{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:02:36Z","timestamp":1756339356045,"version":"3.44.0"},"reference-count":28,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["DTB"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1136\/dtb.2022.240647rep","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T12:55:19Z","timestamp":1661432119000},"page":"12-15","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Interaction between methadone and clarithromycin as the suspected cause of an opioid toxidrome"],"prefix":"10.1136","volume":"61","author":[{"given":"Blair","family":"Wallace","sequence":"first","affiliation":[{"name":"Intensive Care, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Edwardes","sequence":"additional","affiliation":[{"name":"Pharmacy, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Subbe","sequence":"additional","affiliation":[{"name":"Acute Internal Medicine, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammed","family":"Murtaza","sequence":"additional","affiliation":[{"name":"Endocrinology, Ysbyty Gwynedd, Bangor, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"2025082700412545000_61.1.12.1","unstructured":"Joint Formularly Committee . Methadone interactions in British National Formularly 79. London: BMJ Publishing and the Royal Pharmaceutical Society, 2020."},{"key":"2025082700412545000_61.1.12.2","unstructured":"PubMed . ((\u201cRespiratory Insufficiency\u201d[Mesh]) AND \u201cMacrolides\u201d[Mesh]) AND \u201cMethadone\u201d[Mesh] - Search Results - Pubmed, 2021. Available: https:\/\/pubmed.ncbi.nlm.nih.gov\/?sort=date&term=((%22Respiratory+Insufficiency%22%5BMesh%5D)+AND+%22Macrolides%22%5BMesh%5D)+AND+%22Methadone%22%5BMesh%5D.%20Accessed%20March%206,%202021"},{"key":"2025082700412545000_61.1.12.3","unstructured":"Electronic Medicines Compendium . Methadone 1mg\/ml oral solution sugar free - Summary of Product Characteristics (SmPC) - emc: Martindale Pharma, 2010. Available: https:\/\/www.medicines.org.uk\/emc\/product\/3702\/smpc [Accessed 9 October 2020]."},{"key":"2025082700412545000_61.1.12.4","doi-asserted-by":"publisher","DOI":"10.1080\/J354v16n01_04"},{"key":"2025082700412545000_61.1.12.5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/cpdd.326","article-title":"Current concepts in methadone metabolism and transport","volume":"6","author":"Kharasch","year":"2017","journal-title":"Clin Pharmacol Drug Dev"},{"key":"2025082700412545000_61.1.12.6","unstructured":"Electronic Medicines Compendium . Clarithromycin 500 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc): Aurobindo Pharma, 2014. Available: https:\/\/www.medicines.org.uk\/emc\/product\/7072#gref [Accessed 15th of April 2021]."},{"key":"2025082700412545000_61.1.12.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1521-0391.2009.00005.x"},{"key":"2025082700412545000_61.1.12.8","first-page":"1353","article-title":"Methadone treatment for pain states","volume":"71","author":"Toombs","year":"2005","journal-title":"Am Fam Physician"},{"key":"2025082700412545000_61.1.12.9","unstructured":"Medicines and health product regulatory agency methadone interactive drug analysis profile. Available: https:\/\/info.mhra.gov.uk\/drug-analysis-profiles\/dap.html?drug=.\/UK_EXTERNAL\/NONCOMBINED\/UK_NON_000477049382.zip&agency=MHRA [Accessed 9 october 2020]."},{"key":"2025082700412545000_61.1.12.10","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2006.00289.x"},{"key":"2025082700412545000_61.1.12.11","unstructured":"Preston CL . Methadone Interactions in Stockley\u2019s Drug Interactions. 12th Edition. Pharmaceutical Press, 2020."},{"key":"2025082700412545000_61.1.12.12","first-page":"382","article-title":"Interaction between methadone and ciprofloxacin","volume":"63","author":"Samoy","year":"2010","journal-title":"Can J Hosp Pharm"},{"key":"2025082700412545000_61.1.12.13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00559-06"},{"key":"2025082700412545000_61.1.12.14","doi-asserted-by":"publisher","DOI":"10.1093\/jat\/bkv030"},{"key":"2025082700412545000_61.1.12.15","unstructured":"ed:. Preston CL . Fentanyl and Macrolides - Stockley\u2019s Drug Interactions. 12th Edition. Pharmaceutical Press, 2020."},{"key":"2025082700412545000_61.1.12.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2009.02.230"},{"key":"2025082700412545000_61.1.12.17","article-title":"Fentanyl - clarithromycin interaction","volume":"2012","author":"Cronnolly","year":"2012","journal-title":"Case Rep Child Meml Hosp Chic"},{"key":"2025082700412545000_61.1.12.18","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1985.117"},{"key":"2025082700412545000_61.1.12.19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2131\/jts.44.299","article-title":"Effects of infection of MRSA on the expression and activity of renal cytochrome P450s in mice","volume":"44","author":"Long","year":"2019","journal-title":"J Toxicol Sci"},{"key":"2025082700412545000_61.1.12.20","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.4.277"},{"key":"2025082700412545000_61.1.12.21","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.70"},{"key":"2025082700412545000_61.1.12.22","doi-asserted-by":"publisher","DOI":"10.1080\/13556210020040217"},{"key":"2025082700412545000_61.1.12.23","doi-asserted-by":"crossref","DOI":"10.1345\/aph.1P759","article-title":"Methadone toxicity due to smoking Cessation\u2014A case report on the drug-drug interaction involving cytochrome P450 isoenzyme IA2","volume":"45","author":"Wahawisan","year":"2011","journal-title":"Ann Pharmacother"},{"key":"2025082700412545000_61.1.12.24","doi-asserted-by":"publisher","DOI":"10.1159\/000107104"},{"key":"2025082700412545000_61.1.12.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2005.03.027"},{"key":"2025082700412545000_61.1.12.26","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.200700081"},{"key":"2025082700412545000_61.1.12.27","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21770"},{"key":"2025082700412545000_61.1.12.28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2003.02053.x"}],"container-title":["Drug and Therapeutics Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/dtb.2022.240647rep","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:41:33Z","timestamp":1756280493000},"score":1,"resource":{"primary":{"URL":"https:\/\/dtb.bmj.com\/lookup\/doi\/10.1136\/dtb.2022.240647rep"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,25]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,12,21]]},"published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1136\/dtb.2022.240647rep"],"URL":"https:\/\/doi.org\/10.1136\/dtb.2022.240647rep","relation":{},"ISSN":["0012-6543","1755-5248"],"issn-type":[{"type":"print","value":"0012-6543"},{"type":"electronic","value":"1755-5248"}],"subject":[],"published":{"date-parts":[[2022,8,25]]}}}