{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T22:34:42Z","timestamp":1792881282318,"version":"4.5.0"},"reference-count":50,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Xi\u2019an Science and Technology Plan Project","award":["23YXYJ0180"],"award-info":[{"award-number":["23YXYJ0180"]}]},{"name":"The Innovation Team of Xi\u2019an Medical University","award":["2021TD15"],"award-info":[{"award-number":["2021TD15"]}]},{"name":"Natural Science Basic Research Plan","award":["2022JQ-980"],"award-info":[{"award-number":["2022JQ-980"]}]},{"name":"Fund Project of the First Affiliated Hospital of Xi\u2019an Medical College","award":["XYFYPT-2023-06"],"award-info":[{"award-number":["XYFYPT-2023-06"]}]},{"name":"Fund Project of the First Affiliated Hospital of Xi\u2019an Medical College","award":["XYFYPT-2023-07"],"award-info":[{"award-number":["XYFYPT-2023-07"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["egastro"],"accepted":{"date-parts":[[2025,6,6]]},"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>To investigate the correlation between infection of <jats:italic>Helicobacter pylori (H. pylori<\/jats:italic>) and the risk of reflux oesophagitis (RE) occurrence or recurrence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Literature was retrieved from PubMed, Embase, Web of Science and Cochrane Library databases, and the search period ranged from the time of database establishment to December 2024. Prospective cohort studies and randomised controlled trials were included for data analysis to assess the association of infection of <jats:italic>H. pylori<\/jats:italic> with the risk of RE occurrence and recurrence, and subgroup analyses were performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall risk of RE in the <jats:italic>H. pylori-<\/jats:italic>eradicated group was significantly higher than that in the placebo group (p&lt;0.01). The analysis failed to detect a statistically significant difference in RE risk between the <jats:italic>H. pylori-<\/jats:italic>eradicated group and placebo group among different age groups, regions and disease types. The risk of RE significantly increased after eradication of <jats:italic>H. pylori<\/jats:italic> for &gt;1 year (p&lt;0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Infection of <jats:italic>H. pylori<\/jats:italic> in different age groups, regions and diseases may lead to the occurrence or recurrence of RE after receiving <jats:italic>H. pylori<\/jats:italic> eradication treatment. This correlation increased as the follow-up period extended. Although receiving <jats:italic>H. pylori<\/jats:italic> eradication treatment may increase the risk of RE occurrence or recurrence, doctors should take into consideration the individual situation of the patient to determine whether eradication treatment should be administered concomitantly or postponed during clinical treatment decision making.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration number<\/jats:title>\n                  <jats:p>CRD 42024529321.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/egastro-2024-100121","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T14:30:21Z","timestamp":1750948221000},"page":"e100121","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Association between infection of <i>Helicobacter pylori<\/i> and the risk of reflux oesophagitis occurrence or recurrence: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"3","author":[{"given":"Anna","family":"Li","sequence":"first","affiliation":[{"name":"Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"},{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"},{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunping","family":"Chen","sequence":"additional","affiliation":[{"name":"Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"},{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Quan","sequence":"additional","affiliation":[{"name":"Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"},{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yin","sequence":"additional","affiliation":[{"name":"Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"},{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manli","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3945-3387","authenticated-orcid":false,"given":"Mingxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, The First Affiliated Hospital of Xi\u2019an Medical University, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"2025081719112025000_3.2.e100121.1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1998.tb00540.x"},{"key":"2025081719112025000_3.2.e100121.2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.326.7392.737"},{"key":"2025081719112025000_3.2.e100121.3","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/1751-2980.13028","article-title":"Chinese expert consensus on gastroesophageal reflux disease in 2020","volume":"22","author":"Xiao","year":"2021","journal-title":"J Dig Dis"},{"key":"2025081719112025000_3.2.e100121.4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01189.x"},{"key":"2025081719112025000_3.2.e100121.5","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2011.17.3.267"},{"key":"2025081719112025000_3.2.e100121.