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Angiotensin II (Ang-2) has been previously used as a vasopressor to combat shock; the feasibility of its clinical use has been reinvigorated after approval of a human synthetic formulation of the medication by the US Food and Drug Administration in 2017 and the European Medicines Agency in 2019. A thorough literature search was completed, and in this review, we discuss the discovery and development of Ang-2, its complex mechanisms of vasoconstriction, its potential adverse effects and its potential role in clinical practice for emergency physicians.<\/jats:p>","DOI":"10.1136\/emermed-2019-209062","type":"journal-article","created":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T22:16:53Z","timestamp":1582150613000},"page":"717-721","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Angiotensin II for the emergency physician"],"prefix":"10.1136","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-0412","authenticated-orcid":false,"given":"Marianne C","family":"Wallis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan H","family":"Chow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael E","family":"Winters","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5319-0475","authenticated-orcid":false,"given":"Michael T","family":"McCurdy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"key":"2024102605501097000_37.11.717.1","doi-asserted-by":"crossref","unstructured":"Chow JH , Abuelkasem E , Sankova S , et al . 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