{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T18:40:10Z","timestamp":1756665610930,"version":"3.44.0"},"reference-count":31,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T00:00:00Z","timestamp":1681171200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100002129","name":"Heart Foundation","doi-asserted-by":"publisher","award":["2017T051"],"award-info":[{"award-number":["2017T051"]}],"id":[{"id":"10.13039\/100002129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Sport Exerc Med"],"accepted":{"date-parts":[[2023,3,29]]},"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Regular exercise training is an important factor in prevention of myocardial infarction (MI). However, little is known whether exercise engagement prior to MI is related to the magnitude of post-MI cardiac biomarker concentrations and clinical outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We tested the hypothesis that exercise engagement in the week prior MI is related to lower cardiac biomarker concentrations following ST-elevated MI (STEMI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We recruited hospitalised STEMI patients and assessed the amount of exercise engagement in the 7\u2009days preceding MI onset using a validated questionnaire. Patients were classified as \u2018exercise\u2019 if they performed any vigorous exercise in the week prior MI, or as \u2018control\u2019 if they did not. Post-MI peak concentrations of high-sensitive cardiac troponin T (peak-hs-cTnT) and creatine kinase (peak-CK) were examined. We also explored whether exercise engagement prior MI is related to the clinical course (duration of hospitalisation and incidence of in-hospital, 30-day and 6-month major adverse cardiac events (reinfarction, target vessel revascularisation, cardiogenic shock or death)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 98 STEMI patients were included, of which 16% (n=16) was classified as \u2018exercise\u2019, and 84% (n=82) as \u2018control\u2019. Post-MI peak-hs-cTnT and peak-CK concentrations were lower in the exercise group (941 (645\u20132925)\u2009ng\/mL; 477 (346\u20131402) U\/L, respectively) compared with controls (3136 (1553\u20134969)\u2009ng\/mL, p=0.010; 1055 (596\u20132019) U\/L, p=0.016, respectively). During follow-up, no significant differences were found between both groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Engagement in exercise is associated with lower cardiac biomarker peak concentrations following STEMI. These data could provide further support for the cardiovascular health benefits of exercise training.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjsem-2022-001488","type":"journal-article","created":{"date-parts":[[2023,4,11]],"date-time":"2023-04-11T11:16:00Z","timestamp":1681211760000},"page":"e001488","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Association between engagement in exercise training and peak cardiac biomarker concentrations following ST-elevation myocardial infarction"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3903-3657","authenticated-orcid":false,"given":"Iris Apolonia","family":"de Koning","sequence":"first","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3696-6267","authenticated-orcid":false,"given":"B M A","family":"van Bakel","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajar","family":"Rotbi","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert-Jan M","family":"Van Geuns","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboudumc, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G Etienne","family":"Cramer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboudumc, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe A M","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Radboudumc, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0747-4471","authenticated-orcid":false,"given":"Thijs","family":"Eijsvogels","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dick H J","family":"Thijssen","sequence":"additional","affiliation":[{"name":"Department of Medical BioSciences, Radboud University Medical Center, Nijmegen, the Netherlands"},{"name":"Centre for Cardiovascular Science, Liverpool John Moores University, Liverpool, 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