{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T20:10:11Z","timestamp":1756671011846,"version":"3.44.0"},"reference-count":33,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Sport Exerc Med"],"accepted":{"date-parts":[[2016,8,2]]},"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To identify degenerative knee abnormalities using MRI and radiography 6\u2005years after knee trauma, their relation with persistent knee symptoms and baseline prognostic factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adults (18\u201365\u2005years) with incident traumatic knee symptoms visiting their general practitioner were followed up for 6\u2005years and underwent baseline MRI and 6-year follow-up MRI and radiography. Logistic regression was used to analyse associations between various degenerative abnormalities on 6-year MRI and radiography, persistent knee symptoms and baseline prognostic factors for knee osteoarthritis (OA) on 6-year MRI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>On 6-year radiography, 60% of patients showed no OA, 28% showed OA with Kellgren&amp;Lawrence (K&amp;L) grade 1 and 13% showed with K&amp;L grade 2. On 6-year MRI, 55% of patients showed cartilage defect(s), 45% showed osteophyte(s), 36% showed subchondral cyst(s), 40% showed bone marrow oedema, 21% showed meniscal subluxation, 83% showed meniscal degeneration,11% showed effusion and 11% showed a Baker's cyst. Of these, most were significantly related with 6-year radiographic K&amp;L grade, while only lateral cartilage defect(s), medial osteophyte(s) and medial meniscal subluxation were significantly related with persistent knee symptoms. 32% of patients showed new onset or progressive knee OA on 6-year MRI, for which age, history of non-traumatic knee symptoms and bone marrow oedema at baseline were independent prognostic factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Degenerative knee abnormalities on MRI are related to the K&amp;L score; however, not all abnormalities are reflected in clinical outcome. Age, history of non-traumatic knee symptoms and bone marrow oedema predict knee OA 6\u2005years after knee trauma, present in 32% of the patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjsem-2016-000153","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T23:43:38Z","timestamp":1474933418000},"page":"e000153","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Knee osteoarthritis in traumatic knee symptoms in general practice: 6-year cohort study"],"prefix":"10.1136","volume":"2","author":[{"given":"Marlous","family":"Kastelein","sequence":"first","affiliation":[{"name":"Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pim A J","family":"Luijsterburg","sequence":"additional","affiliation":[{"name":"Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ingrid M","family":"Koster","sequence":"additional","affiliation":[{"name":"Department of Radiology, Albert Schweitzer Hospital, Dordrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan A N","family":"Verhaar","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bart W","family":"Koes","sequence":"additional","affiliation":[{"name":"Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dammis","family":"Vroegindeweij","sequence":"additional","affiliation":[{"name":"Department of Radiology, Maasstad Hospital, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sita M A","family":"Bierma-Zeinstra","sequence":"additional","affiliation":[{"name":"Department of General Practice, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"},{"name":"Department of Orthopedics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin H G","family":"Oei","sequence":"additional","affiliation":[{"name":"Department of Radiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"2025083112432716000_2.1.e000153.1","unstructured":"van der Linden M , Westert G , de Bakker D , Schellevis F . 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