{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:10:01Z","timestamp":1756361401576,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:p>Sickle cell disease is a recessively inherited condition in which synthesis of haemoglobin is abnormal. The disease, which occurs mainly in people of African, African-Caribbean, Indian, Mediterranean and Middle Eastern descent, is characterised by chronic anaemia, susceptibility to infection, bouts of severe pain and organ dysfunction. While the life expectancy for patients has improved, from a median survival age of 14 years in the 1970s among those homozygous for the sickle haemoglobin gene to survival into the mid-40s, childhood remains a period of peak mortality and morbidity.1 Here, we discuss the acute complications of sickle cell disease in children, concentrating on the management of the acutely unwell child.<\/jats:p>","DOI":"10.1136\/dtb.2001.39533","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"33-37","source":"Crossref","is-referenced-by-count":2,"title":["Acute complications of sickle cell disease in children"],"prefix":"10.1136","volume":"39","member":"239","published-online":{"date-parts":[[2001,5,1]]},"reference":[{"key":"2025082722475091000_39.5.33.1","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1056\/NEJM199406093302303","article-title":"Mortality in sickle cell disease. Life expectancy and risk factors for early death","volume":"330","author":"Platt","year":"1994","journal-title":"N Engl J Med"},{"key":"2025082722475091000_39.5.33.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302303"},{"key":"2025082722475091000_39.5.33.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199904013401307"},{"key":"2025082722475091000_39.5.33.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)07330-3"},{"key":"2025082722475091000_39.5.33.5","unstructured":"Report of a Working Party of the Standing Medical Advisory Committee on Sickle cell, Thalassaemia and other Haemoglobinopathies London: HMSO 1993."},{"key":"2025082722475091000_39.5.33.6","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1136\/bmj.312.7028.430","article-title":"Guidelines for the prevention and treatment of infection in patients with an absent or dysfunctional spleen","volume":"312","author":"Working Party of the British Committee for Standards in Haematology Clinical Haematology Task Force","year":"1996","journal-title":"BMJ"},{"key":"2025082722475091000_39.5.33.7","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1056\/NEJM198606193142501","article-title":"Prophylaxis with oral penicillin in children with sickle cell anemia. 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Hydroxyurea for sickle cell disease (Cochrane Review) The Cochrane Library Issue 2 2001 Oxford: Update Software."},{"key":"2025082722475091000_39.5.33.12","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0304-3959(94)00164-A","article-title":"Home management of sickle cell-related pain in children and adolescents: natural history and impact on school attendance","volume":"61","author":"Shapiro","year":"1995","journal-title":"Pain"},{"key":"2025082722475091000_39.5.33.13","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00164-A"},{"key":"2025082722475091000_39.5.33.14","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0268-960X(97)90012-6","article-title":"Blood transfusion in sickle cell disease","volume":"11","author":"Davies","year":"1997","journal-title":"Blood Rev"},{"key":"2025082722475091000_39.5.33.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0268-960X(97)90012-6"},{"key":"2025082722475091000_39.5.33.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)08462-6"},{"key":"2025082722475091000_39.5.33.17","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1056\/NEJM200006223422502","article-title":"Causes and outcomes of the acute chest syndrome in sickle cell disease","volume":"342","author":"Vichinsky","year":"2000","journal-title":"N Engl J Med"},{"key":"2025082722475091000_39.5.33.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200006223422502"},{"key":"2025082722475091000_39.5.33.19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199509143331104"},{"key":"2025082722475091000_39.5.33.20","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0022-3476(95)70204-0","article-title":"Risk of recurrent stroke in patients with sickle cell disease treated with erythrocyte transfusions","volume":"126","author":"Pegelow","year":"1995","journal-title":"J Pediatr"},{"key":"2025082722475091000_39.5.33.21","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70204-0"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2001.39533","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:47:58Z","timestamp":1756360078000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2001.39533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2001,5,1]]},"published-print":{"date-parts":[[2001,5]]}},"alternative-id":["10.1136\/dtb.2001.39533"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2001.39533","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}