{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T04:59:04Z","timestamp":1764997144875,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2017,7,25]]},"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Flexible sigmoidoscopy reduces the incidence of colonic cancer through the detection and removal of premalignant adenomas. However, the efficacy of the procedure is variable. The aim of the present study was to examine factors associated with the efficacy of detecting polyps during flexible sigmoidoscopy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and patients<\/jats:title>\n                  <jats:p>Retrospective observational cohort study of all individuals undergoing routine flexible sigmoidoscopy in NHS Greater Glasgow and Clyde from January 2013 to January 2016.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 7713 patients were included. Median age was 52 years and 50% were male. Polyps were detected in 1172 (13%) patients. On multivariate analysis, increasing age (OR 1.020 (1.016\u20131.023)\u2009p&lt;0.001), male sex (OR 1.23 (1.10\u20131.38)\u2009p&lt;0.001) and the use of any bowel preparation (OR 3.55 (1.47\u20138.57)\u2009p&lt;0.001) were associated with increasing numbers of polyps being detected. There was no significant difference in the number of polyps found in patients who had received an oral laxative preparation compared with an enema (OR 3.81 (1.57\u20139.22) vs 3.45 (1.43\u20138.34)), or in those who received sedation versus those who had not (OR 1.00 vs 1.04 (0.91\u20131.17) p=0.591). Furthermore, the highest number of polyps was found when the sigmoidoscope was inserted to the descending colon (OR 1.30 (1.04\u20131.63)).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Increasing age, male sex and the utilisation of any bowel preparation were associated with an increased polyp detection rate. However, the use of sedation or oral laxative preparation appears to confer no additional benefit. In addition, the results indicate that insertion to the descending colon optimises the efficacy of flexible sigmoidoscopy polyp detection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/flgastro-2017-100849","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T20:10:18Z","timestamp":1503778218000},"page":"135-142","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Factors associated with the efficacy of polyp detection during routine flexible sigmoidoscopy"],"prefix":"10.1136","volume":"9","author":[{"given":"Akash J","family":"Maliampurakal","sequence":"first","affiliation":[{"name":"Academic Unit of Colorectal Surgery, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald C","family":"McMillan","sequence":"additional","affiliation":[{"name":"Academic Unit of Colorectal Surgery, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G","family":"Horgan","sequence":"additional","affiliation":[{"name":"Academic Unit of Colorectal Surgery, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Academic Unit of Colorectal Surgery, School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2017,8,26]]},"reference":[{"key":"2025090709171906000_9.2.135.1","unstructured":"Office for National Statistics. Colorectal Cancer [Internet]. 2012. http:\/\/www.ons.gov.uk\/ons\/rel\/cancer-unit\/bowel-cancer-in-england\/2009\/sum-colorectal.html"},{"key":"2025090709171906000_9.2.135.2","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2407-9-227","article-title":"Factors associated with improved survival among older colorectal cancer patients in the US: a population-based analysis","volume":"9","author":"Lang","year":"2009","journal-title":"BMC Cancer"},{"key":"2025090709171906000_9.2.135.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011303432203"},{"key":"2025090709171906000_9.2.135.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01875.x"},{"key":"2025090709171906000_9.2.135.5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h1662"},{"key":"2025090709171906000_9.2.135.6","doi-asserted-by":"crossref","first-page":"18466","DOI":"10.3748\/wjg.v20.i48.18466","article-title":"Reduced incidence and mortality from colorectal cancer with flexible-sigmoidoscopy screening: a meta-analysis","volume":"20","author":"Shroff","year":"2014","journal-title":"World J Gastroenterol"},{"key":"2025090709171906000_9.2.135.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60551-X"},{"key":"2025090709171906000_9.2.135.8","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djr284"},{"key":"2025090709171906000_9.2.135.9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.b1846"},{"key":"2025090709171906000_9.2.135.10","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1114635"},{"key":"2025090709171906000_9.2.135.11","first-page":"53","article-title":"Current management of inflammatory bowel disease and colorectal cancer","volume":"4","author":"Mattar","year":"2011","journal-title":"Gastrointest Cancer Res"},{"key":"2025090709171906000_9.2.135.12","doi-asserted-by":"crossref","first-page":"v6","DOI":"10.1136\/gut.51.suppl_5.v6","article-title":"Surveillance guidelines after removal of colorectal adenomatous polyps","volume":"51 Suppl 5","author":"Atkin","year":"2002","journal-title":"Gut"},{"key":"2025090709171906000_9.2.135.13","unstructured":"Guidance on the indications for diagnostic upper GI endoscopy, flexible sigmoidoscopy and colonoscopy | Endoscopy | Clinical Guidance [Internet]. 2016. Bsg.org.uk.; http:\/\/www.bsg.org.uk\/clinical-guidance\/endoscopy\/guidance-on-the-indications-for-diagnostic-upper-gi-endoscopy-flexible-sigmoidoscopy-and-colonoscopy.html"},{"key":"2025090709171906000_9.2.135.14","unstructured":"NHS Bowel Screening Programme - Piloting of Flexible Sigmoidoscopy\u00a0[Internet]. 2016 www.gov.uk; https:\/\/www.gov.uk\/government\/uploads\/system\/uploads\/attachment_data\/file\/215205\/dh_132468.pdf"},{"key":"2025090709171906000_9.2.135.15","unstructured":"Governance Arrangements for Research Ethics Committees (GAfREC) - HealthResearch Authority. Health Research Authority. 2016. http:\/\/www.hra.nhs.uk\/resources\/research-legislation-and-governance\/governance-arrangements-for-research-ethics-committees\/"},{"key":"2025090709171906000_9.2.135.16","doi-asserted-by":"publisher","DOI":"10.1080\/00223890802634175"},{"key":"2025090709171906000_9.2.135.17","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.22.2959"},{"key":"2025090709171906000_9.2.135.18","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1093\/oxfordjournals.epirev.a036154","article-title":"Epidemiology of colorectal adenomas","volume":"16","author":"Peipins","year":"1994","journal-title":"Epidemiol Rev"},{"key":"2025090709171906000_9.2.135.19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03638.x"},{"key":"2025090709171906000_9.2.135.20","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/BF02054117","article-title":"Colonoscopic bowel preparations\u2014Which one?","volume":"38","author":"Golub","year":"1995","journal-title":"Diseases of the Colon & Rectum"},{"key":"2025090709171906000_9.2.135.21","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.320.7248.1504"},{"key":"2025090709171906000_9.2.135.22","doi-asserted-by":"publisher","DOI":"10.1177\/0036933014529051"},{"key":"2025090709171906000_9.2.135.23","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-010-0993-2"},{"key":"2025090709171906000_9.2.135.24","doi-asserted-by":"publisher","DOI":"10.4321\/S1130-01082012001000002"},{"key":"2025090709171906000_9.2.135.25","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.06.001"},{"key":"2025090709171906000_9.2.135.26","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055498"}],"container-title":["Frontline Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/flgastro-2017-100849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:17:34Z","timestamp":1757261854000},"score":1,"resource":{"primary":{"URL":"https:\/\/fg.bmj.com\/lookup\/doi\/10.1136\/flgastro-2017-100849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,26]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,3,8]]},"published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1136\/flgastro-2017-100849"],"URL":"https:\/\/doi.org\/10.1136\/flgastro-2017-100849","relation":{},"ISSN":["2041-4137","2041-4145"],"issn-type":[{"type":"print","value":"2041-4137"},{"type":"electronic","value":"2041-4145"}],"subject":[],"published":{"date-parts":[[2017,8,26]]}}}