{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:03:28Z","timestamp":1756461808393,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:p>Around 25% of women in the UK aged 16\u201349 years use oral contraception.1 Annually, around 5 million combined oral contraceptive (COC) items are prescribed in primary care in England alone, at a cost of over \u00a340 million. The effectiveness of such contraception depends on correct and consistent use of the pills and is influenced by unwanted effects that can lead to discontinuation (e.g. bleeding irregularities), and by adherence to specified procedures for when a pill is missed.1<jats:sup>,<\/jats:sup>2 \u25bcQlaira (Bayer plc) is the first licensed COC in the UK to include the oestrogen estradiol valerate (E2V, which is metabolised to oestradiol, a natural human hormone) and the progestogen dienogest (DNG).3 It has been marketed as \u201cthe first and only COC to deliver \u2026 the same oestrogen as produced by a woman\u2019s body\u201d.4 In theory, it might be less likely than other COCs to cause unwanted effects.3 However, it has a complex dosage regimen, and has its own missed-pill guidance which differs substantially from that for other pills.3 Here we review the effectiveness and place of Qlaira.<\/jats:p>","DOI":"10.1136\/dtb.2010.09.0045","type":"journal-article","created":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T11:25:08Z","timestamp":1283340308000},"page":"102-105","source":"Crossref","is-referenced-by-count":3,"title":["What role for \u25bcQlaira in contraception?"],"prefix":"10.1136","volume":"48","member":"239","published-online":{"date-parts":[[2010,9,1]]},"reference":[{"key":"2025082722220688000_48.9.102.1","unstructured":"National Institute for Health and Clinical Excellence, 2009. NICE implementation uptake report: long-acting reversible contraception (LARC) [online]. Available: http:\/\/www.nice.org.uk\/media\/386\/C2\/ImpUptakeReportCG30.pdf [Accessed 19 August 2010]."},{"key":"2025082722220688000_48.9.102.2","unstructured":"Regional Drug and Therapeutics Centre, 2009. New drug evaluation: Qlaira [online]. Available: http:\/\/www.nyrdtc.nhs.uk\/docs\/nde\/NDE_98_Qlaira_a.pdf [Accessed 19 August 2010]."},{"key":"2025082722220688000_48.9.102.3","unstructured":"Faculty of Sexual and Reproductive Healthcare Clinical Effectiveness Unit, 2009. The estradiol valerate\/dienogest combined pill, Qlaira [online]. Available: http:\/\/www.ffprhc.org.uk\/admin\/uploads\/CEU_Qlaira.pdf [Accessed 19 August 2010]."},{"key":"2025082722220688000_48.9.102.4","unstructured":"Qlaira advertisement. GP magazine, 15 May 2009."},{"key":"2025082722220688000_48.9.102.5","unstructured":"Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit, 2006. Clinical guidance. First prescription of combined oral contraception (Updated January 2007) [online]. Available: http:\/\/www.ffprhc.org.uk\/admin\/uploads\/FirstPrescCombOralContJan06.pdf [Accessed 19 August 2010]."},{"key":"2025082722220688000_48.9.102.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2009.08.010"},{"key":"2025082722220688000_48.9.102.7","doi-asserted-by":"crossref","unstructured":"Gallo MF . 20\u00ce\u00bcg versus >20\u00ce\u00bcg estrogen combined oral contraceptives for contraception. Cochrane Database Syst Rev 2008, Issue 4. Art. No.: CD003989. DOI: 10.1002\/14651858.CD003989.pub3. [Last assessed as up-to-date 5 February 2008].","DOI":"10.1002\/14651858.CD003989.pub3"},{"key":"2025082722220688000_48.9.102.8","unstructured":"Joint Formulary Committee. British National Formulary. Edition 59. London: Royal Pharmaceutical Society of Great Britain and British Medical Association, March 2010."},{"key":"2025082722220688000_48.9.102.9","unstructured":"European Medicines Agency, 2005. Guideline on clinical investigation of steroid contraceptives in women [online]. Available: http:\/\/www.ema.europa.eu\/pdfs\/human\/ewp\/051998en.pdf [Accessed 19 August 2010]."},{"key":"2025082722220688000_48.9.102.10","first-page":"558","article-title":"A guide to interpreting contraceptive efficacy studies","volume":"76","author":"Trussell","year":"1990","journal-title":"Obstet Gynecol"},{"key":"2025082722220688000_48.9.102.11","unstructured":"Qlaira. Summary of product characteristics, UK. Bayer plc, December 2008."},{"key":"2025082722220688000_48.9.102.12","doi-asserted-by":"publisher","DOI":"10.1783\/147118909788707878"},{"key":"2025082722220688000_48.9.102.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2008.05.004"},{"key":"2025082722220688000_48.9.102.14","first-page":"15S","article-title":"Efficacy and tolerability of a new oral contraceptive containing estradiol and dienogest","volume":"111","author":"Nahum","year":"2008","journal-title":"Obstet Gynecol"},{"key":"2025082722220688000_48.9.102.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2009.03.018"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2010.09.0045","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:22:14Z","timestamp":1756358534000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2010.09.0045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":15,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2010,9,1]]},"published-print":{"date-parts":[[2010,9]]}},"alternative-id":["10.1136\/dtb.2010.09.0045"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2010.09.0045","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}