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Chronic liver disease and cirrhosis have also been linked with periodontal disease, an association with complex underlying mechanisms, and with potential prognostic implications. Multiple factors can explain this relevant association, including nutritional factors, alcohol consumption, disruption of the oral-gut-liver axis and associated dysbiosis. Additionally, patients with liver disease have been observed to exhibit poorer oral hygiene practices compared with the general population, potentially predisposing them to the development of periodontal disease. Therefore, it is recommended that all patients with liver disease undergo screening and subsequent treatment for periodontal disease. Treatment of periodontal disease in patients with cirrhosis may help reduce liver-derived inflammatory damage, with recent research indicating a potential benefit in terms of reduced mortality. However, further studies on periodontal disease treatment in patients with liver disease are still warranted to determine optimal management strategies. This narrative review describes current concepts on the association between periodontal disease and chronic liver disease.<\/jats:p>","DOI":"10.1136\/egastro-2024-100140","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T11:20:14Z","timestamp":1740482414000},"page":"e100140","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Periodontal disease and cirrhosis: current concepts and future prospects"],"prefix":"10.1136","volume":"3","author":[{"given":"David","family":"Hudson","sequence":"first","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Ayares","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Taboun","sequence":"additional","affiliation":[{"name":"Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gurpreet","family":"Malhi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Idalsoaga","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada"},{"name":"Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rokhsana","family":"Mortuza","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine, Schulich School of Medicine, Western University & London Health Sciences Centre, London, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maite","family":"Souyet","sequence":"additional","affiliation":[{"name":"Escuela de Odontolog\u00eda, Facultad de Medicina y Ciencias de la Salud, Universidad Mayor, Santiago, Chile"},{"name":"Escuela de Odontolog\u00eda, Facultad de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ramirez-Cadiz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Antonio","family":"D\u00edaz","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"MASLD Research Center, Division of Gastroenterology and Hepatology, University of California San Diego, San Diego, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Arrese","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8561-396X","authenticated-orcid":false,"given":"Juan Pablo","family":"Arab","sequence":"additional","affiliation":[{"name":"Departamento de Gastroenterologia, Escuela de Medicina, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"},{"name":"Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"2025081719083079000_3.1.e100140.1","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41575-023-00822-y","article-title":"The intersection between alcohol-related liver disease and nonalcoholic fatty liver disease","volume":"20","author":"D\u00edaz","year":"2023","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2025081719083079000_3.1.e100140.2","doi-asserted-by":"crossref","unstructured":"Irie K , Ekuni D , Tomofuji T , et al . 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