{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:38:04Z","timestamp":1787017084143,"version":"build-2736575974"},"reference-count":38,"publisher":"BMJ","issue":"1","funder":[{"name":"SINTEF unimed grant"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Sport Exerc Med"],"accepted":{"date-parts":[[2016,12,28]]},"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Three hours per week of vigorous physical activity is found to be associated with reduced odds of sleep-disordered breathing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether 12 weeks of high-intensity interval training (HIIT) reduced the apnoea\u2013hypopnea index (AHI) in obese subjects with moderate-to-severe obstructive sleep apnoea.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In a prospective randomised controlled exercise study, 30 (body mass index 37\u00b16\u2009kg\/m\n                      <jats:sup>2<\/jats:sup>\n                      , age 51\u00b19\u2009years) patients with sleep apnoea (AHI 41.5\u00b125.3 events\/hour) were randomised 1:1 to control or 12 weeks of supervised HIIT (4\u00d74\u2009min of treadmill running or walking at 90%\u201395% of maximal heart rate two times per week).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In the HIIT group, the AHI was reduced by 7.5\u00b111.6 events\/hour (within-group p&lt;0.05), self-reported sleepiness (Epworth scale) improved from 10.0\u00b13.6 to 7.3\u00b13.7 (between-group p&lt;0.05) and maximal oxygen uptake improved from 28.2\u00b17.4 to 30.2\u00b17.7\u2009mL\/kg\/min (between-group p&lt;0.05) from baseline to 12 weeks. The AHI, self-reported sleepiness and VO\n                      <jats:sub>2max<\/jats:sub>\n                      were unchanged from baseline to 12 weeks in controls (baseline AHI 50.3\u00b125.5\u2009events\/hour, Epworth score 5.9\u00b14.3, maximal oxygen uptake 27.0\u00b16.8\u2009mL\/kg\/min). Body weight remained unchanged in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Twelve weeks of HIIT improved the AHI and self-reported daytime sleepiness in subjects with obese sleep apnoea without any change in the desaturation index and body weight.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjsem-2016-000155","type":"journal-article","created":{"date-parts":[[2017,2,8]],"date-time":"2017-02-08T21:00:37Z","timestamp":1486587637000},"page":"bmjsem-2016-000155","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":21,"title":["High-intensity interval training improves obstructive sleep apnoea"],"prefix":"10.1136","volume":"2","clinical-trial-number":[{"clinical-trial-number":"nct01215617","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct01215617","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Trine","family":"Karlsen","sequence":"first","affiliation":[{"name":"K.G. 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