{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:42:45Z","timestamp":1792489365274,"version":"4.5.0"},"reference-count":24,"publisher":"BMJ","issue":"1","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Sex Reprod Health"],"accepted":{"date-parts":[[2025,8,9]]},"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Since 2020, legislation in Britain has allowed both mifepristone and misoprostol to be taken at home for early medical abortion (EMA). In England and Wales, legislation restricts this to 9+6 weeks, but in Scotland this is permitted up to 11+6 weeks. Data on the outcomes of EMA at home &gt;10 weeks\u2019 gestation is limited and so we aimed to establish the safety and efficacy of this in comparison with EMA in a hospital setting.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective review from our abortion service in Edinburgh, Scotland of outcomes of EMA at home versus hospital between 10+0 and 11+6 weeks' gestation over the 5-year period April 2020\u2013March 2025. The primary outcome was complete abortion rate. Secondary outcomes were rates of incomplete abortion, ongoing pregnancy and serious complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 371 EMAs occurred at this gestation (n=258\u2009home, n=113 hospital). Complete abortion rates were not statistically significantly different between groups: 251\/258 (97%) (95%\u2009CI: 94% to 99%) at home and 110\/113 (97%) (95%\u2009CI: 92% to 99%) in hospital. Neither incomplete abortion rates (home: 4\/258, 1.6%; hospital: 3\/113, 2.6%) nor ongoing pregnancy rates (home: 3\/258, 1.2%; hospital: 0\/113, 0%) were significantly different between groups. There was one case of haemorrhage requiring transfusion and three cases of infection receiving intravenous antibiotics, all in the at home group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>EMA at home between 10+0 and 11+6 weeks has the same high efficacy and safety as when conducted in hospital. Action is needed to extend EMA at home after 10 weeks' gestation to women across the rest of the UK and beyond.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjsrh-2025-202947","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T23:55:18Z","timestamp":1759449318000},"page":"57-62","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Safety and efficacy of early medical abortion at home between 10+0 and 11+6 weeks' gestation: a retrospective review"],"prefix":"10.1136","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-5427-2064","authenticated-orcid":false,"given":"Jacqueline","family":"Quinn","sequence":"first","affiliation":[{"name":"University of Edinburgh Medical Research Council (MRC) Centre for Reproductive Health, Edinburgh, UK"},{"name":"Chalmers Sexual Health Centre, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6597-1666","authenticated-orcid":false,"given":"John Joseph","family":"Reynolds-Wright","sequence":"additional","affiliation":[{"name":"University of Edinburgh Medical Research Council (MRC) Centre for Reproductive Health, Edinburgh, UK"},{"name":"Chalmers Sexual Health Centre, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"McCabe","sequence":"additional","affiliation":[{"name":"University of Edinburgh Medical Research Council (MRC) Centre for Reproductive Health, Edinburgh, UK"},{"name":"Chalmers Sexual Health Centre, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-2276","authenticated-orcid":false,"given":"Sharon T","family":"Cameron","sequence":"additional","affiliation":[{"name":"University of Edinburgh Medical Research Council (MRC) Centre for Reproductive Health, Edinburgh, UK"},{"name":"Chalmers Sexual Health Centre, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,10,2]]},"reference":[{"key":"2026102002201434000_52.1.57.1","unstructured":"Royal College of Obstetricians and Gynaecologists (RCOG) . Coronavirus (COVID-19) infection and abortion care. Version 3.1, 2020. Available: https:\/\/www.rcog.org.uk\/media\/bbhpl2qa\/2020-07-31-coronavirus-covid-19-infection-and-abortion-care.pdf [Accessed May 2025]."},{"key":"2026102002201434000_52.1.57.2","unstructured":"Rough E . House of Commons Library Research Briefing CBP-9496; Early medical abortion at home during and after the pandemic, 2025. Available: https:\/\/researchbriefings.files.parliament.uk\/documents\/CBP-9496\/CBP-9496.pdf [Accessed May 2025]."},{"key":"2026102002201434000_52.1.57.3","unstructured":"World Health Organization (WHO) . Abortion care guideline. 2022. Available: https:\/\/iris.who.int\/bitstream\/handle\/10665\/349316\/9789240039483-eng.pdf?sequence=1&isAllowed=y [Accessed May 2025]."},{"key":"2026102002201434000_52.1.57.4","unstructured":"Scottish Government . Consultation on future arrangements for early medical abortion at home, 2020. Available: https:\/\/www.gov.scot\/publications\/consultation-future-arrangements-early-medical-abortion-home\/pages\/4\/ [Accessed May 2025]."},{"key":"2026102002201434000_52.1.57.5","unstructured":"Welsh Government . The Abortion Act 1967 \u2013 Approval of a Class of Place for Treatment for the Termination of Pregnancy (Wales), 2020. Available: https:\/\/www.gov.wales\/sites\/default\/files\/publications\/2020-04\/approval-of-a-class-of-place-for-treatment-for-the-termination-of-pregnancy-wales-2020.pdf [Accessed May 2025]."