{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:10:01Z","timestamp":1756361401046,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[1994,6]]},"abstract":"<jats:p>Periodontal disease is a major cause of tooth loss. The underlying pathology is inflammation caused by bacterial plaque affecting the supporting structures of the teeth.1 Conventional treatment involves mechanical debridement of calcified plaque (calculus) by the dentist combined with meticulous oral hygiene by the patient. A more recent approach is to apply antimicrobial drugs locally to the diseased gingival tissue after debridement. Two antibiotic preparations, minocycline 2% gel (Dentomycin - Lederle) and metronidazole 25% gel (Elyzol - Dumex), are now licensed for the treatment of patients with periodontal disease. Are these treatments an advance on conventional therapy?<\/jats:p>","DOI":"10.1136\/dtb.1994.32643","type":"journal-article","created":{"date-parts":[[2007,10,19]],"date-time":"2007-10-19T11:43:54Z","timestamp":1192794234000},"page":"43-44","source":"Crossref","is-referenced-by-count":2,"title":["Antibiotic gels for peridontal disease"],"prefix":"10.1136","volume":"32","member":"239","published-online":{"date-parts":[[1994,6,1]]},"reference":[{"key":"2025082722282270000_32.6.43.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1993.tb00224.x"},{"key":"2025082722282270000_32.6.43.2","unstructured":"Todd JE Lader E . The periodontal condition of the mouth Adult Dental Health London: HMSO 1988 131\u00e2\u0080\u009344."},{"key":"2025082722282270000_32.6.43.3","unstructured":"Moore WEC Ranney RR Holdeman LV . Subgingival microflora in periodontal disease: cultural studies Genco RJ Mergenhagen SE . Host-parasite Interactions in Periodontal Diseases Washington: American Society for Microbiology 1982 13\u00e2\u0080\u009326."},{"key":"2025082722282270000_32.6.43.4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.14219\/jada.archive.1991.0277","article-title":"Using antimicrobial agents to manage periodontal diseases","volume":"122","author":"Genco","year":"1991","journal-title":"J Am Dent Assoc"},{"key":"2025082722282270000_32.6.43.5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1993.tb00380.x"},{"key":"2025082722282270000_32.6.43.6","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/j.1365-2710.1992.tb01220.x","article-title":"Antibiotics in periodontal therapy: advantages and disadvantages","volume":"17","author":"Slots","year":"1990","journal-title":"J Clin Periodontol"},{"key":"2025082722282270000_32.6.43.7","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1136\/dtb.28.23.90","article-title":"Antibiotic prophylaxis of endocarditis: new recommendations","volume":"28","year":"1990","journal-title":"DTB"},{"key":"2025082722282270000_32.6.43.8","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1902\/jop.1990.61.4.228","article-title":"Susceptibility and resistance of plaque bacteria to minocycline","volume":"61","author":"O'Connor","year":"1990","journal-title":"J Periodontol"},{"key":"2025082722282270000_32.6.43.9","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1902\/jop.1993.64.7.637","article-title":"Subgingival minocycline hydrochloride ointment in moderate to severe chronic adult periodontitis: a randomized, double-blind, vehicle-controlled, multicenter study","volume":"64","author":"van Steenberghe","year":"1993","journal-title":"J Periodontol"},{"key":"2025082722282270000_32.6.43.10","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/j.1600-051X.1992.tb02531.x","article-title":"Concentration of metronidazole in periodontal pockets after applications of a metronidazole 25% dental gel","volume":"19","author":"Stoltze","year":"1992","journal-title":"J Clin Periodontol"},{"key":"2025082722282270000_32.6.43.11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1600-051X.1992.tb02530.x","article-title":"Systemic absorption of metronidazole after application of a metronidazole 25% dental gel","volume":"19","author":"Stoltze","year":"1992","journal-title":"J Clin Periodontol"},{"key":"2025082722282270000_32.6.43.12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1111\/j.1600-051X.1992.tb02534.x","article-title":"Comparative clinical and microbiological effects of topical subgingival application of metronidazole 25% dental gel and scaling in the treatment of adult periodontitis","volume":"19","author":"Pedrazzoli","year":"1992","journal-title":"J Clin Periodontol"},{"key":"2025082722282270000_32.6.43.13","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/j.1600-051X.1992.tb02535.x","article-title":"Clinical responses to subgingival application of a metronidazole 25% gel compared to the effect of subgingival scaling in adult periodontitis","volume":"19","author":"Ainamo","year":"1992","journal-title":"J Clin Periodontol"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.1994.32643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:28:27Z","timestamp":1756358907000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.1994.32643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,6]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1994,6,1]]},"published-print":{"date-parts":[[1994,6]]}},"alternative-id":["10.1136\/dtb.1994.32643"],"URL":"https:\/\/doi.org\/10.1136\/dtb.1994.32643","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[1994,6]]}}}