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00394.x"},{"key":"2025081719112025000_3.2.e100121.7","doi-asserted-by":"crossref","first-page":"S","DOI":"10.1016\/S0016-5085(23)03777-0","article-title":"EP56 STUDY ON THE CORRELATION BETWEEN THE SEVERITY OF REFLUX ESOPHAGITIS AND HELICOBACTER PYLORI INFECTION","volume":"164","author":"Du","year":"2023","journal-title":"Gastroenterology"},{"key":"2025081719112025000_3.2.e100121.8","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s005350200031","article-title":"Helicobacter pylori infection and hiatal hernia do not affect acid reflux and esophageal motility in patients with gastro-esophageal reflux","volume":"37","author":"Awad","year":"2002","journal-title":"J Gastroenterol"},{"key":"2025081719112025000_3.2.e100121.9","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"2025081719112025000_3.2.e100121.10","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.j4008","article-title":"AMSTAR 2: a critical appraisal tool for systematic reviews that include randomised or non-randomised studies of healthcare interventions, or both","volume":"358","author":"Shea","year":"2017","journal-title":"BMJ"},{"key":"2025081719112025000_3.2.e100121.11","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"2025081719112025000_3.2.e100121.12","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"2025081719112025000_3.2.e100121.13","doi-asserted-by":"publisher","DOI":"10.5009\/gnl.2011.5.4.437"},{"key":"2025081719112025000_3.2.e100121.14","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2010.251"},{"key":"2025081719112025000_3.2.e100121.15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.3390\/medicina46070065","article-title":"De novo erosive esophagitis in duodenal ulcer patients related to pre-existing reflux symptoms, smoking, and patient age, but not to Helicobacter pylori eradication: a one-year follow-up study","volume":"46","author":"Jonaitis","year":"2010","journal-title":"Medicina (Kaunas)"},{"key":"2025081719112025000_3.2.e100121.16","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1440-1746.2008.05606.x","article-title":"Helicobacter pylori eradication may induce de novo, but transient and mild, reflux esophagitis: Prospective endoscopic evaluation","volume":"24","author":"Take","year":"2009","journal-title":"J Gastroenterol Hepatol"},{"key":"2025081719112025000_3.2.e100121.17","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3390\/medicina44030027","article-title":"Gastroesophageal reflux disease after Helicobacter pylori eradication in gastric ulcer patients: a one-year follow-up study","volume":"44","author":"Jonaitis","year":"2008","journal-title":"Medicina (Kaunas)"},{"key":"2025081719112025000_3.2.e100121.18","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10620-006-3167-2","article-title":"Factors associated with the development of reflux esophagitis after Helicobacter pylori eradication","volume":"51","author":"Tsukada","year":"2006","journal-title":"Dig Dis Sci"},{"key":"2025081719112025000_3.2.e100121.19","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-005-1685-x"},{"key":"2025081719112025000_3.2.e100121.20","doi-asserted-by":"publisher","DOI":"10.1542\/peds.113.1.54"},{"key":"2025081719112025000_3.2.e100121.21","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200404000-00001"},{"key":"2025081719112025000_3.2.e100121.22","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.11.1543"},{"key":"2025081719112025000_3.2.e100121.23","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1590-8658(02)80125-6","article-title":"Influence of Helicobacter pylori infection on severity of oesophagitis and response to therapy in the elderly","volume":"34","author":"Pilotto","year":"2002","journal-title":"Dig Liver Dis"},{"key":"2025081719112025000_3.2.e100121.24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1046\/j.1365-2036.2000.014s1161.x","article-title":"The incidence of reflux oesophagitis after cure of Helicobacter pylori in a Japanese population","volume":"14 Suppl 1","author":"Murai","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"2025081719112025000_3.2.e100121.25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00758.x"},{"key":"2025081719112025000_3.2.e100121.26","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70024-6"},{"key":"2025081719112025000_3.2.e100121.27","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41366-019-0391-3","article-title":"Potential roles of Helicobacter pylori treatment, body mass index and waist circumference in the causation of erosive esophagitis: a randomized clinical trial (HEROES-GERD)","volume":"44","author":"Mazzoleni","year":"2020","journal-title":"Int J Obes"},{"key":"2025081719112025000_3.2.e100121.28","doi-asserted-by":"crossref","first-page":"995","DOI":"10.4103\/0366-6999.155049","article-title":"Effect of Helicobacter pylori eradication on reflux esophagitis therapy: a multi-center randomized control study","volume":"128","author":"Xue","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"2025081719112025000_3.2.e100121.29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1590\/S0004-28032012000100010","article-title":"Helicobacter pylori eradication does not influence gastroesophageal reflux disease: a