{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:12Z","timestamp":1756339392566,"version":"3.44.0"},"reference-count":24,"publisher":"BMJ","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:p>Up to one-third of women in the UK have polycystic ovaries (i.e. 10 or more follicles per ovary detected on ultrasound).1 An estimated one-third of these women have polycystic ovary syndrome,2 usually defined in the UK as polycystic ovaries together with one or more characteristic features (hirsutism, male-pattern baldness, acne, oligomenorrhoea or amenorrhoea, obesity, or raised serum concentrations of testosterone and\/or luteinising hormone [LH]).3 The metabolic abnormalities often associated with polycystic ovary syndrome (insulin resistance and abnormal serum lipid concentrations) also put some women with the syndrome at increased risk of developing diabetes mellitus.4 Here, we review the management of women with polycystic ovary syndrome.<\/jats:p>","DOI":"10.1136\/dtb.2001.3911-a","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"1.2-5","source":"Crossref","is-referenced-by-count":1,"title":["Tackling polycystic ovary syndrome"],"prefix":"10.1136","volume":"39","member":"239","published-online":{"date-parts":[[2001,1,1]]},"reference":[{"key":"2025082701110341000_39.1.1-a.1","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S0140-6736(99)00218-4","article-title":"Pathogenesis of polycystic ovary syndrome - the enigma unravels?","volume":"354","author":"Balen","year":"1999","journal-title":"Lancet"},{"key":"2025082701110341000_39.1.1-a.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)00218-4"},{"key":"2025082701110341000_39.1.1-a.3","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1093\/oxfordjournals.humrep.a136243","article-title":"Polycystic ovary syndrome: the spectrum of the disorder in 1741 patients","volume":"10","author":"Balen","year":"1995","journal-title":"Hum Reprod"},{"key":"2025082701110341000_39.1.1-a.4","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/"},{"key":"2025082701110341000_39.1.1-a.5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2265.2000.01000.x","article-title":"Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study","volume":"52","author":"Wild","year":"2000","journal-title":"Clin Endocrinol"},{"key":"2025082701110341000_39.1.1-a.6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.01000.x"},{"key":"2025082701110341000_39.1.1-a.7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2265.1993.tb01744.x","article-title":"The impact of obesity on hyperandrogenism and polycystic ovary syndrome in premenopausal women","volume":"39","author":"Pasquali","year":"1993","journal-title":"Clin Endocrinol"},{"key":"2025082701110341000_39.1.1-a.8","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1111\/j.1365-2265.1989.tb01297.x","article-title":"Diet-induced changes in sex hormone binding globulin and free testosterone in women with normal or polycystic ovaries: correlation with serum insulin and insulin-like growth factor-I","volume":"31","author":"Kiddy","year":"1989","journal-title":"Clin Endocrinol"},{"key":"2025082701110341000_39.1.1-a.9","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1093\/oxfordjournals.humrep.a135772","article-title":"Weight loss results in significant improvement in pregnancy and ovulation rates in anovulatory obese women","volume":"10","author":"Clark","year":"1995","journal-title":"Hum Reprod"},{"key":"2025082701110341000_39.1.1-a.10","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/"},{"key":"2025082701110341000_39.1.1-a.11","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2265.1991.tb03489.x","article-title":"Cyproterone acetate for severe hirsutism: results of a double-blind dose-ranging study","volume":"35","author":"Barth","year":"1991","journal-title":"Clin Endocrinol"},{"key":"2025082701110341000_39.1.1-a.12","unstructured":"Lee O Farquhar C Toomath R Jepson R . Spironolactone versus placebo or in combination with steroids for hirsutism and\/or acne (Cochrane Review) The Cochrane Library Issue 4 2000 Oxford: Update Software."},{"key":"2025082701110341000_39.1.1-a.13","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1046\/j.1365-2265.2000.00982.x","article-title":"Spironolactone as a single agent for long-term therapy of hirsute patients","volume":"52","author":"Spritzer","year":"2000","journal-title":"Clin Endocrinol"},{"key":"2025082701110341000_39.1.1-a.14","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.2000.00982.x"},{"key":"2025082701110341000_39.1.1-a.15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.85.1.89"},{"key":"2025082701110341000_39.1.1-a.16","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0015-0282(99)00633-0","article-title":"Comparison of Diane 35 and Diane 35 plus finasteride in the treatment of hirsutism","volume":"73","author":"Tartagni","year":"2000","journal-title":"Fertil Steril"},{"key":"2025082701110341000_39.1.1-a.17","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00633-0"},{"key":"2025082701110341000_39.1.1-a.18","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/humupd\/3.4.359","article-title":"Modern use of clomiphene citrate in induction of ovulation","volume":"3","author":"Kousta","year":"1997","journal-title":"Hum Reprod Update"},{"key":"2025082701110341000_39.1.1-a.19","unstructured":"Royal College of Obstetricians and Gynaecologists. 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