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In this case-based review, we aim to discuss common clinical dilemmas encountered by clinicians managing patients with PSC and address related competencies in the 2010 Gastroenterology Curriculum.<\/jats:p>","DOI":"10.1136\/flgastro-2017-100815","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T05:05:16Z","timestamp":1505106316000},"page":"260-266","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Primary sclerosing cholangitis and the management of uncertainty and complexity"],"prefix":"10.1136","volume":"8","author":[{"given":"Katherine","family":"Arndtz","sequence":"first","affiliation":[{"name":"Centre for Liver Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK"},{"name":"Centre for Rare Diseases, Institute of Translational Medicine, Birmingham Health Partners, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon M","family":"Hirschfield","sequence":"additional","affiliation":[{"name":"Centre for Liver Research, NIHR Birmingham Biomedical Research Centre, University of Birmingham, Birmingham, UK"},{"name":"Centre for Rare Diseases, Institute of Translational Medicine, Birmingham Health Partners, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2017,7,25]]},"reference":[{"key":"2025090708354302000_8.4.260.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2009.04.009"},{"key":"2025090708354302000_8.4.260.2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1159\/000444471","article-title":"The pathogenesis of autoimmune liver disease","volume":"34","author":"Arndtz","year":"2016","journal-title":"Dig Dis"},{"key":"2025090708354302000_8.4.260.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(99)80297-9"},{"key":"2025090708354302000_8.4.260.4","unstructured":"Organ specific reports. 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