{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:34:03Z","timestamp":1757619243351,"version":"3.44.0"},"reference-count":73,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Frontline Gastroenterol"],"accepted":{"date-parts":[[2019,3,17]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:p>Ulcerative colitis (UC) is a chronic inflammatory bowel disorder with an increased risk of colorectal cancer (CRC). This has led to the implementation of surveillance programmes to minimise this risk. Overall, these proactive programmes in association with better medical therapies have reduced the incidence of CRC in this population. Specific populations remain at increased risk, such as younger age at diagnosis, primary sclerosing cholangitis, colonic strictures and pseudopolyps. The majority of gastrointestinal international societies favour chromoendoscopy with targeted biopsies or random biopsies. The aim of this review is to present the current literature on dysplasia surveillance, the methodology and endoscopic technology available to assess dysplasia in UC.<\/jats:p>","DOI":"10.1136\/flgastro-2018-101056","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T17:15:49Z","timestamp":1555089349000},"page":"124-132","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Endoscopic surveillance strategies for dysplasia in ulcerative colitis"],"prefix":"10.1136","volume":"11","author":[{"given":"Christine","family":"Verdon","sequence":"first","affiliation":[{"name":"Gastroenterology, McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achuthan","family":"Aruljothy","sequence":"additional","affiliation":[{"name":"Gastroenterology, McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter L","family":"Lakatos","sequence":"additional","affiliation":[{"name":"Gastroenterology, McGill University Health Centre, Montreal, Qu\u00e9bec, Canada"},{"name":"1st Department of Medicine, Semmelweis University, Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2610-1910","authenticated-orcid":false,"given":"Talat","family":"Bessissow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2019,4,12]]},"reference":[{"key":"2025090709404540000_11.2.124.1","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.gie.2017.07.028","article-title":"Impact of mucosal inflammation on risk of colorectal neoplasia in patients with ulcerative colitis: a systematic review and meta-analysis","volume":"86","author":"Flores","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"2025090709404540000_11.2.124.2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.526"},{"key":"2025090709404540000_11.2.124.3","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.016"},{"key":"2025090709404540000_11.2.124.4","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2012.04.054"},{"key":"2025090709404540000_11.2.124.5","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e31828029c0"},{"key":"2025090709404540000_11.2.124.6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41442.x"},{"key":"2025090709404540000_11.2.124.7","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.65"},{"key":"2025090709404540000_11.2.124.8","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14023"},{"key":"2025090709404540000_11.2.124.9","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/apt.13897","article-title":"The effects of aminosalicylates or thiopurines on the risk of colorectal cancer in inflammatory bowel disease","volume":"45","author":"Carrat","year":"2017","journal-title":"Aliment Pharmacol Ther"},{"key":"2025090709404540000_11.2.124.10","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0b013e3182802af7"},{"key":"2025090709404540000_11.2.124.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.04.185"},{"key":"2025090709404540000_11.2.124.12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.cgh.2014.06.032","article-title":"A rule for determining risk of colorectal cancer in patients with inflammatory bowel disease","volume":"13","author":"Lutgens","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025090709404540000_11.2.124.13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1403718"},{"key":"2025090709404540000_11.2.124.14","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.03.044"},{"key":"2025090709404540000_11.2.124.15","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/MEG.0000000000000576","article-title":"Increased risk of colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease: a meta-analysis of 16 observational studies","volume":"28","author":"Zheng","year":"2016","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025090709404540000_11.2.124.16","doi-asserted-by":"crossref","unstructured":"Bye WA , Nguyen TM , Parker CE , et al . Strategies for detecting colon cancer in patients with inflammatory bowel disease. The Cochrane Library 2017;13.doi:10.1002\/14651858.CD000279.pub4","DOI":"10.1002\/14651858.CD000279.pub4"},{"key":"2025090709404540000_11.2.124.17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605359"},{"key":"2025090709404540000_11.2.124.18","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90622-8"},{"key":"2025090709404540000_11.2.124.19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1046\/j.1365-2036.2000.00698.x","article-title":"Colorectal cancer prevention in ulcerative colitis: a case-control study","volume":"14","author":"Eaden","year":"2000","journal-title":"Aliment Pharmacol Ther"},{"key":"2025090709404540000_11.2.124.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2014.07.018"},{"key":"2025090709404540000_11.2.124.