{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:30:09Z","timestamp":1789957809268,"version":"4.0.1"},"reference-count":50,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Evid Based Mental Health"],"accepted":{"date-parts":[[2018,3,6]]},"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:p>Dementia with Lewy bodies (DLB) is a common neurodegenerative dementia in older people; however, the clinical features, particularly cognitive fluctuations and rapid eye movement sleep disorder, are often hard to elicit, leading to difficulty in making the diagnosis clinically. Here we examine the literature for the evidence behind imaging modalities that could assist in making the diagnosis. Dopamine transporter (DAT) imaging remains the best modality for differentiation from dementia of Alzheimer\u2019s type with high sensitivity and specificity reported based on pathological diagnoses. <jats:sup>123<\/jats:sup>Iodine-metaiodobenzylguanidine myocardial scintigraphy (MIBG) however is rapidly becoming an alternative imaging modality for the diagnosis of DLB, though studies assessing its accuracy with postmortem verification are still awaited. However, there are suggestions that MIBG may be better in the differentiation of vascular parkinsonism from DLB than DAT scans but may have lower sensitivity for detecting DLB compared with the 80% sensitivity seen in DAT imaging. Structural MRI scans have long been used for the diagnosis of dementia; however, their utility in DLB is limited to revealing the presence of coexisting Alzheimer\u2019s disease. Fluorodeoxyglucose (FDG) PET is an alternative biomarker that can also differentiate Alzheimer\u2019s disease and DLB but lacks the evidence base of both DAT and MIBG scans.<\/jats:p>","DOI":"10.1136\/eb-2017-102848","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T02:20:10Z","timestamp":1522376410000},"page":"61-65","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical imaging in dementia with Lewy bodies"],"prefix":"10.1136","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3809-1545","authenticated-orcid":false,"given":"Ajenthan","family":"Surendranathan","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John Tiernan","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Cambridge, Cambridge, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,3,29]]},"reference":[{"key":"2025082623041556000_21.2.61.1","doi-asserted-by":"publisher","DOI":"10.1038\/42166"},{"key":"2025082623041556000_21.2.61.2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"McKeith","year":"2017","journal-title":"Neurology"},{"key":"2025082623041556000_21.2.61.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2008.00169.x"},{"key":"2025082623041556000_21.2.61.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)95510-8"},{"issue":"Suppl 1","key":"2025082623041556000_21.2.61.5","doi-asserted-by":"crossref","first-page":"S83","DOI":"10.1017\/cjn.2016.2","article-title":"The Prevalence and Incidence of Dementia with Lewy Bodies: a Systematic Review","volume":"43","author":"Hogan","year":"2016","journal-title":"Can J Neurol Sci"},{"key":"2025082623041556000_21.2.61.6","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291713000494"},{"key":"2025082623041556000_21.2.61.7","first-page":"jnnp-2017-316844","article-title":"Accuracy of clinical diagnosis of dementia with Lewy bodies: a systematic review and meta-analysis","volume":"31","author":"Rizzo","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2025082623041556000_21.2.61.8","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"2025082623041556000_21.2.61.9","first-page":"316","article-title":"Improving the clinical detection of lewy body dementia with the lewy body composite risk score","volume":"1","author":"Galvin","year":"2015","journal-title":"Alzheimers Dement"},{"key":"2025082623041556000_21.2.61.10","doi-asserted-by":"crossref","unstructured":"Zhang S , Smailagic N , Hyde C , et al . (11)C-PIB-PET for the early diagnosis of Alzheimer\u2019s disease dementia and other dementias in people with mild cognitive impairment (MCI). Cochrane Database Syst Rev 2014:CD010386.doi:10.1002\/14651858.CD010386.pub2","DOI":"10.1002\/14651858.CD010386.pub2"},{"key":"2025082623041556000_21.2.61.11","doi-asserted-by":"crossref","unstructured":"Smailagic N , VacanteM HC , Martin S , et al . F-FDG-PET for the early diagnosis of Alzheimer\u2019s disease dementia and other dementias in people with mild cognitive impairment (MCI) (Review). 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