{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:11:18Z","timestamp":1756383078638,"version":"3.44.0"},"reference-count":33,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["DTB"],"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:p>Premature ejaculation, also referred to as rapid or early ejaculation, is a poorly understood disorder with no single, widely-recognised, evidence-based definition. Studies based on patient self-reporting indicate that premature ejaculation is a common complaint with estimated prevalence ranging from 4%\u201339% of men in the general community.<jats:sup>1<\/jats:sup> However, a lack of an accurate validated definition has made comparison of the results of such studies difficult.<jats:sup>2<\/jats:sup> In addition, perception of normal ejaculatory latency varies by country and differs when assessed by the patient or their partner.<jats:sup>3<\/jats:sup> \u25bcDapoxetine (Priligy\u2014A. Menarini Farmaceutica Internazionale SRL), a short-acting selective serotonin reuptake inhibitor (SSRI) is the first drug to be licensed in the UK for on-demand management of diagnosed premature ejaculation.<jats:sup>4<\/jats:sup> In this article we review the evidence for dapoxetine and discuss some of the challenges associated with its introduction.<\/jats:p>","DOI":"10.1136\/dtb.2014.3.0240","type":"journal-article","created":{"date-parts":[[2014,3,13]],"date-time":"2014-03-13T04:42:58Z","timestamp":1394685778000},"page":"30-33","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["\u25bcDapoxetine for premature ejaculation"],"prefix":"10.1136","volume":"52","member":"239","published-online":{"date-parts":[[2014,3,13]]},"reference":[{"doi-asserted-by":"crossref","unstructured":"McMahon CG .Dapoxetine: a new option in the medical management of premature ejaculation. Ther Adv Urol 2012; 4: 233\u201351.","key":"2025082700085744000_52.3.30.1","DOI":"10.1177\/1756287212453866"},{"unstructured":"European Association of Urology, 2013. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation [online]. Available: http:\/\/www.uroweb.org\/gls\/pdf\/14_Male%20Sexual%20Dysfunction_LR.pdf [Accessed 19 February 2014].","key":"2025082700085744000_52.3.30.2"},{"issue":"(suppl 2)","key":"2025082700085744000_52.3.30.3","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1743-6109.2005.20369.x","article-title":"Prevalence of premature ejaculation: a global and regional perspective","volume":"2","author":"Montorsi","year":"2005","journal-title":"J Sex Med"},{"unstructured":"Priligy. Summary of product characteristics, UK. A. Menarini Farmaceutica Internazionale SRL, February 2013.","key":"2025082700085744000_52.3.30.4"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.5","DOI":"10.1111\/j.1743-6109.2008.00901.x"},{"doi-asserted-by":"crossref","unstructured":"American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders. Fifth edition (DSM-5). Washington, DC: American Psychiatric Publishing, 2013.","key":"2025082700085744000_52.3.30.6","DOI":"10.1176\/appi.books.9780890425596"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.7","DOI":"10.1111\/j.1743-6109.2010.01782.x"},{"unstructured":"American Psychiatric Association . Diagnostic and Statistical Manual of Mental Disorders (text revision). Fourth edition (DSM-IV-TR). Washington, DC: American Psychiatric Publishing, 2000.","key":"2025082700085744000_52.3.30.8"},{"key":"2025082700085744000_52.3.30.9","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.eururo.2006.05.055","article-title":"Serotonin, premature ejaculation: from physiology to patient management","volume":"50","author":"Giuliano","year":"2006","journal-title":"Eur Urol"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.10","DOI":"10.1111\/j.1743-6109.2010.01820.x"},{"key":"2025082700085744000_52.3.30.11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CE.S13841","article-title":"Dapoxetine: an evidence-based review of its effectiveness in treatment of premature ejaculation","volume":"7","author":"McCarty","year":"2012","journal-title":"Core Evid"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.12","DOI":"10.1016\/S0140-6736(06)69373-2"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.13","DOI":"10.1016\/j.eururo.2009.01.025"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.14","DOI":"10.1111\/j.1743-6109.2009.01560.x"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.15","DOI":"10.1111\/j.1464-410X.2008.08165.x"},{"unstructured":"European Medicines Agency , 2012. Assessment report for Priligy and associated names [online]. Available: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Referrals_document\/Priligy_29\/WC500124578.pdf [Accessed 19 February 