{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:07:39Z","timestamp":1756382859549,"version":"3.44.0"},"reference-count":15,"publisher":"BMJ","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["DTB"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>Dupuytren's contracture is a benign, progressive disabling condition of the hands.12 Traditionally, surgery (e.g. fasciotomy, fasciectomy, joint fusion and amputation) has been the only effective treatment but it is not an option for every patient.34 A potential alternative intervention is a formulation of collagenase <jats:italic>Clostridium histolyticum<\/jats:italic> (\u25bcXiapex - Pfizer Limited), which has been licensed for injection directly into the affected joint as treatment for adults with Dupuytren's contracture.5 Here we review the evidence for collagenase <jats:italic>C. histolyticum<\/jats:italic> and discuss its place in the management of this condition.<\/jats:p>","DOI":"10.1136\/dtb.2011.02.0072","type":"journal-article","created":{"date-parts":[[2011,12,14]],"date-time":"2011-12-14T06:34:36Z","timestamp":1323844476000},"page":"138-141","source":"Crossref","is-referenced-by-count":1,"title":["\u25bcXiapex for Dupuytren's contracture"],"prefix":"10.1136","volume":"49","member":"239","published-online":{"date-parts":[[2011,12,14]]},"reference":[{"key":"2025082722353420000_49.12.138.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7538.397"},{"key":"2025082722353420000_49.12.138.2","unstructured":"NHS Choices, 2009. Dupuytren's Contracture [online]. Available: www.nhs.uk\/conditions\/dupuytrens-contracture\/Pages\/Introduction.aspx [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0810866"},{"key":"2025082722353420000_49.12.138.4","unstructured":"British Society for Surgery of the Hand, 2011. BSSH Evidence for Surgical Treatment 1 - Dupuytren's Disease [online]. Available: http:\/\/www.bssh.ac.uk\/education\/guidelines\/dd_guidelines.pdf [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.5","unstructured":"\u00e2\u0096\u00bcXiapex 0.9mg powder and solvent for solution for injection. Summary of Product Characteristics EU. Pfizer Limited. February 2011."},{"key":"2025082722353420000_49.12.138.6","unstructured":"Map of medicine Health Guides, 2010. Dupuytren's contracture \u00e2\u0080\u0093 assessment [online]. Available: http:\/\/healthguides.mapofmedicine.com\/choices\/map\/dupuytren_s_contracture1.html [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00145-6"},{"key":"2025082722353420000_49.12.138.8","unstructured":"National Institute for Health and Clinical Excellence, February 2004. Needle fasciotomy for Dupuytren's contracture, IPG 043 [online]. Available: http:\/\/www.nice.org.uk\/nicemedia\/live\/11116\/31124\/31124.pdf [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.9","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13871-8"},{"key":"2025082722353420000_49.12.138.10","unstructured":"Clinical Knowledge Summaries, 2011. Dupuytren's Disease [online]. Available: http:\/\/www.cks.nhs.uk\/dupuytrens_disease. [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.11","unstructured":"National Institute for Health and Clinical Excellence, November 2011. Radiation therapy for early Dupuytren's disease, IPG 368 [online]. Available: http:\/\/www.nice.org.uk\/nicemedia\/live\/12353\/51717\/51717.pdf [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.12","unstructured":"Xiapex collagenase clostridium histolyticum \u00e2\u0080\u0093 Injection Training Brochure [online]. Available: http:\/\/www.xiapex.co.uk [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.13","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.jhsa.2010.08.007","article-title":"Injectable collagenase clostridium histolyticum: a new nonsurgical treatment for Dupuytren's disease","volume":"35A","author":"Gilpin","year":"2010","journal-title":"J Hand Surg"},{"key":"2025082722353420000_49.12.138.14","unstructured":"North East Treatment Advisory Group, 2011. Collagenase (Xiapex\u00c2\u00ae) for Dupuytren's Contracture. Available: http:\/\/www.netag.nhs.uk\/files\/appraisal-reports\/Collagenase%20-Xiapex-%20for%20Dupuytrens%20contracture%20-%20NETAG%20appraisal%20report%20-%20Aug2011.pdf [Accessed 24 November 2011]."},{"key":"2025082722353420000_49.12.138.15","unstructured":"Scottish Medicines Consortium, 2011. Collagenase clostridium histolyticum 0.9mg powder and solvent for solution for injection (Xiapex\u00c2\u00ae) (SMC No. 715\/11) [online]. Available: http:\/\/www.scottishmedicines.org.uk\/files\/\/advice\/collagenase_clostridium_histolyticum_Xiapex_FINAL_July_2011_for_website_Amended_151111.pdf [Accessed 24 November 2011]."}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2011.02.0072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T05:35:45Z","timestamp":1756359345000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2011.02.0072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2011,12,14]]},"published-print":{"date-parts":[[2011,12]]}},"alternative-id":["10.1136\/dtb.2011.02.0072"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2011.02.0072","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}