{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:10:03Z","timestamp":1756361403363,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[1999,4]]},"abstract":"<jats:p>Primary biliary cirrhosis is a progressive chronic liver disease estimated to affect up to 1 in 4000 people in the UK.1 Patients with end-stage disease or an associated poor quality of life commonly need a liver transplant. Traditionally, drugs have offered little help as their benefits are modest and their unwanted effects unacceptable. Recently, the bile acid ursodeoxycholic acid has been used to treat primary biliary cirrhosis . Here we discuss the place of such therapy.<\/jats:p>","DOI":"10.1136\/dtb.1999.37430","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"30-32","source":"Crossref","is-referenced-by-count":4,"title":["Ursodeoxycholic acid for primary biliary cirrhosis"],"prefix":"10.1136","volume":"37","member":"239","published-online":{"date-parts":[[1999,4,1]]},"reference":[{"key":"2025082722374747000_37.4.30.1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1055\/s-2007-1007179","article-title":"The geoepidemiology of primary biliary cirrhosis","volume":"17","author":"Metcalf","year":"1997","journal-title":"Semin Liver Dis"},{"key":"2025082722374747000_37.4.30.2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/0016-5085(91)80033-6","article-title":"Primary biliary cirrhosis: paradigm or paradox for autoimmunity","volume":"100","author":"Gershwin","year":"1991","journal-title":"Gastroenterology"},{"key":"2025082722374747000_37.4.30.3","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S0140-6736(97)05419-6","article-title":"Primary biliary cirrhosis","volume":"350","author":"Neuberger","year":"1997","journal-title":"Lancet"},{"key":"2025082722374747000_37.4.30.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05419-6"},{"key":"2025082722374747000_37.4.30.5","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1056\/NEJM199611213352107","article-title":"Primary biliary cirrhosis","volume":"335","author":"Kaplan","year":"1996","journal-title":"N Engl J Med"},{"key":"2025082722374747000_37.4.30.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199611213352107"},{"key":"2025082722374747000_37.4.30.7","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/0016-5085(91)90085-Y","article-title":"Treatment of primary biliary cirrhosis with low-dose weekly methotrexate","volume":"101","author":"Kaplan","year":"1991","journal-title":"Gastroenterology"},{"key":"2025082722374747000_37.4.30.8","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0016-5085(94)90085-X","article-title":"Interstitial pneumonitis after low-dose methotrexate therapy in primary biliary cirrhosis","volume":"107","author":"Sharma","year":"1994","journal-title":"Gastroenterology"},{"key":"2025082722374747000_37.4.30.9","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1007\/BF01308413","article-title":"Gallstone dissolution with ursodeoxycholic acid in patients with chronic active hepatitis and two years follow-up. A pilot study","volume":"30","author":"Leuschner","year":"1985","journal-title":"Dig Dis Sci"},{"key":"2025082722374747000_37.4.30.10","doi-asserted-by":"publisher","DOI":"10.1007\/BF01308413"},{"key":"2025082722374747000_37.4.30.11","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1136\/gut.37.3.301","article-title":"The ursodeoxycholic acid story in primary biliary cirrhosis","volume":"37","author":"Lim","year":"1995","journal-title":"Gut"},{"key":"2025082722374747000_37.4.30.12","doi-asserted-by":"crossref","unstructured":"Paumgartne G . Ursodeoxycholic acid treatment of primary biliary cirrhosis: potential mechanisms of actionIn: Lindor KD, Heathcote EJ, Poupon R Primary biliary cirrhosis: from pathogenesis to clinical treatment Dordrecht: Kluwer Academic Publishers and Axcan Pharma 1998.","DOI":"10.1007\/978-94-011-4884-9_17"},{"key":"2025082722374747000_37.4.30.13","doi-asserted-by":"crossref","first-page":"1548","DOI":"10.1056\/NEJM199105303242204","article-title":"A multicenter, controlled trial of ursodiol for the treatment of primary biliary cirrhosis","volume":"324","author":"Poupon","year":"1991","journal-title":"N Engl J Med"},{"key":"2025082722374747000_37.4.30.14","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1056\/NEJM199405123301903","article-title":"Ursodiol for the long-term treatment of primary biliary cirrhosis","volume":"330","author":"Poupon","year":"1994","journal-title":"N Engl J Med"},{"key":"2025082722374747000_37.4.30.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405123301903"},{"key":"2025082722374747000_37.4.30.16","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(94)90861-3"},{"key":"2025082722374747000_37.4.30.17","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1053\/gast.1996.v110.pm8613058","article-title":"Effects of ursodeoxycholic acid on survival in patients with primary biliary cirrhosis","volume":"110","author":"Lindor","year":"1996","journal-title":"Gastroenterology"},{"key":"2025082722374747000_37.4.30.18","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8613058"},{"key":"2025082722374747000_37.4.30.19","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.4065\/72.12.1137","article-title":"Ursodeoxycholic acid delays the onset of esophageal varices in primary biliary cirrhosis","volume":"72","author":"Lindor","year":"1997","journal-title":"Mayo Clin Proc"},{"key":"2025082722374747000_37.4.30.20","doi-asserted-by":"publisher","DOI":"10.4065\/72.12.1137"},{"key":"2025082722374747000_37.4.30.21","doi-asserted-by":"publisher","DOI":"10.1016\/0270-9139(95)90294-5"},{"key":"2025082722374747000_37.4.30.22","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709000190"},{"key":"2025082722374747000_37.4.30.23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1994.tb01237.x"},{"key":"2025082722374747000_37.4.30.24","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90696-7"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.1999.37430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:37:55Z","timestamp":1756359475000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.1999.37430"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,4]]},"references-count":24,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1999,4,1]]},"published-print":{"date-parts":[[1999,4]]}},"alternative-id":["10.1136\/dtb.1999.37430"],"URL":"https:\/\/doi.org\/10.1136\/dtb.1999.37430","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[1999,4]]}}}