":"National Pulmonary Hypertension Service, Hammersmith Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Johnson","sequence":"additional","affiliation":[{"name":"Scottish Pulmonary Vascular Unit, Golden Jubilee National Hospital, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shruti","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Medical Affairs Department, Janssen-Cilag, High Wycombe, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G","family":"Kiely","sequence":"additional","affiliation":[{"name":"Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"},{"name":"University of Sheffield and NIHR Biomedical Research Centre, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Pepke-Zaba","sequence":"additional","affiliation":[{"name":"Pulmonary Vascular Diseases Unit, National Pulmonary Hypertension Service, Royal Papworth Hospital, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,9,23]]},"reference":[{"key":"2026010701510992000_12.1.e003028.1","unstructured":"National Institute for Health and Care Excellence . 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