{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T04:06:13Z","timestamp":1750997173568,"version":"3.41.0"},"reference-count":6,"publisher":"BMJ","issue":"6","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Emerg Med J"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:p>Prehn\u2019s sign describes the eradication of testicular pain on lifting the scrotum and has been proposed as a method to differentiate causes of acute testicular pain. A short systematic review was conducted to evaluate the question: in patients presenting with acute unilateral testicular pain, is a negative Prehn\u2019s sign an accurate sign for diagnosis of testicular torsion (TT)?<\/jats:p>\n<jats:p>Medline, Embase and Cochrane databases were searched using the OVID interface from inception to 26 February 2025. Following the removal of duplicates, the search strategy yielded a total of 11 papers. Study information, participant group, relevant outcomes and study weaknesses were extracted from each article.<\/jats:p>\n<jats:p>Four studies addressed the three-part question. The only study that had the full text available for review found that 33% of patients with TT had a positive Prehn\u2019s sign, which equated to an OR of 5.941 (95% CI 1.432 to 24.658). Of the three remaining retrospective cohort studies, Prehn\u2019s sign was reported to be positive in 10.5%, 37.5% and 100% of patients with TT, respectively. Therefore, the negativity of Prehn\u2019s sign ranged from 0% to 89.5% in patients with TT.<\/jats:p>\n<jats:p>The clinical bottom line is that Prehn\u2019s sign is insufficiently sensitive to rule out TT; however, its negativity increases the likelihood of a TT diagnosis.<\/jats:p>","DOI":"10.1136\/emermed-2025-214935","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T17:20:11Z","timestamp":1744132811000},"page":"411-412","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["In emergency settings, can a negative Prehn\u2019s sign be used to aid diagnosis of testicular torsion?"],"prefix":"10.1136","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1114-5926","authenticated-orcid":false,"given":"Lauren Grace","family":"Edwards","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua William","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Craig","family":"Ferguson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2025,4,8]]},"reference":[{"key":"2025062400001791000_42.6.411.1","unstructured":"Velasquez J , Boniface MP , Mohseni M . Acute scrotum pain. In: StatPearls. Treasure (FL): StatPearls Publishing LLC, 2022."},{"key":"2025062400001791000_42.6.411.2","doi-asserted-by":"publisher","DOI":"10.5001\/omj.2018.10"},{"key":"2025062400001791000_42.6.411.3","first-page":"380","article-title":"Clinical study of testicular torsion in the Kyushu District - Kyushu Cooperative Urological Research","volume":"64","author":"Hatano","year":"2002","journal-title":"Nishinihon J Urol"},{"key":"2025062400001791000_42.6.411.4","first-page":"723","article-title":"Clinical studies on acute scrotum-focusing on torsion of the spermatic cord","volume":"42","author":"Nishimura","year":"1996","journal-title":"Hinyokika Kiyo"},{"key":"2025062400001791000_42.6.411.5","first-page":"520","article-title":"Clinical characteristics of acute scrotum: analysis of 316 cases","volume":"16","author":"Chen","year":"2010","journal-title":"Zhonghua Nan Ke Xue"},{"key":"2025062400001791000_42.6.411.6","doi-asserted-by":"publisher","DOI":"10.2147\/OAEM.S236767"}],"container-title":["Emergency Medicine Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/emermed-2025-214935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T11:49:05Z","timestamp":1750938545000},"score":1,"resource":{"primary":{"URL":"https:\/\/emj.bmj.com\/lookup\/doi\/10.1136\/emermed-2025-214935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,8]]},"references-count":6,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,5,22]]},"published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1136\/emermed-2025-214935"],"URL":"https:\/\/doi.org\/10.1136\/emermed-2025-214935","relation":{},"ISSN":["1472-0205","1472-0213"],"issn-type":[{"type":"print","value":"1472-0205"},{"type":"electronic","value":"1472-0213"}],"subject":[],"published":{"date-parts":[[2025,4,8]]}}}