{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:56:06Z","timestamp":1773827766983,"version":"3.50.1"},"reference-count":34,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"unspecified","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-000598-00"],"award-info":[{"award-number":["MOH-000598-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","award":["MOH-001451-00"],"award-info":[{"award-number":["MOH-001451-00"]}],"id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019579","name":"SingHealth","doi-asserted-by":"publisher","award":["02\/FY2020\/P1\/14-A29"],"award-info":[{"award-number":["02\/FY2020\/P1\/14-A29"]}],"id":[{"id":"10.13039\/100019579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2025,12,12]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Paediatric acute respiratory distress syndrome (PARDS) is a heterogeneous condition and identifying a specific biomarker remains a challenge. We aimed to validate the association of plasma soluble receptor for advanced glycation end-products (sRAGE) and angiopoietin-2 (Ang-2) with PARDS diagnosis, and its prognostic performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective observational study included children with PARDS and non-PARDS critical illness. Plasma sRAGE and Ang-2 levels were measured using enzyme-linked immunosorbent assays. Comparisons were made between PARDS versus non-PARDS critical illness and survivors versus non-survivors. Multivariable logistic regression was used to determine the association between biomarkers and intensive care unit (ICU) mortality after adjusting for age and the Pediatric Index of Mortality 3 score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>93 and 117 patients with PARDS and non-PARDS critical illness, respectively, were included in this study. Plasma sRAGE was higher in PARDS versus non-PARDS critical illness (2981 (1027 to 6198) vs 1575 (864 to 2994) pg\/mL; p=0.002) and in non-survivors vs survivors (5323 (1647 to 8261) vs 1601 (864 to 3572); p&lt;0.001). Plasma Ang-2 was elevated in non-survivors versus survivors (3054 (1760 to 6808) vs 1748 (845 to 3868); p=0.002), though there was no difference between PARDS and non-PARDS groups. In the multivariable model, sRAGE demonstrated an independent association with PARDS diagnosis (adjusted OR (aOR) 1.01 95%\u2009CI 1.01 to 1.02; p=0.003) and ICU mortality (aOR 1.02 (95% CI 1.01 to 1.03); p&lt;0.001), whereas there was no association observed with Ang-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Within an ICU cohort, only sRAGE demonstrated an association with the diagnosis of PARDS and ICU mortality, which remained after controlling for confounders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjresp-2025-003630","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T08:35:31Z","timestamp":1767688531000},"page":"e003630","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Validation of plasma soluble receptor of advanced glycation end-products and angiopoietin-2 in paediatric acute respiratory distress syndrome"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7987-4303","authenticated-orcid":false,"given":"Judith Ju Ming","family":"Wong","sequence":"first","affiliation":[{"name":"Children\u2019s Intensive Care Unit, KK Women's and Children\u2019s Hospital, Singapore"},{"name":"Duke-NUS Medical School, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herng Lee","family":"Tan","sequence":"additional","affiliation":[{"name":"Respiratory Therapy Service, Division of Allied Health Specialties, KK Women\u2019s and Children\u2019s Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7386-2231","authenticated-orcid":false,"given":"Clare","family":"Foo","sequence":"additional","affiliation":[{"name":"Children\u2019s Intensive Care Unit, KK Women's and Children\u2019s Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rehana","family":"Sultana","sequence":"additional","affiliation":[{"name":"Duke-NUS Medical School Centre for Quantitative Medicine, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yee Hui","family":"Mok","sequence":"additional","affiliation":[{"name":"Children\u2019s Intensive Care Unit, KK Women's and Children\u2019s Hospital, Singapore"},{"name":"Duke-NUS Medical School, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Albani","sequence":"additional","affiliation":[{"name":"SingHealth Duke-NUS Translational Immunology Institute, Singapore"},{"name":"Division of Medicine, KK Women's and Children\u2019s Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Guan","family":"Yeo","sequence":"additional","affiliation":[{"name":"SingHealth Duke-NUS Translational Immunology Institute, Singapore"},{"name":"Division of Medicine, KK Women's and Children\u2019s Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"2026010600352631000_13.1.e003630.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90168-7"},{"key":"2026010600352631000_13.1.e003630.2","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.trsl.2020.06.010","article-title":"The acute respiratory distress syndrome biomarker pipeline: crippling gaps between discovery and clinical utility","volume":"226","author":"Bime","year":"2020","journal-title":"Transl Res"},{"key":"2026010600352631000_13.1.e003630.3","doi-asserted-by":"crossref","unstructured":"Dong H , Zhang Y , Huang Y , et al . 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Biomarker Potential of the Soluble Receptor for Advanced Glycation End Products to Predict Bronchopulmonary Dysplasia in Premature Newborns. 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