{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T21:30:34Z","timestamp":1778707834449,"version":"3.51.4"},"reference-count":11,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2015,5,19]]},"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:p>Colonic segments are being used as pedicled grafts in neovaginoplasty, a surgical procedure to (re)construct a (neo)vagina. A disadvantage of using colonic grafts is the potential occurrence of neovaginal complications due to diversion from the faecal stream. Here, we report a case of severe, refractory diversion colitis of the sigmoid neovagina, so-called \u2018diversion neovaginitis\u2019, in a 42-year-old woman with complete androgen insensitivity syndrome. Neovaginal biopsy specimens showed colonic-type mucosa with strong increase of lymphoplasmacellular infiltrate in the lamina propria, ulceration with fibrinoid deposition and some crypt irregularity. Endoscopy showed erythematous mucosa, superficial ulceration, mucus discharge and multiple pseudopolyp-like lesions. Local application of mesalazine foam enemas and sodium butyrate enemas initially gave symptom relief. However, this was a temporary effect, ultimately necessitating removal of the neovaginal construct. It is important that all patients are informed about neovaginal bowel complications, for example, diversion neovaginitis. Regular medical and endoscopic follow-up appears recommendable.<\/jats:p>","DOI":"10.1136\/flgastro-2015-100602","type":"journal-article","created":{"date-parts":[[2015,6,4]],"date-time":"2015-06-04T23:10:30Z","timestamp":1433459430000},"page":"227-230","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Refractory diversion neovaginitis in a sigmoid-colon-derived neovagina: clinical and histopathological considerations"],"prefix":"10.1136","volume":"7","author":[{"given":"WB","family":"van der Sluis","sequence":"first","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Bouman","sequence":"additional","affiliation":[{"name":"Department of Plastic, Reconstructive and Hand Surgery, VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Center of Expertise on Gender Dysphoria, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"WJHJ","family":"Meijerink","sequence":"additional","affiliation":[{"name":"Center of Expertise on Gender Dysphoria, VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Gastro-Intestinal Surgery and Advanced Laparoscopy, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"EA","family":"Neefjes-Borst","sequence":"additional","affiliation":[{"name":"Department of Pathology, VU University Medical Center, Amsterdam, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"AA","family":"van Bodegraven","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, VU University Medical Center, Amsterdam, The Netherlands"},{"name":"Department of Gastroenterology, ORBIS Medical Center, Sittard-Geleen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,6,4]]},"reference":[{"key":"2025090709240143000_7.3.227.1","doi-asserted-by":"publisher","DOI":"10.1111\/jsm.12538"},{"key":"2025090709240143000_7.3.227.2","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/00006534-199504001-00012","article-title":"Unfavorable long-term results of rectosigmoid neocolpopoiesis","volume":"95","author":"Hage","year":"1995","journal-title":"Plast Reconstr Surg"},{"key":"2025090709240143000_7.3.227.3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/0016-5085(81)90003-2","article-title":"Proctitis and colitis following diversion of the fecal stream","volume":"80","author":"Glotzer","year":"1981","journal-title":"Gastroenterology"},{"key":"2025090709240143000_7.3.227.4","doi-asserted-by":"publisher","DOI":"10.1007\/BF02909487"},{"key":"2025090709240143000_7.3.227.5","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/0046-8177(93)90134-3","article-title":"The occurrence of diversion colitis in patients with a sigmoid neovagina","volume":"24","author":"Toolenaar","year":"1993","journal-title":"Hum Pathol"},{"key":"2025090709240143000_7.3.227.6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2001.02180.x"},{"key":"2025090709240143000_7.3.227.7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2004.00653.x"},{"key":"2025090709240143000_7.3.227.8","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21108"},{"key":"2025090709240143000_7.3.227.9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.32.9.1020"},{"key":"2025090709240143000_7.3.227.10","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1999.00624.x"},{"key":"2025090709240143000_7.3.227.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-6109.2011.02494.x"}],"container-title":["Frontline Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/flgastro-2015-100602","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:24:08Z","timestamp":1757262248000},"score":1,"resource":{"primary":{"URL":"https:\/\/fg.bmj.com\/lookup\/doi\/10.1136\/flgastro-2015-100602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,4]]},"references-count":11,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2016,6,3]]},"published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1136\/flgastro-2015-100602"],"URL":"https:\/\/doi.org\/10.1136\/flgastro-2015-100602","relation":{},"ISSN":["2041-4137","2041-4145"],"issn-type":[{"value":"2041-4137","type":"print"},{"value":"2041-4145","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,4]]}}}