{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:54:22Z","timestamp":1793426062425,"version":"4.5.0"},"reference-count":25,"publisher":"BMJ","issue":"2","funder":[{"DOI":"10.13039\/100006775","name":"GE Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006775","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2017,5,6]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In 2012, the National Institute for Health and Care Excellence (NICE) assessed guidance (DG7) on the use of tauroselcholic (<jats:sup>75<\/jats:sup>selenium) acid (also known as SeHCAT) for the investigation of diarrhoea due to bile acid malabsorption (BAM) in patients with IBS-D and in patients with Crohn\u2019s disease who have not had an ileal resection. NICE concluded that tauroselcholic (<jats:sup>75<\/jats:sup>selenium) acid was recommended for use in research only. NICE will be reviewing the decision to update the guidance for tauroselcholic (<jats:sup>75<\/jats:sup>selenium) acid, for these populations, in March 2017.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>Our aim is to summarise advances in BAM, also known as bile acid diarrhoea (BAD), and encourage clinicians to re-evaluate their understanding of this disorder.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Approach<\/jats:title>\n                  <jats:p>We review the prevalence, diagnosis and treatment of BAD\/BAM. We describe the new evidence available since the original NICE review in 2012, and discuss the economic issues associated with failure to diagnose or to treat BAD\/BAM accurately.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Evidence update<\/jats:title>\n                  <jats:p>There is new and compelling evidence available since DG7, which shows that tauroselcholic (<jats:sup>75<\/jats:sup>selenium) acid scanning is a powerful tool in the diagnosis of BAD\/BAM. We summarise published prevalence data (approximately 1% prevalence in the UK, as suggested by clinical practice diagnosis rates), and highlight that the true prevalence of BAD\/BAM could be far greater than this.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We present evidence that challenges current opinion about this disorder, and we commend both clinicians and health technology assessment (HTA) agencies for being open to arguments and new evidence in any future HTAs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/flgastro-2017-100808","type":"journal-article","created":{"date-parts":[[2017,6,29]],"date-time":"2017-06-29T20:40:47Z","timestamp":1498768847000},"page":"92-97","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Challenging current views on bile acid diarrhoea and malabsorption"],"prefix":"10.1136","volume":"9","author":[{"given":"Matthew","family":"Kurien","sequence":"first","affiliation":[{"name":"Academic Unit of Gastroenterology, Department of Infection, Immunity and Cardiovascular Sciences, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Thurgar","sequence":"additional","affiliation":[{"name":"BresMed Health Solutions, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Davies","sequence":"additional","affiliation":[{"name":"BresMed Health Solutions, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron","family":"Akehurst","sequence":"additional","affiliation":[{"name":"BresMed Health Solutions, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jervoise","family":"Andreyev","sequence":"additional","affiliation":[{"name":"The GI and Nutrition Team, The Royal Marsden NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,6,29]]},"reference":[{"key":"2025090709093584000_9.2.92.1","doi-asserted-by":"publisher","DOI":"10.1177\/1756283X10377126"},{"key":"2025090709093584000_9.2.92.2","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12466"},{"key":"2025090709093584000_9.2.92.3","unstructured":"Brand SJ SW . Textbook of Gastroenterology. Philadelphia: JB Lippincott Company, 1995:25\u201371."},{"key":"2025090709093584000_9.2.92.4","first-page":"2881","article-title":"Outcomes from treating bile acid malabsorption using a multidisciplinary approach","volume":"23","author":"Gupta","year":"2015","journal-title":"Support Care Cancer"},{"key":"2025090709093584000_9.2.92.5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1111\/codi.12932","article-title":"Are bile acid malabsorption and bile acid diarrhoea important causes of loose stool complicating Cancer therapy?","volume":"17","author":"Phillips","year":"2015","journal-title":"Colorectal Dis"},{"key":"2025090709093584000_9.2.92.6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/MNM.0b013e32835e8989","article-title":"A survey of the clinical use of SeHCAT in the UK","volume":"34","author":"Smith","year":"2013","journal-title":"Nucl Med Commun"},{"key":"2025090709093584000_9.2.92.7","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2016-000116","article-title":"How bad is bile acid diarrhoea: an online survey of patient-reported symptoms and outcomes","volume":"4","author":"Bannaga","year":"2017","journal-title":"BMJ Open Gastroenterol"},{"key":"2025090709093584000_9.2.92.8","unstructured":"National Institute for Health and Care Excellence (NICE). 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