{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:02:48Z","timestamp":1756425768263,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[1999,6]]},"abstract":"<jats:p>Each year, around 11,000 women in the UK (around 1% of all pregnancies) present with an ectopic pregnancy,1 in which a fertilised ovum implants elsewhere than in the uterine cavity, usually a Fallopian tube. Left untreated, tubal ectopic pregnancy can lead to rupture of the Fallopian tube and life-threatening haemorrhage, and never results in a live birth. Improvements in management have led to a fall in the mortality rate from 2.9 per 1000 ectopic pregnancies in the early 1970s2 to 0.4 per 1000 in 1994-1996.1 Here we review the current management of tubal ectopic pregnancy.<\/jats:p>","DOI":"10.1136\/dtb.1999.37644","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"44-46","source":"Crossref","is-referenced-by-count":2,"title":["Management of ectopic pregnancy"],"prefix":"10.1136","volume":"37","member":"239","published-online":{"date-parts":[[1999,6,1]]},"reference":[{"key":"2025082800262106000_37.6.44.1","unstructured":"Department of Health, Welsh Office, Scottish Office Department of Health, Department of Health and Social Services, Northern Ireland . Report on confidential enquiries into maternal deaths in the United Kingdom 1994-96 London: HMSO 1998."},{"key":"2025082800262106000_37.6.44.2","unstructured":"Department of Health, Welsh Office, Scottish Home and Health Department, Department of Health and Social Services, Northern Ireland . Report on confidential enquiries into maternal deaths in the United Kingdom 1985-87 London: HMSO 1991."},{"key":"2025082800262106000_37.6.44.3","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S0015-0282(16)58320-4","article-title":"Risk factors for ectopic pregnancy: a meta-analysis","volume":"65","author":"Ankum","year":"1996","journal-title":"Fertil Steril"},{"key":"2025082800262106000_37.6.44.4","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0010-7824(95)00221-9","article-title":"Contraception and the risk of ectopic pregnancy: a meta-analysis","volume":"52","author":"Mol","year":"1995","journal-title":"Contraception"},{"key":"2025082800262106000_37.6.44.5","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(95)00221-9"},{"key":"2025082800262106000_37.6.44.6","first-page":"400","article-title":"Management of unruptured ectopic gestation by linear salpingostomy: a prospective, randomized clinical trial of laparoscopy versus laparotomy","volume":"73","author":"Vermesh","year":"1989","journal-title":"Obstet Gynecol"},{"key":"2025082800262106000_37.6.44.7","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0015-0282(16)55015-8","article-title":"Fertility outcome after conservative surgical treatment of ectopic pregnancy evaluated in a randomized trial","volume":"57","author":"Lundorff","year":"1992","journal-title":"Fertil Steril"},{"key":"2025082800262106000_37.6.44.8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1479-828X.1998.tb03081.x","article-title":"A casemix cost comparison of 2 treatments for ectopic pregnancy","volume":"38","author":"Lowe","year":"1998","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2025082800262106000_37.6.44.9","unstructured":"Braude PR Biswas C Nath Connell RJ . Setting up a UK hospital for the laparoscopic management of ectopic pregnancy Grudzinskas JG O'Brien PMS . Problems in early pregnancy. Advances in diagnosis and management London: RCOG Press 1997."},{"key":"2025082800262106000_37.6.44.10","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1093\/oxfordjournals.humrep.a138007","article-title":"Operative laparoscopy for ectopic pregnancy: how experienced should the surgeon be?","volume":"8","author":"Aharoni","year":"1993","journal-title":"Hum Reprod"},{"key":"2025082800262106000_37.6.44.11","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/"},{"key":"2025082800262106000_37.6.44.12","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0015-0282(97)80064-7","article-title":"Current status of surgical and nonsurgical management of ectopic pregnancy.","volume":"67","author":"Yao","year":"1997","journal-title":"Fertil Steril"},{"key":"2025082800262106000_37.6.44.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)80064-7"},{"key":"2025082800262106000_37.6.44.14","doi-asserted-by":"publisher","DOI":"10.1016\/0301-2115(95)02165-4"},{"key":"2025082800262106000_37.6.44.15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1093\/oxfordjournals.humrep.a136012","article-title":"Clearance curves of serum human chorionic gonadotrophin for the diagnosis of persistent trophoblast","volume":"10","author":"Hajenius","year":"1995","journal-title":"Hum Reprod"},{"key":"2025082800262106000_37.6.44.16","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/"},{"key":"2025082800262106000_37.6.44.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)05487-1"},{"key":"2025082800262106000_37.6.44.18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1479-828X.1998.tb02988.x","article-title":"A systematic review of single-dose intramuscular methotrexate for the treatment of ectopic pregnancy.","volume":"38","author":"Parker","year":"1998","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2025082800262106000_37.6.44.19","doi-asserted-by":"crossref","unstructured":"Hajenius PJ Mol BWJ Bossuyt PMM Ankum WM Van der Veen F . Interventions for tubal ectopic pregnancy (Cochrane Review) The Cochrane Library Issue 2 1999 Oxford: Update Software.","DOI":"10.1002\/14651858.CD000324"},{"key":"2025082800262106000_37.6.44.20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0015-0282(16)57290-2","article-title":"Limited role for intratubal methotrexate treatment of ectopic pregnancy","volume":"63","author":"Shalev","year":"1995","journal-title":"Fertil Steril"},{"key":"2025082800262106000_37.6.44.21","unstructured":"American College of Obstetricians and Gynecologists . Medical management of tubal pregnancy ACOG Practice Bulletin 1998 number 3."},{"key":"2025082800262106000_37.6.44.22","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/S0015-0282(16)57410-X","article-title":"Prognostic factors for successful expectant management of ectopic pregnancy","volume":"63","author":"Trio","year":"1995","journal-title":"Fertil Steril"},{"key":"2025082800262106000_37.6.44.23","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0015-0282(16)56638-2","article-title":"Serum human chorionic gonadotropin dynamics during spontaneous resolution of ectopic pregnancy","volume":"61","author":"Korhonen","year":"1994","journal-title":"Fertil Steril"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.1999.37644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T07:26:31Z","timestamp":1756365991000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.1999.37644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,6]]},"references-count":23,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1999,6,1]]},"published-print":{"date-parts":[[1999,6]]}},"alternative-id":["10.1136\/dtb.1999.37644"],"URL":"https:\/\/doi.org\/10.1136\/dtb.1999.37644","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[1999,6]]}}}