},{"key":"2026102002201434000_52.1.57.6","unstructured":"Royal College of Obstetricians and Gynaecologists (RCOG) . The Care of Women Requesting Induced Abortion: Evidence-based Clinical Guideline No. 7, 2011. Available: https:\/\/www.rcog.org.uk\/guidance\/browse-all-guidance\/other-guidelines-and-reports\/the-care-of-women-requesting-induced-abortion-evidence-based-clinical-guideline-no-7\/ [Accessed May 2025]."},{"key":"2026102002201434000_52.1.57.7","unstructured":"Public Health Scotland . Termination of pregnancy statistics. Year ending December 2024. 2024. Available: https:\/\/publichealthscotland.scot\/publications\/termination-of-pregnancy-statistics\/termination-of-pregnancy-statistics-year-ending-december-2024\/#:~:text=The%20percentage%20of%20women%20accessing,services%20before%20nine%20weeks\u2019%20gestation [accessed May 2025]"},{"key":"2026102002201434000_52.1.57.8","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsrh-2020-200976"},{"key":"2026102002201434000_52.1.57.9","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13944"},{"key":"2026102002201434000_52.1.57.10","unstructured":"Scottish Government . Chief Medical Officer for Scotland. Abortion-updated approval on taking abortion medications outwith the hospital or clinic, 2024. Available: https:\/\/www.publications.scot.nhs.uk\/files\/cmo-2024-21.pdf [Accessed May 2025]."},{"key":"2026102002201434000_52.1.57.11","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsrh-2024-202289"},{"key":"2026102002201434000_52.1.57.12","unstructured":"NHS Lothian Maternity Guidelines . Medical abortion as a day case up to 12 weeks gestation [accessed via NHS Lothian intranet]. 2023."},{"key":"2026102002201434000_52.1.57.13","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.15553"},{"key":"2026102002201434000_52.1.57.14","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/1471-0528.16668","article-title":"Effectiveness, safety and acceptability of no-test medical abortion (termination of pregnancy) provided via telemedicine: a national cohort study","volume":"128","author":"Aiken","year":"2021","journal-title":"BJOG"},{"key":"2026102002201434000_52.1.57.15","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-073630","article-title":"Using telemedicine to improve early medical abortion at home (UTAH): a randomised controlled trial to compare telemedicine with in-person consultation for early medical abortion","volume":"13","author":"Reynolds-Wright","year":"2023","journal-title":"BMJ Open"},{"key":"2026102002201434000_52.1.57.16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1111\/aogs.14549","article-title":"Effectiveness and acceptability of home use of misoprostol for medical abortion up to 10\u2009weeks of pregnancy","volume":"102","author":"Podolskyi","year":"2023","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2026102002201434000_52.1.57.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2016.04.013"},{"key":"2026102002201434000_52.1.57.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2004.10.015"},{"key":"2026102002201434000_52.1.57.19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsrh-2018-200278"},{"key":"2026102002201434000_52.1.57.20","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.10.084046"},{"key":"2026102002201434000_52.1.57.21","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1111\/aogs.13537","article-title":"Expanding a woman\u2019s options to include home use of misoprostol for medical abortion up until 76 days: an observational study of efficacy and safety","volume":"98","author":"Larsson","year":"2019","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2026102002201434000_52.1.57.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2020.01.009"},{"key":"2026102002201434000_52.1.57.23","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.contraception.2020.05.012","article-title":"A repeat dose of misoprostol 800 mcg following mifepristone for outpatient medical abortion at 64\u201370 and 71\u201377 days of gestation: A retrospective chart review","volume":"102","author":"Dzuba","year":"2020","journal-title":"Contraception"},{"key":"2026102002201434000_52.1.57.24","doi-asserted-by":"crossref","DOI":"10.1186\/s12978-020-00914-x","article-title":"Early termination of pregnancy: differences in gestational age estimation using last menstrual period and ultrasound in Mexico","volume":"17","author":"Saavedra-Avendano","year":"2020","journal-title":"Reprod Health"}],"container-title":["BMJ Sexual &amp; Reproductive Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjsrh-2025-202947","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T09:20:47Z","timestamp":1792488047000},"score":1,"resource":{"primary":{"URL":"https:\/\/jfprhc.bmj.com\/lookup\/doi\/10.1136\/bmjsrh-2025-202947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,2]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1,15]]},"published-print":{"date-parts":[[2026,1]]}},"alternative-id":["10.1136\/bmjsrh-2025-202947"],"URL":"https:\/\/doi.org\/10.1136\/bmjsrh-2025-202947","relation":{},"ISSN":["2515-1991","2515-2009"],"issn-type":[{"value":"2515-1991","type":"print"},{"value":"2515-2009","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,2]]}}}