{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T15:09:41Z","timestamp":1775747381045,"version":"3.50.1"},"reference-count":42,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"unspecified","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R01HL122624-01"],"award-info":[{"award-number":["1R01HL122624-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open Sport Exerc Med"],"accepted":{"date-parts":[[2024,8,23]]},"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To determine whether weekly oral vitamin D supplementation influences grip strength, explosive leg power, cardiorespiratory fitness or spirometric lung volumes in Mongolian schoolchildren.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Multicentre, randomised, placebo-controlled clinical trial conducted in children aged 6\u201313 years at baseline attending 18 schools in Ulaanbaatar. The intervention was weekly oral doses of 14\u2009000\u2009IU vitamin D<jats:sub>3<\/jats:sub> (n=4418) or placebo (n=4433) for 3 years. Outcome measures were grip strength, standing long jump distance and serum 25-hydroxyvitamin D (25(OH)D) concentrations (determined in all participants), peak oxygen uptake (VO<jats:sub>2peak<\/jats:sub>, determined in a subset of 632 participants using 20 m multistage shuttle run tests) and spirometric outcomes (determined in a subset of 1343 participants).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>99.8% of participants had serum 25(OH)D concentrations &lt;75\u2009nmol\/L at baseline, and mean end-study 25(OH)D concentrations in children randomised to vitamin D versus placebo were 77.4 vs 26.7\u2009nmol\/L (mean difference 50.7\u2009nmol\/L, 95%\u2009CI 49.7 to 51.4). However, vitamin D supplementation did not influence mean grip strength, standing long jump distance, VO<jats:sub>2peak<\/jats:sub>, spirometric lung volumes or peak expiratory flow rate, either overall or within subgroups defined by sex, baseline 25(OH)D concentration &lt;25\u2009vs \u226525\u2009nmol\/L or calcium intake &lt;500\u2009vs \u2265500\u2009mg\/day.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>A 3-year course of weekly oral supplementation with 14\u2009000\u2009IU vitamin D<jats:sub>3<\/jats:sub> elevated serum 25(OH)D concentrations in Mongolian schoolchildren with a high baseline prevalence of vitamin D deficiency. However, this intervention did not influence grip strength, explosive leg power, peak oxygen uptake or spirometric lung volumes, either overall or in subgroup analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02276755\">NCT02276755<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjsem-2024-002018","type":"journal-article","created":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T19:35:14Z","timestamp":1727379314000},"page":"e002018","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of vitamin D supplementation on muscle strength and exercise capacity in Mongolian schoolchildren: secondary outcomes from a randomised controlled trial"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct02276755","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02276755","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct04641195","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Davaasambuu","family":"Ganmaa","sequence":"first","affiliation":[{"name":"Harvard Medical School, Boston, Massachusetts, USA"},{"name":"Harvard TH Chan School of Public Health, Boston, Massachusetts, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Hemmings","sequence":"additional","affiliation":[{"name":"University of Brighton, Brighton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David A","family":"Jolliffe","sequence":"additional","affiliation":[{"name":"Blizard Institute, Queen Mary University of London, London, 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