{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:45Z","timestamp":1756339425853,"version":"3.44.0"},"reference-count":35,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:p>Each year in the UK, around 16,000 people die from colorectal cancer.1 At disease presentation, around 55% of people have advanced cancer that has spread to lymph nodes, metastasised to other organs or is so locally advanced that surgery is unlikely to be curative (Dukes' stage C or D).2 Overall 5-year survival for colorectal cancer in the UK is around 47-51%3 (compared to 64% in the USA4), but only 7% at most in those presenting with metastatic disease.5 These facts underlie the current introduction of national bowel screening programmes in the UK. Here we assess the role of screening of the general population in reducing mortality from colorectal cancer. We do not consider the screening arrangements needed for high-risk populations, including those with inflammatory bowel disease or a strong family history of colorectal cancer.2<\/jats:p>","DOI":"10.1136\/dtb.2006.44965","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"65-68","source":"Crossref","is-referenced-by-count":5,"title":["Population screening for colorectal cancer"],"prefix":"10.1136","volume":"44","member":"239","published-online":{"date-parts":[[2006,9,1]]},"reference":[{"key":"2025082702491886000_44.9.65.1","unstructured":"Cancer Research UK. 2006 UK Bowel Cancer statistics [online] Available: http:\/\/info.cancerresearchuk.org\/cancerstats\/types\/bowel\/ [Accessed 30 August 2006]."},{"key":"2025082702491886000_44.9.65.2","unstructured":"National Institute for Clinical Excellence. 2004 Guidance for cancer services. Improving Outcomes in Colorectal Cancer. Manual update [online] http:\/\/www.nice.org.uk\/page.aspx?o=CSGCCguidance [Accessed 30 August 2006]."},{"key":"2025082702491886000_44.9.65.3","unstructured":"Office for National Statistics. 2006 Five-year age-standardised1 relative survival (%) for adult2 patients3 diagnosed during 1991-95 and 1996-99 [online] http:\/\/www.statistics.gov.uk\/statbase\/Expodata\/Spreadsheets\/D7898.csv [Accessed 30 August 2006]."},{"key":"2025082702491886000_44.9.65.4","unstructured":"US National Institutes of Health, SEER. 2006 Cancer stat fact sheets - Cancer of the Colon and Rectum [online] http:\/\/seer.cancer.gov\/statfacts\/html\/colorect.html [Accessed 30 August 2006]."},{"key":"2025082702491886000_44.9.65.5","first-page":"37","article-title":"Bevacizumab and cetuximab for colorectal cancer","volume-title":"DTB","volume":"44","year":"2006"},{"key":"2025082702491886000_44.9.65.6","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1136\/jcp.35.8.830","article-title":"Pathology of colorectal adenomas: a colonoscopic survery","volume":"35","author":"Konishi","year":"1982","journal-title":"J Clin Pathol"},{"key":"2025082702491886000_44.9.65.7","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.8.830"},{"key":"2025082702491886000_44.9.65.8","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.2820360944"},{"key":"2025082702491886000_44.9.65.9","unstructured":"Pignone MP . 2002 HSTAT: screening for colorectal cancer in adults. Guide to clinical preventive services [online] http:\/\/www.ncbi.nlm.nih.gov\/books\/bv.fcgi?rid=hstat3.chapter.2359 [Accessed 30 August 2006]."},{"key":"2025082702491886000_44.9.65.10","first-page":"217","article-title":"Accuracy of occult blood tests over a six-day period","volume":"9","author":"Farrands","year":"1983","journal-title":"Clin Oncol"},{"key":"2025082702491886000_44.9.65.11","first-page":"150","article-title":"Meta-analysis of dietary restriction during fecal occult blood testing","volume":"4","author":"Pignone","year":"2001","journal-title":"Eff Clinl Pract"},{"key":"2025082702491886000_44.9.65.12","unstructured":"Towler BP . Screening for colorectal cancer using the faecal occult blood test, Hemoccult The Cochrane Database of Systematic Reviews."},{"key":"2025082702491886000_44.9.65.13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJM199305133281901","article-title":"Reducing mortality from colorectal cancer by screening for fecal occult blood","volume":"328","author":"Mandel","year":"1993","journal-title":"N Engl J Med"},{"key":"2025082702491886000_44.9.65.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199305133281901"},{"key":"2025082702491886000_44.9.65.15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03386-7"},{"key":"2025082702491886000_44.9.65.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)03430-7"},{"key":"2025082702491886000_44.9.65.17","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1056\/NEJM199312303292701","article-title":"Prevention of colorectal cancer by colonoscopic polypectomy","volume":"329","author":"Winawer","year":"1993","journal-title":"N Engl J Med"},{"key":"2025082702491886000_44.9.65.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312303292701"},{"key":"2025082702491886000_44.9.65.19","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.02.018"},{"key":"2025082702491886000_44.9.65.20","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.6.840"},{"key":"2025082702491886000_44.9.65.21","doi-asserted-by":"publisher","DOI":"10.1136\/gut.50.1.29"},{"key":"2025082702491886000_44.9.65.22","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.5.434"},{"key":"2025082702491886000_44.9.65.23","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432203"},{"key":"2025082702491886000_44.9.65.24","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.1800840922"},{"key":"2025082702491886000_44.9.65.25","doi-asserted-by":"publisher","DOI":"10.1007\/s003840050108"},{"key":"2025082702491886000_44.9.65.26","doi-asserted-by":"publisher","DOI":"10.1080\/003655299750026443"},{"key":"2025082702491886000_44.9.65.27","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/94.23.1763"},{"key":"2025082702491886000_44.9.65.28","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08268-5"},{"key":"2025082702491886000_44.9.65.29","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.4.413"},{"key":"2025082702491886000_44.9.65.30","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007203430301"},{"key":"2025082702491886000_44.9.65.31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200007203430302"},{"key":"2025082702491886000_44.9.65.32","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1148\/radiol.2373050176","article-title":"CT colonography in the detection of colorectal polyps and cancer: systematic review, meta-analysis, and proposed minimum data set for study level reporting","volume":"237","author":"Halligan","year":"2005","journal-title":"Radiology"},{"key":"2025082702491886000_44.9.65.33","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373050176"},{"key":"2025082702491886000_44.9.65.34","unstructured":"Department of Health. 2006 NHS Cancer Screening Programmes [online] http:\/\/www.cancerscreening.nhs.uk\/bowel\/news\/005.html [Accessed 30 August 2006]."},{"key":"2025082702491886000_44.9.65.35","unstructured":"Tappenden P . 2004 Colorectal cancer screening options appraisal. Cost-effectiveness, cost-utility and resource impact of alternative screening options for colorectal cancer. Report to the English Bowel Cancer Screening Working Group [online] School of Health and Related Research. Available: http:\/\/www.cancerscreening.nhs.uk\/bowel\/scharr.pdf [Accessed 30 August 2006]."}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2006.44965","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T09:49:30Z","timestamp":1756288170000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2006.44965"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2006,9,1]]},"published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1136\/dtb.2006.44965"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2006.44965","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2006,9]]}}}