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.12.009"},{"key":"2025090709404540000_11.2.124.22","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/0016-5085(92)91185-7","article-title":"DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis","volume":"103","author":"Rubin","year":"1992","journal-title":"Gastroenterology"},{"key":"2025090709404540000_11.2.124.23","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.12.035"},{"key":"2025090709404540000_11.2.124.24","doi-asserted-by":"crossref","unstructured":"Singh K , Al Khoury A , Kurti A , et al . High adherence to surveillance guidelines in IBD results in low CRC and dysplasia rates, while rates of dysplasia and cancer are low before the suggested start of surveillance. Results from a tertiary IBD center. J Crohns Colitis 2019:jjz066.","DOI":"10.1093\/ecco-jcc\/jjz066"},{"key":"2025090709404540000_11.2.124.25","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2011.93"},{"key":"2025090709404540000_11.2.124.26","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1053\/j.gastro.2016.08.002","article-title":"Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer","volume":"151","author":"Watanabe","year":"2016","journal-title":"Gastroenterology"},{"key":"2025090709404540000_11.2.124.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2015.12.047"},{"key":"2025090709404540000_11.2.124.28","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-311892"},{"key":"2025090709404540000_11.2.124.29","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.04.050"},{"key":"2025090709404540000_11.2.124.30","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.23002"},{"key":"2025090709404540000_11.2.124.31","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa055498"},{"key":"2025090709404540000_11.2.124.32","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2003.50146"},{"key":"2025090709404540000_11.2.124.33","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.016386"},{"key":"2025090709404540000_11.2.124.34","doi-asserted-by":"crossref","first-page":"2982","DOI":"10.1007\/s10620-017-4772-y","article-title":"Chromoendoscopy, narrow-band imaging or white light endoscopy for neoplasia detection in inflammatory bowel diseases","volume":"62","author":"Har-Noy","year":"2017","journal-title":"Dig Dis Sci"},{"key":"2025090709404540000_11.2.124.35","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1016\/j.cgh.2016.11.021","article-title":"Chromoendoscopy for surveillance in ulcerative colitis and Crohn\"s disease: a systematic review of randomized trials","volume":"15","author":"Iannone","year":"2017","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025090709404540000_11.2.124.36","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2015.63"},{"key":"2025090709404540000_11.2.124.37","doi-asserted-by":"crossref","unstructured":"Mohammed N , Kant P , Abid F , et al . 446 high definition white light endoscopy (Hdwle) versus high definition with Chromoendoscopy (Hdce) in the detection of dysplasia in long standing ulcerative colitis: a randomized controlled trial. Gastrointest Endosc 2015;81.doi:10.1016\/j.gie.2015.03.1237","DOI":"10.1016\/j.gie.2015.03.1237"},{"key":"2025090709404540000_11.2.124.38","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1093\/ibd\/izy188","article-title":"Comparison of endoscopic dysplasia detection techniques in patients with ulcerative colitis: a systematic review and network meta-analysis","volume":"24","author":"Bessissow","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2025090709404540000_11.2.124.39","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1093\/ibd\/izy043","article-title":"Chromoendoscopy for dysplasia surveillance in inflammatory bowel disease","volume":"24","author":"Flynn","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"2025090709404540000_11.2.124.40","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(03)02159-X"},{"key":"2025090709404540000_11.2.124.41","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5107(96)70222-5"},{"key":"2025090709404540000_11.2.124.42","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/j.gie.2017.09.030","article-title":"Endoscopy in IBD: advances in dysplasia detection and management","volume":"86","author":"Kaltenbach","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"2025090709404540000_11.2.124.43","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313213"},{"key":"2025090709404540000_11.2.124.44","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/ajg.2017.417","article-title":"A randomized trial comparing high definition colonoscopy alone with high definition dye spraying and electronic virtual chromoendoscopy for detection of colonic neoplastic lesions during IBD surveillance colonoscopy","volume":"113","author":"Iacucci","year":"2018","journal-title":"Am J Gastroenterol"},{"key":"2025090709404540000_11.2.124.45","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2007.144097"},{"key":"2025090709404540000_11.2.124.46","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S2468-1253(18)30055-4","article-title":"Chromoendoscopy versus autofluorescence imaging for neoplasia detection in patients with longstanding ulcerative colitis (FIND-UC): an international, multicentre, randomised controlled trial","volume":"3","author":"Vleugels","year":"2018","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"2025090709404540000_11.2.124.47","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.giec.2013.03.008","article-title":"Surveillance in inflammatory bowel disease: chromoendoscopy and digital mucosal enhancement","volume":"23","author":"Naymagon","year":"2013","journal-title":"Gastrointest Endosc Clin N Am"},{"key":"2025090709404540000_11.2.124.48","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjx008"},{"key":"2025090709404540000_11.2.124.49","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2014.10.030"},{"key":"2025090709404540000_11.2.124.50","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1365348"},{"key":"2025090709404540000_11.2.124.51","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2010.224154"},{"key":"2025090709404540000_11.2.124.52","unstructured":"Party C , ed. Clinical practice guidelines for surveillance colonoscopy in adenoma follow-up: following curative resection of colorectal cancer; and for cancer surveillance in inflammatory bowel disease . Sydney, Australia: Cancer Council of Australia, 2011."