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Topical negative pressure has been increasingly tried as an alternative for acute and chronic wounds.1 Here we discuss the value of this treatment for adults with chronic wounds (e.g. pressure ulcers, leg ulcers, foot ulcers related to diabetes mellitus).<\/jats:p>","DOI":"10.1136\/dtb.2007.45857","type":"journal-article","created":{"date-parts":[[2008,7,18]],"date-time":"2008-07-18T16:15:40Z","timestamp":1216397740000},"page":"57-61","source":"Crossref","is-referenced-by-count":5,"title":["Topical negative pressure for chronic wounds?"],"prefix":"10.1136","volume":"45","member":"239","published-online":{"date-parts":[[2007,8,1]]},"reference":[{"key":"2025082723183620000_45.8.57.1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.12968\/jowc.2006.15.6.26926","article-title":"The safety and efficacy of topical negative pressure in non-healing wounds: a systematic review.","volume":"15","author":"Pham","year":"2006","journal-title":"J Wound Care"},{"key":"2025082723183620000_45.8.57.2","unstructured":"Royal College of Nursing and National Institute for Health and Clinical Excellence. The management of pressure ulcers in primary and secondary care: A clinical practice guideline London. 2005."},{"key":"2025082723183620000_45.8.57.3","unstructured":"Banwell P . V.A.C.\u00c2\u00ae Therapy\u00e2\u0084\u00a2 Clinical guidelines New, revised edition. 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Plast Reconstr Surg 2006; 117 suppl pp S1216.","DOI":"10.1097\/01.prs.0000225450.12593.12"},{"key":"2025082723183620000_45.8.57.7","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.jvs.2006.07.030","article-title":"State-of-the-art treatment of chronic leg ulcers: a randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings.","volume":"44","author":"Vuerstaek","year":"2006","journal-title":"J Vasc Surg"},{"key":"2025082723183620000_45.8.57.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2006.07.030"},{"key":"2025082723183620000_45.8.57.9","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1067-1927.2004.12105.x","article-title":"Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial.","volume":"12","author":"Mou\u00c3\u00abs","year":"2004","journal-title":"Wound Rep Reg"},{"key":"2025082723183620000_45.8.57.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1067-1927.2004.12105.x"},{"key":"2025082723183620000_45.8.57.11","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000227675.63744.af"},{"key":"2025082723183620000_45.8.57.12","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200207000-00009"},{"key":"2025082723183620000_45.8.57.13","doi-asserted-by":"publisher","DOI":"10.1080\/713796078"},{"key":"2025082723183620000_45.8.57.14","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1007\/s10016-003-0065-3","article-title":"A prospective randomized evaluation of negative-pressure wound dressings for diabetic foot wounds.","volume":"17","author":"Eginton","year":"2003","journal-title":"Ann Vasc Surg"},{"key":"2025082723183620000_45.8.57.15","doi-asserted-by":"publisher","DOI":"10.1007\/s10016-003-0065-3"},{"key":"2025082723183620000_45.8.57.16","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67695-7"},{"key":"2025082723183620000_45.8.57.17","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/01.PRS.0000100813.39746.5A","article-title":"Development of new reconstructive techniques: use of Integra in combination with fibrin glue and negative-pressure therapy for reconstruction of acute and chronic wounds.","volume":"113","author":"Jeschke","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"2025082723183620000_45.8.57.18","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000100813.39746.5A"},{"key":"2025082723183620000_45.8.57.19","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000133168.57199.E1"},{"key":"2025082723183620000_45.8.57.20","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1046\/j.1365-2133.2000.03478.x","article-title":"A multicentre study of percentage change in venous leg ulcer area as a prognostic index of healing at 24 weeks.","volume":"142","author":"Kantor","year":"2000","journal-title":"Br J Dermatol"},{"key":"2025082723183620000_45.8.57.21","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2000.03478.x"},{"key":"2025082723183620000_45.8.57.22","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-200111000-00014"},{"key":"2025082723183620000_45.8.57.23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/j.1463-1318.2006.01154.x","article-title":"The use of vacuum-assisted closure abdominal wounds: a word of caution.","volume":"9","author":"Rao","year":"2007","journal-title":"Colorectal Dis"},{"key":"2025082723183620000_45.8.57.24","unstructured":"European Wound Management Association (EWMA). 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