2014].","key":"2025082700085744000_52.3.30.16"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.17","DOI":"10.1111\/j.1743-6109.2010.02097.x"},{"key":"2025082700085744000_52.3.30.18","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1097\/01.WNF.0000228210.12194.46","article-title":"Comparison of dapoxetine versus paroxetine in patients with premature ejaculation: a double-blind, placebo-controlled, fixed-dose, randomized study","volume":"29","author":"Safarinejad","year":"2006","journal-title":"Clin Neuropharmacol"},{"key":"2025082700085744000_52.3.30.19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2165\/11598150-000000000-00000","article-title":"A benefit-risk assessment of dapoxetine in the treatment of premature ejaculation","volume":"35","author":"Hutchinson","year":"2012","journal-title":"Drug Saf"},{"doi-asserted-by":"crossref","unstructured":"Mirone V . Results from a prospective observational study of men with premature ejaculation treated with dapoxetine or alternative care: the PAUSE study. Eur Urol [Epub ahead of print] 22 August 2013; DOI:10.1016\/j.eururo.2013.08.018.","key":"2025082700085744000_52.3.30.20","DOI":"10.1016\/j.eururo.2013.08.018"},{"key":"2025082700085744000_52.3.30.21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1742-1241.2010.02479.x","article-title":"Update on treatments for premature ejaculation","volume":"65","author":"Hellstrom","year":"2011","journal-title":"Int J Clin Pract"},{"doi-asserted-by":"crossref","unstructured":"Melnik T . Psychosocial interventions for premature ejaculation. Cochrane Database Syst Rev 2011; 8: pCD008195. DOI:10.1002\/14651858.CD008195.pub2 [Last assessed as up-to-date 6 January 2011].","key":"2025082700085744000_52.3.30.22","DOI":"10.1002\/14651858.CD008195.pub2"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.23","DOI":"10.1111\/j.1464-410X.2003.04773.x"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.24","DOI":"10.1111\/j.1743-6109.2010.01975.x"},{"key":"2025082700085744000_52.3.30.25","doi-asserted-by":"crossref","first-page":"380","DOI":"10.5489\/cuaj.12002","article-title":"Evolving therapeutic strategies for premature ejaculation: the search for on-demand treatment\u2014topical versus systemic","volume":"6","author":"Morales","year":"2012","journal-title":"Can Urol Assoc J"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.26","DOI":"10.1111\/j.1464-410X.2009.08456.x"},{"doi-asserted-by":"crossref","unstructured":"Waldinger MD . Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis. Int J Impot Res 2004; 16: p369-81.","key":"2025082700085744000_52.3.30.27","DOI":"10.1038\/sj.ijir.3901172"},{"key":"2025082700085744000_52.3.30.28","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.urology.2013.05.018","article-title":"Dapoxetine treatment in patients with lifelong premature ejaculation: the reasons of a \u201cwaterloo\u201d","volume":"82","author":"Mondaini","year":"2013","journal-title":"Urology"},{"unstructured":"American Urological Association, 2004 (reviewed and validity confirmed 2010). Guideline on the pharmacologic management of premature ejaculation [online]. Available: http:\/\/www.auanet.org\/education\/guidelines\/premature-ejaculation.cfm [Accessed 19 February 2014].","key":"2025082700085744000_52.3.30.29"},{"doi-asserted-by":"publisher","key":"2025082700085744000_52.3.30.30","DOI":"10.1111\/j.1743-6109.2007.00528.x"},{"unstructured":"NHS Executive, 1999. Treatment for impotence [online]. Available: http:\/\/webarchive.nationalarchives.gov.uk\/20130107105354\/http:\/\/www.dh.gov.uk\/prod_consum_dh\/groups\/dh_digitalassets\/@dh\/@en\/documents\/digitalasset\/dh_4012086.pdf [Accessed 19 February 2014].","key":"2025082700085744000_52.3.30.31"},{"unstructured":"All Wales Medicines Strategy Group, 2012. dapoxetine (Priligy\u00ae) [online]. Available: http:\/\/www.awmsg.org\/awmsgonline\/app\/appraisalinfo\/1671 [Accessed 6 February 2014].","key":"2025082700085744000_52.3.30.32"},{"unstructured":"General Medical Council, 2013. Good practice in prescribing and managing medicines and devices (2013) [online]. Available: http:\/\/www.gmc-uk.org\/guidance\/ethical_guidance\/14316.asp [Accessed 19 February 2014].","key":"2025082700085744000_52.3.30.33"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2014.3.0240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:09:07Z","timestamp":1756278547000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2014.3.0240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,3,13]]},"published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1136\/dtb.2014.3.0240"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2014.3.0240","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}