{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T13:06:01Z","timestamp":1773839161421,"version":"3.50.1"},"reference-count":38,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2017,7,3]]},"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To evaluate the diagnostic yield of investigating dyspepsia with oesophagogastroduodenoscopy (OGD) with or without mucosal biopsy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>Retrospective service evaluation study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>Two teaching hospitals: The Royal Hallamshire Hospital and Northern General Hospital, Sheffield Teaching Hospitals NHS Foundation Trust, UK.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients<\/jats:title>\n                  <jats:p>500 patients, 55 years of age and over, who underwent OGD to investigate dyspepsia were included. The study period included a 3-month window. All OGDs were performed on an outpatient basis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interventions<\/jats:title>\n                  <jats:p>Data were extracted from electronic OGD records within the study period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main outcome measures<\/jats:title>\n                  <jats:p>Diagnostic yield provided by endoscopic examination and histological assessment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>378 patients (75.6%) were reported to have some form of endoscopic abnormality, and 417 patients (83.4%) had biopsies taken. The most common findings at OGD were gastritis (47.2%) and oesophagitis (24.4%). Oesophagogastric malignancy was seen in 1%. Diagnoses made endoscopically or histologically that would not have been appropriately managed by empirical therapies were seen in 16.2%.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>OGD in dyspepsia influences patient management in approximately one-sixth of cases. However, the majority of patients are sufficiently managed with <jats:italic>Helicobacter pylori<\/jats:italic> testing and eradication and\/or a trial of proton pump inhibitor therapy. Further non-invasive approaches are needed to identify patients who need endoscopy for biopsy or therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/flgastro-2017-100838","type":"journal-article","created":{"date-parts":[[2017,8,5]],"date-time":"2017-08-05T20:20:18Z","timestamp":1501964418000},"page":"62-66","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Reassessing the value of gastroscopy for the investigation of dyspepsia"],"prefix":"10.1136","volume":"9","author":[{"given":"Hey-Long","family":"Ching","sequence":"first","affiliation":[{"name":"Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa F","family":"Hale","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reena","family":"Sidhu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E","family":"McAlindon","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals, Sheffield, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,8,5]]},"reference":[{"key":"2025090709444729000_9.1.62.1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"key":"2025090709444729000_9.1.62.2","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1111\/j.1572-0241.2001.03508.x","article-title":"Patients\u2019 attitudes and apprehensions about endoscopy: how to calm troubled waters","volume":"96","author":"Brandt","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"2025090709444729000_9.1.62.3","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199902000-00023"},{"key":"2025090709444729000_9.1.62.4","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1055\/s-2004-814117","article-title":"Preparation, premedication, and surveillance","volume":"36","author":"Bell","year":"2004","journal-title":"Endoscopy"},{"key":"2025090709444729000_9.1.62.5","unstructured":"Gastro-oesophageal reflux disease and dyspepsia in adults: investigation and management. 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