{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:37:17Z","timestamp":1787017037460,"version":"build-2736575974"},"reference-count":36,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Sport Exerc Med"],"accepted":{"date-parts":[[2019,10,7]]},"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The primary aim of the present study was to investigate the effects of aerobic interval training (AIT) versus moderate intensity continuous exercise (MICE) on aerobic exercise capacity (V\u0307O2peak), in women only, with coronary artery disease (CAD) and who were referred to a large, 24-week outpatient cardiac rehabilitation (CR) programme. Secondary objectives included comparing the effects of AIT versus MICE on cognition, cardiovascular risk profile, adherence and quality of life before and after the 24-week CR programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Thirty-one postmenopausal women with CAD (left ventricular ejection fraction &gt;35%; 68.2\u00b19.2 years of age; V\u0307O2peak: 19.1\u00b13.5 mL kg\n                      <jats:sup>-1<\/jats:sup>\n                      min\n                      <jats:sup>-1<\/jats:sup>\n                      ) were randomised to 24 weeks of usual care MICE (60%\u201380% of V\u0307O2peak, five times per week) or AIT (four 4-min intervals at 90%\u201395% of peak heart rate, three times per week+two times per week usual care MICE). Differences between and within groups were assessed using independent samples t-tests and paired samples t-tests, respectively. Treatment effect analysis of AIT on V\u0307O2peak and secondary outcomes was determined using analysis of covariance with baseline values as covariates.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A randomised controlled trial study design was unfeasible in this female CAD population. Unanticipated challenges in recruitment availability and eligibility, in combination with a 59% and 50% attrition rate in the AIT and MICE group, respectively, rendered this study underpowered to detect differences between groups. The per protocol treatment effect analysis, however, unveiled a 0.95 mL kg\n                      <jats:sup>-1<\/jats:sup>\n                      min\n                      <jats:sup>-1<\/jats:sup>\n                      improvement in V\u0307O2peak in response to AIT over MICE (p&lt;0.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Further research is necessary to elucidate the patient profile and circumstances under which the potential for the implementation of AIT may be individualised, and offered in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02966158\">NCT02966158<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjsem-2019-000589","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T10:25:18Z","timestamp":1571739918000},"page":"e000589","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Randomised controlled trial in women with coronary artery disease investigating the effects of aerobic interval training versus moderate intensity continuous exercise in cardiac rehabilitation: CAT versus MICE study"],"prefix":"10.1136","volume":"5","clinical-trial-number":[{"clinical-trial-number":"nct02966158","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4541-3939","authenticated-orcid":false,"given":"Leanna S","family":"Lee","sequence":"first","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Ontario, Canada"},{"name":"Cardiac Rehabilitation, Toronto Rehabilitation Institute - Rumsey Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Chang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Biomechanics and Performance Analysis, Canadian Sport Institute Pacific, Victoria, British Colombia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dina","family":"Brooks","sequence":"additional","affiliation":[{"name":"Institute of Medical Science, University of Toronto, Ontario, Canada"},{"name":"Cardiac Rehabilitation, Toronto Rehabilitation Institute - Rumsey Centre, Toronto, Ontario, Canada"},{"name":"Rehabilitation Sciences Institute, University of Toronto, Toronto, Ontario, Canada"},{"name":"School of Rehabilitation Science, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I","family":"Oh","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation, Toronto Rehabilitation Institute - Rumsey Centre, Toronto, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"2025083112170445000_5.1.e000589.1","unstructured":"Organisation WH . 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