},{"key":"2025090709404540000_11.2.124.53","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2009.727"},{"key":"2025090709404540000_11.2.124.54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07580.x"},{"key":"2025090709404540000_11.2.124.55","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-921032"},{"key":"2025090709404540000_11.2.124.56","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.01.048"},{"key":"2025090709404540000_11.2.124.57","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.01934.x"},{"key":"2025090709404540000_11.2.124.58","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-011-1130-y"},{"key":"2025090709404540000_11.2.124.59","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32834791b4"},{"key":"2025090709404540000_11.2.124.60","first-page":"1913","article-title":"Procedure time and the determination of polypoid abnormalities with experience: implementation of a chromoendoscopy program for surveillance colonoscopy for ulcerative colitis","volume":"19","author":"Picco","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"2025090709404540000_11.2.124.61","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1097\/MIB.0000000000000176","article-title":"Surveillance in ulcerative colitis: is chromoendoscopy-guided endomicroscopy always better than conventional colonoscopy? A randomized trial","volume":"20","author":"Freire","year":"2014","journal-title":"Inflamm Bowel Dis"},{"key":"2025090709404540000_11.2.124.62","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312332"},{"key":"2025090709404540000_11.2.124.63","doi-asserted-by":"crossref","unstructured":"Iacucci M , Gasia MF , Akinola O , et al . 624 final results of a randomized study comparing high definition colonoscopy alone with high definition dye spraying and electronic virtual Chromoendoscopy using iSCAN for detection of colonic neoplastic lesions during IBD surveillance colonoscopy. Gastroenterology 2016;150.doi:10.1016\/S0016-5085(16)30538-8","DOI":"10.1016\/S0016-5085(16)30538-8"},{"key":"2025090709404540000_11.2.124.64","doi-asserted-by":"crossref","unstructured":"Park SJ , Kim H-S , Yang D-H , et al . Tu2086 high definition Chromoendoscopy with water-jet versus high definition white light endoscopy in the detection of dysplasia in long standing ulcerative colitis: a multicenter prospective randomized controlled study. Gastroenterology 2016;150.doi:10.1016\/S0016-5085(16)34290-1","DOI":"10.1016\/S0016-5085(16)34290-1"},{"key":"2025090709404540000_11.2.124.65","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-966214"},{"key":"2025090709404540000_11.2.124.66","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255956"},{"key":"2025090709404540000_11.2.124.67","doi-asserted-by":"publisher","DOI":"10.1016\/j.gie.2011.05.013"},{"key":"2025090709404540000_11.2.124.68","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1097\/00054725-201112002-00045","article-title":"Narrow-band imaging and chromoendoscopy for the detecion of colonic dysplasia in inflammatory bowel disease: a prospective and randomized study","volume":"17","author":"Feitosa","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"2025090709404540000_11.2.124.69","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2012.67"},{"key":"2025090709404540000_11.2.124.70","doi-asserted-by":"crossref","first-page":"AB148","DOI":"10.1016\/j.gie.2012.04.082","article-title":"506 Chromo-Endoscopy versus narrow band imaging in ulcerative colitis: a prospective randomized controlled trial","volume":"75","author":"Bisschops","year":"2012","journal-title":"Gastrointest Endosc"},{"key":"2025090709404540000_11.2.124.71","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1097\/MIB.0b013e31829637b9","article-title":"Chromoendoscopy versus narrow band imaging for colonic surveillance in inflammatory bowel disease","volume":"19","author":"Efthymiou","year":"2013","journal-title":"Inflamm Bowel Dis"},{"key":"2025090709404540000_11.2.124.72","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1016\/j.cgh.2015.04.172","article-title":"White-Light or narrow-band imaging colonoscopy in surveillance of ulcerative colitis: a prospective multicenter study","volume":"13","author":"Leifeld","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"2025090709404540000_11.2.124.73","doi-asserted-by":"crossref","unstructured":"Watanabe K , Nishishita M , Shimamoto F , et al . 722 comparison between Newly-Developed narrow band imaging and Panchromoendoscopy for surveillance colonoscopy in patients with longstanding ulcerative colitis: a prospective multicenter randomized controlled trial, navigator study. Gastrointest Endosc 2016;83.doi:10.1016\/j.gie.2016.03.147","DOI":"10.1016\/j.gie.2016.03.147"}],"container-title":["Frontline Gastroenterology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/flgastro-2018-101056","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,7]],"date-time":"2025-09-07T16:40:55Z","timestamp":1757263255000},"score":1,"resource":{"primary":{"URL":"https:\/\/fg.bmj.com\/lookup\/doi\/10.1136\/flgastro-2018-101056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,12]]},"references-count":73,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,10]]},"published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1136\/flgastro-2018-101056"],"URL":"https:\/\/doi.org\/10.1136\/flgastro-2018-101056","relation":{},"ISSN":["2041-4137","2041-4145"],"issn-type":[{"type":"print","value":"2041-4137"},{"type":"electronic","value":"2041-4145"}],"subject":[],"published":{"date-parts":[[2019,4,12]]}}}