{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:12:56Z","timestamp":1761559976553,"version":"3.44.0"},"reference-count":13,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[1997,4]]},"abstract":"<jats:p>Budesonide is a glucocorticoid with high local activity but much lower systemic availability than prednisolone. Topical formulations have long been licensed for use in asthma and rhinitis. Here we discuss a new orally active controlled-release preparation of budesonide (Entocort CR - Astra) formulated specifically for treating patients with Crohn's disease affecting the ileum and\/or ascending colon. The manufacturer claims that the preparation \"targets the ileum and ileocaecal area, achieving rapid results equivalent to prednisolone\" with a \"low level of systemic steroid side effects\".<\/jats:p>","DOI":"10.1136\/dtb.1997.35430","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"30-31","source":"Crossref","is-referenced-by-count":4,"title":["Controlled-release budesonide in Crohn's disease"],"prefix":"10.1136","volume":"35","member":"239","published-online":{"date-parts":[[1997,4,1]]},"reference":[{"key":"2025082800253965000_35.4.30.1","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0016-5085(79)90385-8","article-title":"National Cooperative Crohn's Disease Study: results of drug treatment","volume":"77","author":"Summers","year":"1979","journal-title":"Gastroenterology"},{"key":"2025082800253965000_35.4.30.2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0016-5085(84)90409-8","article-title":"European Cooperative Crohn's Disease Study (ECCDS): results of drug treatment","volume":"86","author":"Malchow","year":"1984","journal-title":"Gastroenterology"},{"key":"2025082800253965000_35.4.30.3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/dtb.24.4.13","article-title":"The drug treatment of Crohn's disease","volume":"24","year":"1986","journal-title":"DTB"},{"key":"2025082800253965000_35.4.30.4","first-page":"74","article-title":"Topical and systemic glucocorticoid potencies of budesonide, beclomethasone dipropionate and prednisolone in man","volume":"63","author":"Andersson","year":"1982","journal-title":"Eur J Respir Dis"},{"key":"2025082800253965000_35.4.30.5","first-page":"86","article-title":"Pharmacokinetics and metabolism of budesonide, a selective glucocorticoid","volume":"63","author":"Ryrfeldt","year":"1982","journal-title":"Eur J Respir Dis"},{"key":"2025082800253965000_35.4.30.6","first-page":"A1019 [abstract]","article-title":"Budesonide reduces inflammation in a hamster model of ileitis","volume":"106","author":"Boyd","year":"1994","journal-title":"Gastroenterology"},{"key":"2025082800253965000_35.4.30.7","first-page":"A695 [abstract]","article-title":"Pharmacokinetics and gastrointestinal transit of budesonide controlled ileal release (CIR) capsules","volume":"104","author":"Edsb\u00c3\u00a4cker","year":"1993","journal-title":"Gastroenterology"},{"key":"2025082800253965000_35.4.30.8","first-page":"A51 [abstract]","article-title":"Food does not alter site of absorption of budesonide from controlled ileal release capsules","volume":"37","author":"Cvetkovic","year":"1995","journal-title":"Gut"},{"key":"2025082800253965000_35.4.30.9","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1056\/NEJM199409293311303","article-title":"Oral budesonide for active Crohn's disease","volume":"331","author":"Greenberg","year":"1994","journal-title":"N Engl J Med"},{"key":"2025082800253965000_35.4.30.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409293311303"},{"key":"2025082800253965000_35.4.30.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409293311304"},{"key":"2025082800253965000_35.4.30.12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1053\/gast.1996.v110.pm8536887","article-title":"Oral budesonide as maintenance treatment for Crohn's disease: a placebo-controlled, dose-ranging study","volume":"110","author":"Greenberg","year":"1996","journal-title":"Gastroenterology"},{"key":"2025082800253965000_35.4.30.13","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8536887"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.1997.35430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:25:49Z","timestamp":1756365949000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.1997.35430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,4]]},"references-count":13,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1997,4,1]]},"published-print":{"date-parts":[[1997,4]]}},"alternative-id":["10.1136\/dtb.1997.35430"],"URL":"https:\/\/doi.org\/10.1136\/dtb.1997.35430","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[1997,4]]}}}