{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T15:28:11Z","timestamp":1764602891785,"version":"3.44.0"},"reference-count":12,"publisher":"BMJ","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Accid Emerg Med"],"published-print":{"date-parts":[[1996,5]]},"abstract":"<jats:p>OBJECTIVE--To assess the analgesic effects of a topical non-steroidal anti-inflammatory agent, flurbiprofen 0.03%, during healing after superficial corneal injuries. METHODS--401 patients treated for corneal abrasion in a five month period were randomly allocated to one of four treatment groups: polyvinyl alcohol alone (control), homatropine 2%, flurbiprofen 0.03%, or homatropine 2% followed by flurbiprofen 0.03%. Treatments were given for 48 h. Ocular pain was recorded on a visual analogue scale by the patients over the first 24 h, and use of oral analgesics was also recorded. Usable responses were received from 224 patients (55.8%). RESULTS--Patients treated with flurbiprofen had significantly lower pain scores for the 24 h duration of the study than controls (P &lt; 0.05). CONCLUSIONS--Flurbiprofen eye drops provide more effective pain relief than traditional treatments for superficial corneal injuries.<\/jats:p>","DOI":"10.1136\/emj.13.3.186","type":"journal-article","created":{"date-parts":[[2008,10,4]],"date-time":"2008-10-04T14:35:54Z","timestamp":1223130954000},"page":"186-188","source":"Crossref","is-referenced-by-count":23,"title":["Topical analgesia for superficial corneal injuries."],"prefix":"10.1136","volume":"13","author":[{"given":"A K","family":"Brahma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Shah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V F","family":"Hillier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"McLeod","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Sabala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Marsden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1996,5,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/014107688307600408","article-title":"Analysis of all new cases seen in a busy regional centre ophthalmic casualty department during a 24 week period","volume":"73","author":"Vernon, S.","year":"1983","unstructured":"Vernon S. Analysis of all new cases seen in a busy regional centre ophthalmic casualty department during a 24 week period. J R Soc Med 1983;73:279-82.","journal-title":"J R Soc Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.iy.02.040184.002003","article-title":"The role of arachidonic acid oxygenation products in pain and inflammation","volume":"2","author":"Davies, P.; Bailey, P.J.; Goldeberg, M.M.; Ford-Hutchinson, A.W.","year":"1984","unstructured":"Davies P, Bailey PJ, Goldeberg MM, Ford-Hutchinson AW. The role of arachidonic acid oxygenation products in pain and inflammation. Annu Rev Immunol 1984;2:335-57.","journal-title":"Annu Rev Immunol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0002-9343(86)90083-5","article-title":"Use of diclofenac in analgesia","volume":"80","author":"Kantor, T.G.","year":"1986","unstructured":"Kantor TG. Use of diclofenac in analgesia. Am J Med 1986;80(suppl 4B):64-9.","journal-title":"Am J Med"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/newbio231232a0","article-title":"Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs","volume":"231","author":"Vane, JR","year":"1971","unstructured":"Vane JR. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature New Biol 1971;231:232-9.","journal-title":"Nature New Biol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3959(82)90092-6","article-title":"Density and organisation of free nerve endings in the corneal epithelium of rabbits","volume":"14","author":"Rozsa, A.J.; Beuerman, R.W.","year":"1982","unstructured":"Rozsa AJ, Beuerman RW. Density and organisation of free nerve endings in the corneal epithelium of rabbits. 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NewYork: Elsevier, 1985: 107-16."},{"issue":"18","key":"ref_8","first-page":"312","article-title":"Decrease in normal human corneal sensitivity with topical diclofenac sodium","volume":"1","author":"J, Lee M.; P, McDonnel","year":"1994","unstructured":"Szereny K, Sorken K, Garbus J, Lee M, McDonnel P. Decrease in normal human corneal sensitivity with topical diclofenac sodium. Am J Ophthalmol 1994;1 18:312-5.","journal-title":"Am J Ophthalmol"},{"issue":"893","key":"ref_9","article-title":"Voltaren for treatment of discomfort after excimer ablation [ARVO abstracts]","volume":"1993","author":"Herschel, M.K.; McDonald, M.B.; Ahmed, S.; Klyce, R.J.; Vamell, R.J.; Thompson, H.W.","unstructured":"Herschel MK, McDonald MB, Ahmed S, Klyce RJ, Vamell RJ, Thompson HW. Voltaren for treatment of discomfort after excimer ablation [ARVO abstracts]. 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Invest Ophthalmol Vis Sci 1981;20: 688-91.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/archopht.1990.01070060125062","article-title":"Topical nonsteroidal agents and corneal wound healing","volume":"108","author":"Hersh, A.; Rice, B.A.; Baer, J.C.; Wells, P.A.; Lynch, E.; McGuigan, L.J.B.","year":"1990","unstructured":"Hersh A, Rice BA, Baer JC, Wells PA, Lynch E, McGuigan LJB, et al. Topical nonsteroidal agents and corneal wound healing. 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