prospective, parallel, randomized, open-label, controlled trial","volume":"49","author":"Rodrigues","year":"2012","journal-title":"Arq Gastroenterol"},{"key":"2025081719112025000_3.2.e100121.30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1365-2036.2006.02964.x","article-title":"Patterns of gastritis and the effect of eradicating Helicobacter pylori on gastro-oesophageal reflux disease in Western patients with non-ulcer dyspepsia","volume":"24","author":"Vakil","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"2025081719112025000_3.2.e100121.31","doi-asserted-by":"publisher","DOI":"10.1159\/000090955"},{"key":"2025081719112025000_3.2.e100121.32","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1111\/j.1365-2036.2005.02461.x","article-title":"Helicobacter pylori eradication does not cause reflux oesophagitis in functional dyspeptic patients: a randomized, investigator-blinded, placebo-controlled trial","volume":"21","author":"Ott","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"2025081719112025000_3.2.e100121.33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.012641"},{"key":"2025081719112025000_3.2.e100121.34","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01285.x"},{"key":"2025081719112025000_3.2.e100121.35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07116.x"},{"key":"2025081719112025000_3.2.e100121.36","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04894-7"},{"key":"2025081719112025000_3.2.e100121.37","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010616710501"},{"key":"2025081719112025000_3.2.e100121.38","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.29332"},{"key":"2025081719112025000_3.2.e100121.39","first-page":"914","article-title":"Is Helicobacter pylori eradication associated with gastroesophageal reflux disease?","volume":"95","author":"Fallone","year":"2000","journal-title":"J Gastroenterol"},{"key":"2025081719112025000_3.2.e100121.40","doi-asserted-by":"publisher","DOI":"10.1080\/003655200451135"},{"key":"2025081719112025000_3.2.e100121.41","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-5378.2000.00031.x"},{"key":"2025081719112025000_3.2.e100121.42","first-page":"1023","article-title":"Helicobacter pylori and gastroesophageal reflux disease: friends or foes?","volume":"46","author":"Gisbert","year":"1999","journal-title":"Hepatogastroenterology"},{"key":"2025081719112025000_3.2.e100121.43","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/00365521.2019.1701071","article-title":"Localization of Helicobacter pylori gastritis and the relation of existing histopathological features with reflux esophagitis","volume":"55","author":"Yalaki","year":"2020","journal-title":"Scand J Gastroenterol"},{"key":"2025081719112025000_3.2.e100121.44","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2036.2005.02607.x","article-title":"Review article: Helicobacter pylori and gastro-oesophageal reflux disease","volume":"22 Suppl 1","author":"Delaney","year":"2005","journal-title":"Aliment Pharmacol Ther"},{"key":"2025081719112025000_3.2.e100121.45","doi-asserted-by":"crossref","DOI":"10.4081\/pr.2013.e3","article-title":"Helicobacter pylori infection has no impact on manometric and pH-metric findings in adolescents and young adults with gastroesophageal reflux and antral gastritis: eradication results to no significant clinical improvement","volume":"5","author":"Xinias","year":"2013","journal-title":"Pediatr Rep"},{"key":"2025081719112025000_3.2.e100121.46","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0000000000000429"},{"key":"2025081719112025000_3.2.e100121.47","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7819-12-375","article-title":"Does a relationship still exist between gastroesophageal reflux and Helicobacter pylori in patients with reflux symptoms?","volume":"12","author":"Grande","year":"2014","journal-title":"World J Surg Oncol"},{"key":"2025081719112025000_3.2.e100121.48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/jcm9093007","article-title":"Endoscopic Reflux Esophagitis and Reflux-Related Symptoms after Helicobacter pylori Eradication Therapy: Meta-Analysis","volume":"9","author":"Sugimoto","year":"2020","journal-title":"J Clin Med"},{"key":"2025081719112025000_3.2.e100121.49","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01346.x"},{"key":"2025081719112025000_3.2.e100121.50","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10388-018-0637-5","article-title":"Interactions between Helicobacter pylori and gastroesophageal reflux disease","volume":"16","author":"Yucel","year":"2019","journal-title":"Esophagus"}],"container-title":["eGastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/egastro-2024-100121","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T02:15:49Z","timestamp":1755483349000},"score":1,"resource":{"primary":{"URL":"http:\/\/egastroenterology.bmj.com\/lookup\/doi\/10.1136\/egastro-2024-100121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,6,26]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/egastro-2024-100121"],"URL":"https:\/\/doi.org\/10.1136\/egastro-2024-100121","relation":{},"ISSN":["2766-0125","2976-7296"],"issn-type":[{"value":"2766-0125","type":"print"},{"value":"2976-7296","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]}}}