{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:21:28Z","timestamp":1756383688921,"version":"3.44.0"},"reference-count":37,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:p>Neuropathic pain results from damage to or dysfunction in the nervous system. The term usually refers to pain caused by a primary abnormality in the peripheral nervous system,while pain caused by damage to the central nervous system tends to be called central pain. Once established, neuropathic pain frequently runs a chronic course and can be severe and difficult to treat. Most doctors (but especially GPs, neurologists, neurosurgeons, oncologists and pain clinic specialists) will encounter patients with neuropathic pain. Management, ideally in a multidisciplinary pain-relief clinic, often involves the combined use of a range of pharmacological and non-drug approaches, the latter including transcutaneous electrical nerve stimulation, psychological treatments, and specialist procedures to stimulate, block or destroy discrete areas of the nervous system.1 Here, we review just the drug treatments for neuropathic pain.<\/jats:p>","DOI":"10.1136\/dtb.2000.381289","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"89-93","source":"Crossref","is-referenced-by-count":12,"title":["Drug treatment of neuropathic pain"],"prefix":"10.1136","volume":"38","member":"239","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2025082700495461000_38.12.89.1","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1136\/bmj.315.7112.867","article-title":"Difficult pain problems.","volume":"315","author":"Sykes","year":"1997","journal-title":"BMJ"},{"key":"2025082700495461000_38.12.89.2","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1001\/jama.280.21.1863","article-title":"Symptomatic treatment of painful neuropathy.","volume":"280","author":"Low","year":"1998","journal-title":"JAMA"},{"key":"2025082700495461000_38.12.89.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1863"},{"key":"2025082700495461000_38.12.89.4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7264.778"},{"key":"2025082700495461000_38.12.89.5","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1097\/00019052-199810000-00014","article-title":"Painful neuropathies.","volume":"11","author":"Koltzenburg","year":"1998","journal-title":"Curr Opin Neurol"},{"key":"2025082700495461000_38.12.89.6","doi-asserted-by":"publisher","DOI":"10.1097\/00019052-199810000-00014"},{"key":"2025082700495461000_38.12.89.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)01307-0"},{"key":"2025082700495461000_38.12.89.8","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(96)03140-5"},{"key":"2025082700495461000_38.12.89.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(99)00154-2"},{"key":"2025082700495461000_38.12.89.10","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370080078016"},{"key":"2025082700495461000_38.12.89.11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.18.1590"},{"key":"2025082700495461000_38.12.89.12","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1212\/WNL.51.4.1166","article-title":"Nortriptyline versus amitriptyline in postherpetic neuralgia. A randomized trial.","volume":"51","author":"Watson","year":"1998","journal-title":"Neurology"},{"key":"2025082700495461000_38.12.89.13","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0304-3959(92)90128-X","article-title":"Amitriptyline versus maprolitine in postherpetic neuralgia: a randomized, double-blind, crossover trial.","volume":"48","author":"Watson","year":"1992","journal-title":"Pain"},{"key":"2025082700495461000_38.12.89.14","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(92)90128-X"},{"key":"2025082700495461000_38.12.89.15","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/BF01212087","article-title":"Symptomatic treatment of peripheral diabetic neuropathy with carbamazepine (Tegretol): doubleblind crossover trial.","volume":"5","author":"Rull","year":"1969","journal-title":"Diabetologia"},{"key":"2025082700495461000_38.12.89.16","doi-asserted-by":"publisher","DOI":"10.1007\/BF01212087"},{"key":"2025082700495461000_38.12.89.17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/cpt1977222196","article-title":"Phenytoin in the treatment of diabetic symmetrical polyneuropathy.","volume":"22","author":"Saudek","year":"1977","journal-title":"Clin Pharmacol Ther"},{"key":"2025082700495461000_38.12.89.18","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1001\/jama.280.21.1837","article-title":"Gabapentin for the treatment of postherpetic neuralgia.","volume":"280","author":"Rowbotham","year":"1998","journal-title":"JAMA"},{"key":"2025082700495461000_38.12.89.19","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1837"},{"key":"2025082700495461000_38.12.89.20","doi-asserted-by":"publisher","DOI":"10.1001\/jama.280.21.1831"},{"key":"2025082700495461000_38.12.89.21","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.16.1931"},{"key":"2025082700495461000_38.12.89.22","doi-asserted-by":"publisher","DOI":"10.1016\/S0885-3924(00)00181-0"},{"key":"2025082700495461000_38.12.89.23","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(97)00104-8"},{"key":"2025082700495461000_38.12.89.24","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.54.11.2115"},{"key":"2025082700495461000_38.12.89.25","unstructured":"McQuay HJ, Moore RA. An Evidence-Based Resource for Pain Relief . Oxford: Oxford University Press, 1998."},{"key":"2025082700495461000_38.12.89.26","doi-asserted-by":"crossref","first-page":"691","DOI":"10.2165\/00003495-199856040-00016","article-title":"Mexiletine. A review of its therapeutic use in painful diabetic neuropathy.","volume":"56","author":"Jarvis","year":"1998","journal-title":"Drugs"},{"key":"2025082700495461000_38.12.89.27","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199856040-00016"},{"key":"2025082700495461000_38.12.89.28","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0190-9622(89)70171-7","article-title":"Topical capsaicin treatment of chronic postherpetic neuralgia.","volume":"21","author":"Bernstein","year":"1989","journal-title":"J Am Acad Dermatol"},{"key":"2025082700495461000_38.12.89.29","first-page":"510","article-title":"A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia.","volume":"15","author":"Watson","year":"1993","journal-title":"Clin Therapeutics"},{"key":"2025082700495461000_38.12.89.30","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/ana.410150306","article-title":"Baclofen in the treatment of trigeminal neuralgia: double-blind study and long-term follow-up.","volume":"15","author":"Fromm","year":"1984","journal-title":"Ann Neurol"},{"key":"2025082700495461000_38.12.89.31","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410150306"},{"key":"2025082700495461000_38.12.89.32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0304-3959(98)00256-5","article-title":"Are opioids effective in relieving neuropathic pain?","volume":"80","author":"Dellemijn","year":"1999","journal-title":"Pain"},{"key":"2025082700495461000_38.12.89.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3959(98)00256-5"},{"key":"2025082700495461000_38.12.89.34","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/S0140-6736(96)09024-1","article-title":"Randomised double-blind active-placebo-controlled cross over trial of intravenous fentanyl in neuropathic pain.","volume":"347","author":"Dellemijn","year":"1997","journal-title":"Lancet"},{"key":"2025082700495461000_38.12.89.35","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1212\/WNL.50.6.1837","article-title":"Efficacy of oxycodone in neuropathic pain. 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