{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:10:35Z","timestamp":1781007035288,"version":"3.54.1"},"reference-count":61,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"unspecified","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR302900"],"award-info":[{"award-number":["NIHR302900"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Resp Res"],"accepted":{"date-parts":[[2026,3,22]]},"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The epidemiology of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      -related chronic lung disease remains poorly defined. We aimed to characterise the local burden at Imperial College Healthcare National Health Service Trust, London, across a 10-year period (2014\u20132024).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Electronic health records were reviewed to identify individuals tested for serological markers of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      species infection after which thoracic CT scans were reviewed for features of\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      -related chronic lung disease. Patients were classified into diagnostic categories based on definitions provided in the recent British Thoracic Society Clinical Statement.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 334 individuals met criteria for serologic allergic bronchopulmonary aspergillosis (sABPA), 145 for ABPA, 74 for chronic pulmonary aspergillosis (CPA), 38 for simple aspergilloma and 11 with CPA-ABPA overlap. Serological responses varied: ABPA patients had higher median\n                      <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      -specific immunoglobulin (Ig)E titres (7.52 kUA\/L, vs 1.94 kUA\/L, p&lt;0.05) and a greater proportion were positive for\n                      <jats:italic>Aspergillus<\/jats:italic>\n                      antibody (IgG) or precipitins (62.5% vs 32.9%, p&lt;0.05) compared with sABPA. CPA patients had lower median total IgE (94 vs 1494\u2009IU\/mL, p&lt;0.05) and\n                      <jats:italic>A. fumigatus<\/jats:italic>\n                      -specific IgE (2.24 vs 7.52\u2009kUA\/L, p&lt;0.05) than ABPA patients. There was a wide spectrum of radiological presentations across diagnostic categories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While case numbers are likely underestimated, our findings highlight a substantial and heterogeneous local burden. This improved understanding of local epidemiology will inform our local service development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjresp-2025-003997","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T11:55:22Z","timestamp":1781006122000},"page":"e003997","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Describing the burden and characteristics of\n                    <i>Aspergillus<\/i>\n                    -related chronic lung disease at Imperial College Healthcare Trust: a 10-year retrospective study"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7733-2308","authenticated-orcid":false,"given":"Tim","family":"Venkatesan","sequence":"first","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navjeet","family":"Nagi","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Nwankwo","sequence":"additional","affiliation":[{"name":"Pharmacy Department, Royal Brompton Hospital, Guy's and St Thomas\u2019 NHS Foundation Trust, London, England, UK"},{"name":"Department of Infectious Disease Epidemiology, MRC Centre of Global Infectious Disease Analysis, Imperial College London School of Public Health, London, England, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Armstrong-James","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, England, UK"},{"name":"Department of Infectious Diseases, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Coleman","sequence":"additional","affiliation":[{"name":"Imperial College Healthcare NHS Trust, London, England, UK"},{"name":"Department of Infectious Diseases, Imperial College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,6,9]]},"reference":[{"key":"2026060904551304000_13.1.e003997.1","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00274-07"},{"key":"2026060904551304000_13.1.e003997.2","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/j.rmed.2015.09.007","article-title":"Development of chronic pulmonary aspergillosis in adult asthmatics with ABPA","volume":"109","author":"Lowes","year":"2015","journal-title":"Respir Med"},{"key":"2026060904551304000_13.1.e003997.3","doi-asserted-by":"crossref","unstructured":"Li S , Li Y , Li Z , et al . 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