{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:31:55Z","timestamp":1757619115291,"version":"3.44.0"},"reference-count":14,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2013,7,24]]},"published-print":{"date-parts":[[2014,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This pilot study was undertaken to assess the validity and effectiveness of near-patient coeliac immunological testing, compared to standard laboratory immunological techniques, used in the context of dietician-led coeliac disease follow-up clinics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>The study was designed in two phases, each assessing the near-patient test and standard laboratory immunological techniques. Phase 1 analysed stored serum samples; Phase 2 analysed whole blood from patients attending the dietician-led coeliac disease clinics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Patients were recruited from New Cross Hospital, Wolverhampton (n=50), and Imperial College London (n=30), between March 2010 and February 2011.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>Those with a diagnosis of coeliac disease for greater than 12\u2005months attending dietician-led coeliac disease clinics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>In addition to whole blood taken for routine analysis, patients required a capillary finger-prick blood sample.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measure<\/jats:title>\n                  <jats:p>To determine if the whole blood and serum near-patient test results were in correlation with outcomes of standard laboratory evaluation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Phase 1 demonstrated that the near-patient serum test had a sensitivity of 93.5% (95% CI 0.79% to 0.98%), specificity of 94.9% (0.83% to 0.99%), when compared to standard laboratory ELISA. Phase 2, involving patients whole blood, had a sensitivity of 77.8% (0.45% to 0.93%), and specificity of 100% (0.94% to 1%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This pilot study has demonstrated that there appears to be a role for near-patient testing in coeliac disease, but further studies are recommended.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/flgastro-2013-100342","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T00:41:55Z","timestamp":1378255315000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["The role of near-patient coeliac serology testing in the follow-up of patients with coeliac disease"],"prefix":"10.1136","volume":"5","author":[{"given":"D A","family":"George","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L L","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Rattehalli","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Lovatt","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, New Cross Hospital, Wolverhampton, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Perry","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, New Cross Hospital, Wolverhampton, 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