{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:03:21Z","timestamp":1756339401410,"version":"3.44.0"},"reference-count":40,"publisher":"BMJ","issue":"8","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["DTB"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1136\/dtb.2021.235608rep","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T13:21:03Z","timestamp":1621862463000},"page":"124-127","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Republished: Metformin-associated lactic acidosis: reinforcing learning points"],"prefix":"10.1136","volume":"59","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2793-309X","authenticated-orcid":false,"given":"Mohummad Shaan","family":"Goonoo","sequence":"first","affiliation":[{"name":"Diabetes and Endocrine Centre, Hadfield Wing, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Morris","sequence":"additional","affiliation":[{"name":"Critical Care Department, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Raithatha","sequence":"additional","affiliation":[{"name":"Critical Care Department, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fionuala","family":"Creagh","sequence":"additional","affiliation":[{"name":"Diabetes and Endocrine Centre, Hadfield Wing, Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,5,24]]},"reference":[{"key":"2025082701541866000_59.8.124.1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-817931"},{"key":"2025082701541866000_59.8.124.2","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1111\/dom.12974","article-title":"Metformin-Associated lactic acidosis (Mala): moving towards a new paradigm","volume":"19","author":"Lalau","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"2025082701541866000_59.8.124.3","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13181-012-0278-3","article-title":"Metformin-Associated lactic acidosis (Mala): case files of the Einstein medical center medical toxicology fellowship","volume":"9","author":"Kopec","year":"2013","journal-title":"J Med Toxicol"},{"key":"2025082701541866000_59.8.124.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2009.04.023"},{"key":"2025082701541866000_59.8.124.5","doi-asserted-by":"publisher","DOI":"10.2165\/11534750-000000000-00000"},{"key":"2025082701541866000_59.8.124.6","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.19"},{"key":"2025082701541866000_59.8.124.7","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-015-3844-9"},{"key":"2025082701541866000_59.8.124.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199508313330903"},{"key":"2025082701541866000_59.8.124.9","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/ael347"},{"key":"2025082701541866000_59.8.124.10","doi-asserted-by":"crossref","unstructured":"Salpeter SR , Greyber E , Pasternak GA . Salpeter (posthumous) ee. risk of fatal and non-fatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database of Systematic Review 2010:CD002967.","DOI":"10.1002\/14651858.CD002967.pub3"},{"key":"2025082701541866000_59.8.124.11","doi-asserted-by":"publisher","DOI":"10.1046\/j.0306-5251.2001.01423.x"},{"key":"2025082701541866000_59.8.124.12","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1171"},{"key":"2025082701541866000_59.8.124.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2007.11.055"},{"key":"2025082701541866000_59.8.124.14","doi-asserted-by":"crossref","first-page":"459","DOI":"10.3109\/0886022X.2011.568132","article-title":"Prolonged hemodialysis for severe metformin intoxication","volume":"33","author":"Rifkin","year":"2011","journal-title":"Ren Fail"},{"key":"2025082701541866000_59.8.124.15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s13181-012-0278-3","article-title":"Metformin-Associated lactic acidosis (Mala): case files of the Einstein medical center medical toxicology fellowship","volume":"9","author":"Kopec","year":"2013","journal-title":"J Med Toxicol"},{"key":"2025082701541866000_59.8.124.16","first-page":"390","article-title":"Metformin-Associated lactic acidosis (Mala): case report","volume":"66","author":"Hofkens","year":"2011","journal-title":"Acta Clin Belg"},{"key":"2025082701541866000_59.8.124.17","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1992.00400230129023"},{"key":"2025082701541866000_59.8.124.18","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1097\/CCM.0000000000001002","article-title":"Extracorporeal treatment for metformin poisoning: systematic review and recommendations from the extracorporeal treatments in poisoning Workgroup","volume":"43","author":"Calello","year":"2015","journal-title":"Crit Care Med"},{"key":"2025082701541866000_59.8.124.19","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1186\/cc11332","article-title":"Metformin overdose, but not lactic acidosis per se, inhibits oxygen consumption in pigs","volume":"16","author":"Protti","year":"2012","journal-title":"Crit Care"},{"key":"2025082701541866000_59.8.124.20","doi-asserted-by":"publisher","DOI":"10.1186\/cc8885"},{"key":"2025082701541866000_59.8.124.21","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/dom.12978","article-title":"Acute kidney injury, plasma lactate concentrations and lactic acidosis in metformin users: a GoDarts study","volume":"19","author":"Connelly","year":"2017","journal-title":"Diabetes Obes Metab"},{"key":"2025082701541866000_59.8.124.22","first-page":"511","article-title":"Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus","volume":"20","author":"Almani","year":"2017","journal-title":"Iran J Basic Med Sci"},{"key":"2025082701541866000_59.8.124.23","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-112-7-492"},{"key":"2025082701541866000_59.8.124.24","doi-asserted-by":"publisher","DOI":"10.1002\/jhm.542"},{"key":"2025082701541866000_59.8.124.25","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10871014"},{"key":"2025082701541866000_59.8.124.26","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/12.5.1046"},{"key":"2025082701541866000_59.8.124.27","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199920040-00006"},{"key":"2025082701541866000_59.8.124.28","doi-asserted-by":"publisher","DOI":"10.1186\/cc3935"},{"key":"2025082701541866000_59.8.124.29","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199701000-00013"},{"key":"2025082701541866000_59.8.124.30","doi-asserted-by":"publisher","DOI":"10.1093\/bjaceaccp\/mkl018"},{"key":"2025082701541866000_59.8.124.31","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(94)90047-7"},{"key":"2025082701541866000_59.8.124.32","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/cpt1978246683","article-title":"Disposition of metformin (N,N-dimethylbiguanide) in man","volume":"24","author":"Sirtori","year":"1978","journal-title":"Clin Pharmacol Ther"},{"key":"2025082701541866000_59.8.124.33","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c857"},{"key":"2025082701541866000_59.8.124.34","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0023200","article-title":"Management of metformin-associated lactic acidosis by continuous renal replacement therapy","volume":"6","author":"Keller","year":"2011","journal-title":"PLoS One"},{"key":"2025082701541866000_59.8.124.35","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e318197eab6"},{"key":"2025082701541866000_59.8.124.36","doi-asserted-by":"publisher","DOI":"10.1081\/CLT-120004407"},{"key":"2025082701541866000_59.8.124.37","first-page":"15","article-title":"Use of two continuous venovenous haemofiltration devices in metformin-associated lactic acidosis","volume":"25","author":"Schopman","year":"2017","journal-title":"Neth J Crit Care"},{"key":"2025082701541866000_59.8.124.38","first-page":"176","article-title":"Continuous venovenous hemofiltration versus continuous venovenous hemodiafiltration in critically ill patients: a retrospective cohort study from a Canadian tertiary centre","volume":"21","author":"AlEnezi","year":"2014","journal-title":"Can Respir J"},{"key":"2025082701541866000_59.8.124.39","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2050-6511-14-22","article-title":"The prognostic value of blood pH and lactate and metformin concentrations in severe metformin-associated lactic acidosis","volume":"14","author":"Kajbaf","year":"2013","journal-title":"BMC Pharmacol Toxicol"},{"key":"2025082701541866000_59.8.124.40","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181a02490"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2021.235608rep","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T08:54:29Z","timestamp":1756284869000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2021.235608rep"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,24]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2021,7,28]]},"published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1136\/dtb.2021.235608rep"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2021.235608rep","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2021,5,24]]}}}