{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T05:37:36Z","timestamp":1794375456811,"version":"4.9.0"},"reference-count":39,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:00:00Z","timestamp":1767657600000},"content-version":"unspecified","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011022","name":"Vertex Pharmaceuticals","doi-asserted-by":"publisher","award":["Vertex Pharmaceuticals Innovation Award (reference"],"award-info":[{"award-number":["Vertex Pharmaceuticals Innovation Award (reference"]}],"id":[{"id":"10.13039\/100011022","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2025,12,7]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Yoga is an emerging exercise choice for people with cystic fibrosis (CF), but evidence of its effect in this population is scarce, with a recent systematic review advocating for further research.\n                      <jats:underline>Y<\/jats:underline>\n                      oga\n                      <jats:underline>O<\/jats:underline>\n                      utcomes\n                      <jats:underline>G<\/jats:underline>\n                      et\n                      <jats:underline>A<\/jats:underline>\n                      ssessed in\n                      <jats:underline>CF<\/jats:underline>\n                      (YOGA-CF) is a real-world multicentre randomised controlled trial (RCT) investigating a bespoke CF-specific online 12-week yoga intervention, vers usual care, to determine effectiveness for adults with CF.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A multicentre RCT of adults with CF across the UK. Participants are randomised to usual care or a 12-week online bespoke yoga programme with an expectation of two classes completed weekly. Assessments of lung function, 1\u2009min sit-to-stand, the Cystic Fibrosis Questionnaire-Revised (CFQ-R) and other trial questionnaires are completed preintervention and postintervention (0 and 12 weeks) and after 12\u2009weeks of follow-up (week 24). The primary outcome is the difference in respiratory-related quality of life measured using the CFQ-R before and after yoga\/control. Sample size was calculated based on detecting a minimally clinically important difference of 4 for the CFQ-R respiratory domain, with power of 80% and 5%\u2009significance level (total target, n=314).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethics approval gained from the South Yorkshire and Humber Research Ethics Committee (REC) (reference: 23\/YH\/0270, project ID 303898). Dissemination to involve direct participant feedback and lay webinar, scientific conference presentation and publication in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT06120465\">NCT06120465<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjresp-2025-003405","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T15:40:17Z","timestamp":1767714017000},"page":"e003405","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Yoga Outcomes Get Assessed in Cystic Fibrosis (YOGA-CF): protocol of a multicentre interventional randomised controlled clinical trial\u2014investigating effects of a 12-week yoga intervention for adults with cystic fibrosis"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct06120465","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct06120465","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6967-6883","authenticated-orcid":false,"given":"Gemma E","family":"Stanford","sequence":"first","affiliation":[{"name":"Department of Adult Cystic Fibrosis, Royal Brompton Hospital, Guy's and St Thomas\u2019 Hospitals NHS Trust, London, England, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Scarborough","sequence":"additional","affiliation":[{"name":"Independent Yoga & Cystic Fibrosis Expert, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C","family":"Charman","sequence":"additional","affiliation":[{"name":"Cystic Fibrosis Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory A","family":"Cameron","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, England, UK"},{"name":"NIHR Applied Research Collaboration East of England, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P","family":"Wagner","sequence":"additional","affiliation":[{"name":"Norwich Medical School, University of East Anglia, Norwich, England, UK"},{"name":"NIHR Applied Research Collaboration East of England, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J","family":"Simmonds","sequence":"additional","affiliation":[{"name":"Department of Adult Cystic Fibrosis, Royal Brompton Hospital, Guy's and St Thomas\u2019 Hospitals NHS Trust, London, England, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,1,6]]},"reference":[{"key":"2026010607401364000_13.1.e003405.1","unstructured":"Cystic Fibrosis Trust . 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