{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:15:20Z","timestamp":1793412920204,"version":"4.5.0"},"reference-count":18,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Emerg Med J"],"accepted":{"date-parts":[[2013,1,6]]},"published-print":{"date-parts":[[2014,3]]},"abstract":"<jats:sec><jats:title>Study objective<\/jats:title><jats:p>The objective of this study was to determine the analgesic efficacy and safety of intravenous, single-dose paracetamol versus dexketoprofen versus morphine in patients presenting with mechanical low back pain (LBP) to the emergency department (ED).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This randomised double-blind study compared the efficacy of intravenous 1\u2005gm paracetamol, 50\u2005mg dexketoprofen and 0.1\u2005mg\/kg morphine in patients with acute mechanical LBP. Visual analogue scale (VAS) was used for pain measurement at baseline, after 15 and after 30\u2005min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 874 patients were eligible for the study, and 137 of them were included in the final analysis: 46 patients from the paracetamol group, 46 patients in the dexketoprofen group and 45 patients in the morphine group. The mean age of study subjects was 31.5\u00b19.5\u2005years, and 60.6% (n=83) of them were men. The median reduction in VAS score at the 30th minute for the paracetamol group was 65\u2005mm (95% CI 58 to 72), 67\u2005mm (95% CI 60 to 73) for the morphine group and 58\u2005mm (95% CI 50 to 64) for the dexketoprophen group. Although morphine was not superior to paracetamol at 30\u2005min (difference: 3.8\u00b14.9 (95% CI \u22126 to 14), the difference between morphine and dexketoprofen in reducing pain was 11.2\u00b14.7 (95% CI 2 to 21). At least one adverse effect occurred in 8.7% (n=4) of the cases in the paracetamol group, 15.5% (n=7) of the morphine group, and 8.7% (n=4) of the dexketoprophen group (p=0.482).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Intravenous paracetamol, dexketoprofen and morphine are not superior to each other for the treatment of mechanical LBP in ED.<\/jats:p><\/jats:sec>","DOI":"10.1136\/emermed-2012-201670","type":"journal-article","created":{"date-parts":[[2013,2,14]],"date-time":"2013-02-14T02:22:42Z","timestamp":1360808562000},"page":"177-181","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Intravenous paracetamol versus dexketoprofen versus morphine in acute mechanical low back pain in the emergency department: a randomised double-blind controlled trial"],"prefix":"10.1136","volume":"31","clinical-trial-number":[{"clinical-trial-number":"nct01422291","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Cenker","family":"Eken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Serinken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayri","family":"Elicabuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"Uyanik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Erdal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2013,2,13]]},"reference":[{"key":"2024052700142051000_31.3.177.1","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e3181d952a5"},{"key":"2024052700142051000_31.3.177.2","doi-asserted-by":"publisher","DOI":"10.1136\/emj.2010.104687"},{"key":"2024052700142051000_31.3.177.3","doi-asserted-by":"publisher","DOI":"10.1053\/ajem.2000.7314"},{"key":"2024052700142051000_31.3.177.4","doi-asserted-by":"crossref","unstructured":"Holdgate A Pollock T . 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