{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T12:41:38Z","timestamp":1756384898721,"version":"3.44.0"},"reference-count":17,"publisher":"BMJ","issue":"10","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["DTB"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:p>Catephen (Kora Corporation Ltd) is a herbal medicinal product consisting predominantly of catechins (sinecatechins) extracted from <jats:italic>Camellia sinensis<\/jats:italic> (L.) O. Kuntze folium (green tea leaf) formulated as a topical preparation for the treatment of external genital and perianal warts (condylomata acuminata).<jats:sup>1<\/jats:sup> Marketing authorisation for an ointment containing 0.1g of green tea extract per gram (10%) was granted by the Medicines and Healthcare products Regulatory Agency (MHRA) under the mutual recognition procedure in February 2015.<jats:sup>2<\/jats:sup> Here, we consider the evidence for Catephen ointment in the management of external genital and perianal warts and its place within current management strategies.<\/jats:p>","DOI":"10.1136\/dtb.2015.10.0355","type":"journal-article","created":{"date-parts":[[2015,10,15]],"date-time":"2015-10-15T03:43:20Z","timestamp":1444880600000},"page":"114-116","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Green tea extract for external anogenital warts"],"prefix":"10.1136","volume":"53","member":"239","published-online":{"date-parts":[[2015,10,15]]},"reference":[{"key":"2025082723055946000_53.10.114.1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2165\/11209370-000000000-00000","article-title":"Polyphenon E 10% ointment","volume":"13","author":"Hoy","year":"2012","journal-title":"Am J Clin Dermtol"},{"unstructured":"Medigene, 2015. Medigene receives positive decision on marketing authorisation for Veregen\u00ae in 8 additional European countries [online]. Available: http:\/\/www.medigene.com\/presse-investoren\/news\/pressemitteilungen\/medigene-receives-positive-decision-on-marketing-authorisa [Accessed 23 September 2015].","key":"2025082723055946000_53.10.114.2"},{"key":"2025082723055946000_53.10.114.3","first-page":"e263","article-title":"European guideline for the management of anogenital warts","volume":"27","author":"Lacey","year":"2012","journal-title":"J Eur Acad Dermatol Venereol"},{"unstructured":"British Association for Sexual Health and HIV, 2007. United Kingdom national guideline on the management of anogenital warts, 2007 [online]. Available: http:\/\/www.bashh.org\/documents\/86\/86.pdf [Accessed 23 September 2015].","key":"2025082723055946000_53.10.114.4"},{"unstructured":"Public Health England, 2015. Infection report [online]. Available: https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/437433\/hpr2215_STI_NCSP_v6.pdf [Accessed 23 September 2015].","key":"2025082723055946000_53.10.114.5"},{"doi-asserted-by":"crossref","unstructured":"Patel H , et al . Systematic review of the incidence and prevalence of genital warts. BMC Infect Dis 2013; 13: 39.","key":"2025082723055946000_53.10.114.6","DOI":"10.1186\/1471-2334-13-39"},{"doi-asserted-by":"publisher","key":"2025082723055946000_53.10.114.7","DOI":"10.1258\/ijsa.2011.011218"},{"unstructured":"National Institute for Health and Care Excellence, 2012. Clinical Knowledge Summaries: Warts\u2014anogenital [online]. Available: http:\/\/cks.nice.org.uk\/warts-anogenital [Accessed 23 September 2015].","key":"2025082723055946000_53.10.114.8"},{"key":"2025082723055946000_53.10.114.9","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1586\/edm.13.24","article-title":"Current update on the treatment of genital warts","volume":"8","author":"Yanofsky","year":"2013","journal-title":"Expert Rev Dermatol"},{"unstructured":"Royal College of General Practitioners, 2013. Sexually transmitted infections in primary care 2013 [online]. Available: http:\/\/www.rcgp.org.uk\/clinical-and-research\/clinical-resources\/~\/media\/Files\/CIRC\/RCGP-Sexually-Transmitted-Infections-in-Primary-Care-2013.ashx [Accessed 23 September 2015].","key":"2025082723055946000_53.10.114.10"},{"doi-asserted-by":"publisher","key":"2025082723055946000_53.10.114.11","DOI":"10.1111\/j.1365-2133.2008.08520.x"},{"unstructured":"Kora Healthcare, 2015. Package leaflet: information for the user. Catephen\u00ae 10% ointment [online]. Available: http:\/\/www.mhra.gov.uk\/home\/groups\/spcpil\/documents\/spcpil\/con1427431527177.pdf [Accessed 23 September 2015].","key":"2025082723055946000_53.10.114.12"},{"unstructured":"Catephen 10% Ointment. Summary of product characteristics, UK. Kora Corporation Ltd t\/a Kora Healthcare, March 2015.","key":"2025082723055946000_53.10.114.13"},{"doi-asserted-by":"publisher","key":"2025082723055946000_53.10.114.14","DOI":"10.1097\/AOG.0b013e3181719b60"},{"doi-asserted-by":"publisher","key":"2025082723055946000_53.10.114.15","DOI":"10.1111\/j.1468-3083.2007.02441.x"},{"key":"2025082723055946000_53.10.114.16","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1468-3083.2010.03796.x","article-title":"Efficacy, safety and tolerability of green tea catechins in the treatment of external anogenital warts: a systematic review and meta-analysis","volume":"25","author":"Tzellos","year":"2011","journal-title":"J Eur Acad Dermatol Venereol"},{"unstructured":"Centers for Disease Control and Prevention, 2015. Sexually transmitted diseases treatment guidelines, 2015 [online]. Available: http:\/\/www.cdc.gov\/std\/tg2015\/tg-2015-print.pdf [Accessed 23 September 2015].","key":"2025082723055946000_53.10.114.17"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2015.10.0355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T06:06:11Z","timestamp":1756361171000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2015.10.0355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":17,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,10,15]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1136\/dtb.2015.10.0355"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2015.10.0355","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}